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1.
Vet Radiol Ultrasound ; 59(6): 697-704, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30159973

RESUMO

Solar foot penetration is one of the causes of deep digital flexor tendon injuries in horses, however, limited information is available on the prognosis for return to soundness in the absence of synovial sepsis. Objectives of this retrospective observational study were to describe low-field magnetic resonance imaging (MRI) findings and long-term outcome for a group of horses with this combination of clinical problems. Horses were included if low-field standing MRI of the foot was performed following puncture wounds, injury of the deep digital flexor tendon was diagnosed, and sepsis was confirmed to be absent in all adjacent synovial structures (distal interphalangeal joint, navicular bursa, and digital flexor tendon sheath). Medical records were reviewed and MRI studies were re-interpreted. Follow-up information was obtained via a telephone questionnaire at a minimum of 6 months post-injury. A total of 11 horses met inclusion criteria. In three horses, the deep digital flexor tendon injury was only visible in the T2 fast spin echo sequence and contrast radiography improved diagnostic certainty. The most commonly affected area was between the distal border of the distal sesamoid bone and the facies flexoria of the distal phalanx (6/11, 55%). Six horses (60%) had an excellent outcome (5, show jumping; 1, general purpose) and returned to full athletic function. Five horses (40%) were sound but had not yet resumed full work at the time of follow-up. Findings indicated that the prognosis for return to soundness can be good for horses with solar penetration, deep digital flexor injury, and absence of synovial sepsis.


Assuntos
Doenças do Pé/veterinária , Doenças dos Cavalos/diagnóstico por imagem , Coxeadura Animal/etiologia , Imageamento por Ressonância Magnética/veterinária , Traumatismos dos Tendões/patologia , Animais , Feminino , Doenças do Pé/diagnóstico por imagem , Doenças do Pé/patologia , Doenças dos Cavalos/etiologia , Cavalos , Coxeadura Animal/diagnóstico por imagem , Masculino , Estudos Retrospectivos , Membrana Sinovial/diagnóstico por imagem , Membrana Sinovial/patologia , Traumatismos dos Tendões/diagnóstico por imagem
2.
Vet Surg ; 45(3): 374-9, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27012927

RESUMO

OBJECTIVE: To compare a knotless, barbed suture to standard suture using laparoscopic suturing methods in an ex vivo model of equine bladder repair. STUDY DESIGN: Cadaveric study. SAMPLE POPULATION: Equine cadaver bladders (n=42). METHODS: A 5-cm incision was created and repaired in a laparoscopic training box with 4 different suture materials. Groups 1 and 2 used 2-0 poliglecaprone and 2-0 glycomer knotless, barbed suture, respectively, placed using laparoscopic instruments. Groups 3 and 4 used 0 and 2-0 polyglyconate knotless, barbed suture, respectively, placed using an automated laparoscopic suturing device. All groups used a double-layer inverting pattern. Time for suture placement was recorded. Bladders were inflated with water and bursting strength pressures recorded, including a control group of intact bladders. Statistical analysis using a linear model and taking into account the unequal variances was followed by a post-hoc Tukey's test. Significance was set at P<.05. RESULTS: Bursting strength did not vary significantly between treatment groups, but was significantly decreased compared to the control group (P<.001). Time to place the sutures with the 2 automated suture device groups (groups 3 and 4) was significantly faster than those in which the suture was placed using laparoscopic needle holders and forceps (groups 1 and 2; P=.001). CONCLUSION: Knotless, barbed suture may be a viable alternative to standard suture material for laparoscopic closure of the urinary bladder in horses. Further cyclic and in vivo testing should be performed before use in clinical cases.


Assuntos
Técnicas de Sutura/veterinária , Bexiga Urinária/cirurgia , Procedimentos Cirúrgicos Urológicos/veterinária , Animais , Fenômenos Biomecânicos , Cadáver , Cavalos , Laparoscopia/veterinária
3.
Vet Surg ; 45(8): 1066-1070, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-27684500

RESUMO

OBJECTIVE: To estimate the frequency of undetected perforations in surgical gloves during equine surgery and to identify risk factors associated with occurrence. STUDY DESIGN: Observational cohort study. SAMPLE POPULATION: Surgical gloves-292 pairs. METHODS: Water leak tests were performed on gloves after equine surgery to detect perforations. Fifty pairs of unused gloves were also tested. Potential risk factors were recorded. Logistic regression was used to explore associations between putative risk factors and perforation. RESULTS: No perforations were detected in the unused gloves. Of 292 pairs of used gloves tested, 80 (27%) had at least one glove perforation per pair. The frequency of perforations was not different between surgery diplomates and residents (P=.69). The length and type of surgery were significantly associated with the likelihood of undetected glove perforation with surgeries longer than 60 minutes approximately 2.5 times more likely to result in glove perforation (P=.005). Surgery classified as soft tissue, orthopedic or exploratory celiotomy was 3 times more likely to result in glove perforation than minimally invasive surgery. The perforations occurred significantly more frequently in the nondominant hand (19%) than the dominant hand (11%) (P=.009). CONCLUSION: There is a high occurrence of undetected glove perforation in equine surgery. Precautions can be suggested based on this study although further investigation is required to assess whether glove perforations are associated with surgical site infections.


