Detalhe da pesquisa
1.
Brothers in arms: proBDNF/BDNF and sAPPα/Aß-signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of Alzheimer's disease.
Biol Chem
; 403(1): 43-71, 2022 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34619027
2.
The role of mycotoxins in neurodegenerative diseases: current state of the art and future perspectives of research.
Biol Chem
; 403(1): 3-26, 2022 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34449171
3.
The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif.
Cell Mol Life Sci
; 77(24): 5223-5242, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-32065241
4.
Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways.
J Neurochem
; 151(5): 626-641, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31063592
5.
Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.
Cell Mol Life Sci
; 75(2): 301-322, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28799085
6.
APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.
J Neurosci
; 37(21): 5345-5365, 2017 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28450540
7.
Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain.
J Neurosci
; 34(33): 11159-72, 2014 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25122912
8.
Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice.
J Neurosci
; 33(39): 15596-602, 2013 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24068826
9.
APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms.
Cell Mol Life Sci
; 69(8): 1353-75, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22105709
10.
Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function.
Mol Cell Neurosci
; 49(4): 448-55, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22353605
11.
Amyloid precursor protein (APP) regulates synaptic structure and function.
Mol Cell Neurosci
; 51(1-2): 43-52, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22884903
12.
APP family member dimeric complexes are formed predominantly in synaptic compartments.
Cell Biosci
; 13(1): 141, 2023 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37533067
13.
Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.
Acta Neuropathol Commun
; 11(1): 87, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37259128
14.
Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid ß peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid ß precursor protein (APP) juxtamembrane region.
J Biol Chem
; 286(46): 39804-12, 2011 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21868378
15.
Structural aspects and physiological consequences of APP/APLP trans-dimerization.
Exp Brain Res
; 217(3-4): 389-95, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21952790
16.
The Hidden Role of Non-Canonical Amyloid ß Isoforms in Alzheimer's Disease.
Cells
; 11(21)2022 10 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36359817
17.
Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production.
J Biol Chem
; 284(42): 28943-52, 2009 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19596858
18.
Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.
Mol Neurobiol
; 55(7): 5809-5829, 2018 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-29079999
19.
LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State.
Front Mol Neurosci
; 10: 118, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28496400
20.
Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction.
Front Mol Neurosci
; 10: 140, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28553201