Detalhe da pesquisa
1.
Advances in computational methods along the exposure to toxicological response paradigm.
Toxicol Appl Pharmacol
; 450: 116141, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35777528
2.
Thresholds Derived From Common Measures in Rat Studies Are Predictive of Liver Tumorigenic Chemicals.
Toxicol Pathol
; 48(7): 857-874, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33084515
3.
Identification of differentially expressed genes and networks related to hepatic lipid dysfunction.
Toxicol Appl Pharmacol
; 382: 114757, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31520653
4.
Application of Biologically Based Lumping To Investigate the Toxicokinetic Interactions of a Complex Gasoline Mixture.
Environ Sci Technol
; 50(6): 3231-8, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26889718
5.
Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk.
Crit Rev Toxicol
; 44(7): 600-17, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25068490
6.
Use of novel inhalation kinetic studies to refine physiologically-based pharmacokinetic models for ethanol in non-pregnant and pregnant rats.
Inhal Toxicol
; 26(10): 598-619, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25144475
7.
Cross species extrapolation of the disruption of thyroid hormone synthesis by oxyfluorfen using in vitro data, physiologically based pharmacokinetic (PBPK), and thyroid hormone kinetics models.
Curr Res Toxicol
; 5: 100138, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38074188
8.
Fate of arsenicals in mice carrying the human AS3MT gene exposed to environmentally relevant levels of arsenite in drinking water.
Sci Rep
; 13(1): 3660, 2023 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36871058
9.
Computational estimation of errors generated by lumping of physiologically-based pharmacokinetic (PBPK) interaction models of inhaled complex chemical mixtures.
Inhal Toxicol
; 24(1): 36-46, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22149415
10.
Development of multi-route physiologically-based pharmacokinetic models for ethanol in the adult, pregnant, and neonatal rat.
Inhal Toxicol
; 24(11): 698-722, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22954395
11.
A biologically based model to quantitatively assess the role of the nuclear receptors liver X (LXR), and pregnane X (PXR) on chemically induced hepatic steatosis.
Toxicol Lett
; 359: 46-54, 2022 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35143881
12.
Mechanistic Computational Model for Extrapolating In Vitro Thyroid Peroxidase (TPO) Inhibition Data to Predict Serum Thyroid Hormone Levels in Rats.
Toxicol Sci
; 183(1): 36-48, 2021 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34117770
13.
Development of a quantitative model of pregnane X receptor (PXR) mediated xenobiotic metabolizing enzyme induction.
Bull Math Biol
; 72(7): 1799-819, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20151218
14.
Arsenic Metabolism in Mice Carrying a BORCS7/AS3MT Locus Humanized by Syntenic Replacement.
Environ Health Perspect
; 128(8): 87003, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32779937
15.
Gene Expression Thresholds Derived From Short-term Exposures Identify Rat Liver Tumorigens.
Toxicol Sci
; 177(1): 41-59, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32603419
16.
Extrapolating In Vitro Screening Assay Data for Thyroperoxidase Inhibition to Predict Serum Thyroid Hormones in the Rat.
Toxicol Sci
; 173(2): 280-292, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31697382
17.
Development of an inhalation physiologically based pharmacokinetic (PBPK) model for 2,2, 4-trimethylpentane (TMP) in male Long-Evans rats using gas uptake experiments.
Inhal Toxicol
; 21(14): 1176-85, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19922404
18.
Advancing internal exposure and physiologically-based toxicokinetic modeling for 21st-century risk assessments.
J Expo Sci Environ Epidemiol
; 29(1): 11-20, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30116055
19.
How can biologically-based modeling of arsenic kinetics and dynamics inform the risk assessment process? - A workshop review.
Toxicol Appl Pharmacol
; 232(3): 359-68, 2008 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18687352
20.
Development of a human physiologically based pharmacokinetic (PBPK) model for inorganic arsenic and its mono- and di-methylated metabolites.
J Pharmacokinet Pharmacodyn
; 35(1): 31-68, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17943421