Assuntos
Falha de Equipamento/veterinária , Luvas Cirúrgicas , Cavalos/cirurgia , Cirurgia Veterinária/instrumentação , Animais , Estudos de Coortes , Quebeque , Fatores de Risco , Cirurgia Veterinária/classificação
4.
Can Vet J ; 57(2): 164-8, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26834268

RESUMO

This prospective clinical study evaluates the effectiveness of an alcohol-based hand rub (Avagard™) for pre-surgical hand antisepsis in an equine hospital and compares it with traditional scrubbing technique using 4% chlorhexidine gluconate sponges and water. Prior to elective surgery, 3 board-certified surgeons were randomly assigned to hand antisepsis with either technique. Culture samples of each hand were taken at 4 times: before and after neutral soap hand wash, after scrub or rubbing technique, and after surgery. There was no significant difference in mean bacterial colony forming units between scrub and rub techniques over the 3 time periods (P = 0.6), controlling for initial counts. One horse from the scrub group had a skin incision infection following stifle arthroscopy; this was resolved with medical treatment. The alcohol-based hand rub is equivalent in efficacy for pre-surgical hand antisepsis to traditional water-based scrubs in an equine hospital setting.


Comparaison de l'alcool à friction et d'une technique de brossage au gluconate de chlorhexidine à base d'eau pour l'antisepsie des mains avant les chirurgies non urgentes chez les chevaux. Cette étude clinique prospective évalue l'efficacité d'un alcool à friction (AvagardMD) pour l'antisepsie des mains préalable à une chirurgie dans un hôpital équin et elle la compare à la technique de brossage traditionnelle au moyen d'éponges de gluconate de chlorhexidine 4 % et d'eau. Avant une chirurgie non urgente, trois chirurgiens agréés ont été assignés au hasard à l'antisepsie des mains avec l'une ou l'autre technique. Des échantillons de chaque main ont été prélevés quatre fois pour culture : avant et après le lavage des mains avec un savon neutre, après la technique de brossage et de friction et après la chirurgie. Il n'y avait aucune différence significative dans les moyennes des dénombrements bactériens d'unités formatrices de colonies entre les techniques de brossage et de friction pendant les trois périodes de temps (P = 0,6), en tenant compte des témoins pour les dénombrements initiaux. Un cheval du groupe de brossage a développé une infection au site de l'incision après une arthroscopie du grasset qui a été résolue par traitement médical. La friction des mains à l'alcool est équivalente, en matière d'efficacité pour l'antisepsie des mains avant la chirurgie, au brossage traditionnel à l'eau dans un milieu hospitalier équin.(Traduit par Isabelle Vallières).


Assuntos
Antissepsia/métodos , Bactérias/efeitos dos fármacos , Clorexidina/análogos & derivados , Etanol/farmacologia , Desinfecção das Mãos , Mãos/microbiologia , Doenças dos Cavalos/microbiologia , Infecção da Ferida Cirúrgica/veterinária , Animais , Bactérias/isolamento & purificação , Clorexidina/farmacologia , Contagem de Colônia Microbiana , Doenças dos Cavalos/prevenção & controle , Cavalos , Humanos , Período Pré-Operatório , Infecção da Ferida Cirúrgica/prevenção & controle
5.
Vet Surg ; 43(4): 430-6, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24708523

RESUMO

OBJECTIVE: To (1) compare strain on the dorsal aspect of the proximal phalanx (P1) between 2 types of transfixation pin casts (TPC) and (2) evaluate the change in strain as the pins are removed. STUDY DESIGN: Experimental. ANIMALS: Equine cadaver forelimbs (n = 10 pair). METHODS: Each limb of a pair was assigned to 1 of 2 TPC constructs. Construct 1 consisted of a TPC with 2 positive profile, centrally threaded pins placed in the distal aspect of the third metacarpus (MC3) and construct 2 had 4 smooth Steinmann pins placed similarly. A strain gauge was mounted on P1 and axial compression (444.8-5337.9 N) applied. One forelimb of each pair was tested as a control with no construct in place. The 2 TPC groups were retested after removal of 1 proximal (n = 5 limbs) or distal (n = 5) pin from construct 1, and 2 proximal (n = 5) or distal (n = 5) pins from construct 2. Limb specimens were retested after all pins had been removed. RESULTS: There was a significant decrease in strain between both TPC constructs and the non-casted control at all loads except 444.8 N. There was no significant difference in strain reduction between the 2 TPC constructs. After proximal pin removal there was a 7% (construct 1) and 10% (construct 2) increase in strain. When distal pins were removed there was a 0.5% (construct 1) and 1% (construct 2) increase in strain. The difference between proximal and distal pin removal was only statistically different from each other at high loads. CONCLUSION: Both constructs provided equivalent reduction in strain. Removal of the proximal pin(s) increased the strain.


