RESUMO
We describe a family who presented with several scattered, vascular, cutaneous lesions and was found to have a novel mutation in RASA1, diagnostic of capillary malformation-arteriovenous malformation syndrome. Our patient was initially given a presumptive clinical diagnosis of hereditary hemorrhagic telangiectasia. Capillary malformation-arteriovenous malformation syndrome shares several features with hereditary hemorrhagic telangiectasia and hereditary benign telangiectasia, but it can be distinguished clinically according to its morphologic appearance and distribution of cutaneous vascular lesions, the presence of internal fast-flow lesions, and genetic analysis.
Assuntos
Malformações Arteriovenosas/genética , Capilares/anormalidades , Mancha Vinho do Porto/genética , Proteína p120 Ativadora de GTPase/genética , Malformações Arteriovenosas/diagnóstico , Criança , Dermoscopia , Diagnóstico Diferencial , Humanos , Masculino , Mutação , Mancha Vinho do Porto/diagnóstico , Telangiectasia Hemorrágica Hereditária/diagnósticoRESUMO
We report a case of a 46-year-old female who presented with a persistent lesion on the inferior right breast. The lesion was located within the scar from a breast augmentation procedure 12 years ago. The lesion had been treated as several conditions with no improvement. Biopsy revealed a superficial and nodular basal cell carcinoma, and the lesion was successfully removed with Mohs micrographic surgery. Basal cell carcinoma arising in a surgical scar is exceedingly rare with only 13 reported cases to date. This is the first reported case of basal cell carcinoma arising in a breast augmentation scar. We emphasize the importance of biopsy for suspicious lesions or those refractory to treatment, particularly those lesions that form within a scar. Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Assuntos
Carcinoma Basocelular/diagnóstico , Cicatriz/complicações , Diagnóstico Tardio/efeitos adversos , Mamoplastia/efeitos adversos , Neoplasias Cutâneas/diagnóstico , Carcinoma Basocelular/etiologia , Carcinoma Basocelular/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Cirurgia de Mohs , Neoplasias Cutâneas/etiologia , Neoplasias Cutâneas/cirurgia , Banho de Sol/lesões , Raios Ultravioleta/efeitos adversosRESUMO
A 67-year-old woman presented with a firm plaque in the perineal region, 16 months after diagnosis of a high-grade basaloid squamous cell carcinoma of the vagina and treatment by external beam radiation therapy and vaginal cuff brachytherapy. The differential diagnosis included radiation-induced morphea, radiation dermatitis, or, possibly, radiation-induced lichen sclerosus. Biopsy findings, including special staining, confirmed the diagnosis of radiation-induced lichen sclerosus. To our knowledge, this is the first report of radiation-induced lichen sclerosus of the vulvar region.