Assuntos
Pinos Ortopédicos/veterinária , Moldes Cirúrgicos/veterinária , Cavalos , Animais , Fenômenos Biomecânicos , Cadáver
6.
Vet Clin North Am Small Anim Pract ; 51(5): 1099-1109, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34238600

RESUMO

This article provides a summary of the current veterinary and medical literature concerning mentor-mentee relationships. In particular, the authors discuss how mentorship may be expanded and improved to address current challenges faced by the veterinary profession. They consider both the positive effects of mentorship on retention and recruitment, mental well-being, and competency, as well as the potential negatives or downsides of mentorship. Although rigorous, controlled studies are rare, the available evidence indicates that mentorship may be a key method to restore career satisfaction in veterinary medicine. Further studies are needed as well as monitoring programs.


Assuntos
Tutoria , Mentores , Animais , Docentes de Medicina , Humanos
7.
Equine Vet J ; 53(1): 18-29, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32463930

RESUMO

BACKGROUND: There are currently no evidence summaries on wounds in the horse. OBJECTIVES: To develop evidence-based guidelines on wound management in the horse. STUDY DESIGN: Evidence review using the GRADE framework. METHODS: Research questions were proposed by a panel of veterinarians, and developed into PICO format. Evidence in the veterinary literature was evaluated using the GRADE evidence-to-decision framework. Searches for human evidence summaries were conducted in the NICE, Cochrane and JBI databases. Final recommendations were based on both veterinary and human evidence. RESULTS AND RECOMMENDATIONS: The research questions were categorised into three areas: A. Wound lavage and topical treatments; B. Wound debridement and closure; C. Therapeutics for wound healing. Three hundred and six veterinary publications were identified across thirteen different topics. Fourteen papers were assessed using the GRADE criteria. Twenty-five human evidence summaries were reviewed. The results were developed into recommendations: Wound lavage and topical treatments: (i) Tap water should be considered instead of saline for lavage; (ii) Povidone iodine lavage should be considered for contaminated wounds; (iii) Topical silver sulfadiazine may not be suitable for acute wounds; (iv) Optimal lavage pressures are around 13 psi. Wound debridement and closure: (i) Debridement pads should be considered for wound preparation; (ii) Larvae debridement should be considered in selected cases; (iii) Hydrosurgery should be considered in acute contaminated wounds. Therapeutics for wound healing: (i) Honey may reduce duration of some phases of wound healing. There was insufficient evidence to draw conclusions on the use of chemical debridement, therapeutic ultrasound, laser therapy, wound closure with staples compared to sutures, or identify optimal concentrations of antiseptic lavage solutions. MAIN LIMITATIONS: Low quality evidence in veterinary literature; majority of recommendations were based on human evidence. CONCLUSIONS: These findings should be used to inform decision-making in equine primary care practice.


Assuntos
Anti-Infecciosos Locais , Doenças dos Cavalos , Animais , Antibacterianos/uso terapêutico , Doenças dos Cavalos/tratamento farmacológico , Cavalos , Atenção Primária à Saúde , Infecção da Ferida Cirúrgica/tratamento farmacológico , Infecção da Ferida Cirúrgica/veterinária , Cicatrização
8.
Vet Surg ; 39(5): 594-600, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20459495

RESUMO

OBJECTIVE: To compare the mechanical properties and failure modes of a standardized short oblique distal radial metaphyseal osteotomy stabilized using either a transfixation pin cast (TPC), a modular-sidebar external skeletal fixator (ESF), or a solid-sidebar ESF (modular- or solid-ESF, respectively) using static or cyclic axial loading to failure. STUDY DESIGN: In vitro study. ANIMALS: Equine cadaver forelimbs. METHODS: A 30 degrees oblique distal radial osteotomy was created and stabilized using 1 of the 3 fixation methods: (1) TPC, (2) modular-ESF, or (3) solid-ESF. Limbs were tested using static (TPC, modular-ESF, and solid-ESF) or cyclic (TPC and solid-ESF) axial loading to failure. The stiffness, yield load, yield displacement, failure load, and failure displacement for static loading and the cycles to failure for cyclic loading at 75% failure load were obtained. Data were analyzed using a Kruskal-Wallis test. Level of significance was P<.05. RESULTS: The solid-ESF had a greater stiffness, higher yield and failure load and a lower yield and failure displacement than the TPC (P=.01) and the modular-ESF (P=.02). TPC had a higher yield load, failure load, and yield displacement than the modular-ESF (P=.01). Mean cycles to failure for TPC was 2996+/-657 at a load of 16,000 N and for solid-ESF 6560+/-90 cycles at a load of 25,000 N. CONCLUSIONS: The solid-ESF was stiffer and stronger than the TPC and modular-ESF and failed at a greater number of cycles in axial loading compared with the TPC. CLINICAL RELEVANCE: This study is an initial step in evaluating the solid-ESF. Further testing needs to be performed, but this fixation may offer a viable alternative to the traditional TPC for stabilization of long bone fractures in adult horses.


Assuntos
Fixadores Externos/veterinária , Cavalos/cirurgia , Osteotomia/veterinária , Rádio (Anatomia)/cirurgia , Animais , Fenômenos Biomecânicos , Técnicas In Vitro , Osteotomia/métodos , Fraturas do Rádio/cirurgia , Fraturas do Rádio/veterinária , Suporte de Carga
9.
Vet Comp Orthop Traumatol ; 33(1): 15-21, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31499541

RESUMO

OBJECTIVES: The aim of this study was to determine whether a clamped drill guide can be used effectively to drill across equine distal third metacarpals and metatarsals and to compare accuracy and speed of a drilling with a hand-held drill guide. STUDY DESIGN: Eighty equine cadaver limbs were divided between four surgeons with varying experience. The limbs were randomly allocated to clamped or hand-held drill guides and placed in a stand in an upright/standing position on a metal table. Drilling times from cis- to trans cortices were measured. Post-drilling computed tomography images were used to assess drilling deviations in the dorsopalmar and proximodistal directions. RESULTS: Mean proximodistal deviation of the drill hole was distad for both guides and significantly (p = 0.01) less for the clamped drill guide +0.35° (range: -5.42°, +6.61°, standard deviation [SD] ± 3.18°) than the hand-held drill guide +2.05° (range: -5.24°, +9.81°, SD ± 3.69°). Mean dorsopalmar/plantar deviation was non-significantly (p = 0.17) less for the clamped drill guide -0.27° (range: -9.72°, +6.58°, SD ± 3.57°) than the hand-held drill guide +0.60° (range: -9.74°, + 12.33°, SD ± 4.51°). Mean time taken to drill from cis to trans cortex was significantly (p < 0.001) shorter with the clamped drill guide (41.2s) than the hand-held guide (56.6s). CONCLUSION: The clamped drill guide could be used successfully on the equine distal third metacarpals and metatarsals and resulted in some improved accuracy and reduced drilling time compared with the hand-held guide. The use of the clamped drill guide in vivo could be supported. This may be of benefit for certain fracture repairs in equids.


Assuntos
Cavalos/cirurgia , Ossos Metacarpais/cirurgia , Ossos do Metatarso/cirurgia , Equipamentos Cirúrgicos/veterinária , Animais , Cadáver , Procedimentos Ortopédicos/veterinária
10.
J Am Vet Med Assoc ; 233(2): 285-8, 2008 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-18627235

RESUMO

CASE DESCRIPTION: A 13-year-old female Miniature Horse was evaluated for progressive unilateral exophthalmia of the left globe of 3 weeks' duration. CLINICAL FINDINGS: Results of a physical examination were unremarkable. Ophthalmic examination identified exophthalmus of the left globe with complete resistance to retropulsion and mild blepharoconjunctivitis. Computed tomography revealed a large, space-occupying mass within the left caudal maxillary and left conchofrontal sinuses. The mass extended into the left retrobulbar space and contacted the cribriform plate. Trephination yielded copious amounts of turbid yellow fluid. The diagnosis was a sinonasal cyst. TREATMENT AND OUTCOME: Subtotal surgical excision of the cyst via a frontonasal osteoplastic flap was curative, with complete resolution of the exophthalmus. Histologic examination confirmed diagnosis of a sinonasal cyst. There was no evidence of cyst recurrence by 4 months after surgery. CLINICAL RELEVANCE: Sinonasal cyst should be a differential diagnosis for retrobulbar disease in horses. Exophthalmia may be the only clinical finding in horses with a sinonasal cyst.


Assuntos
Cistos/veterinária , Exoftalmia/veterinária , Doenças dos Cavalos/diagnóstico , Doenças dos Seios Paranasais/veterinária , Animais , Cistos/complicações , Cistos/cirurgia , Diagnóstico Diferencial , Exoftalmia/etiologia , Exoftalmia/cirurgia , Feminino , Doenças dos Cavalos/cirurgia , Cavalos , Doenças dos Seios Paranasais/complicações , Doenças dos Seios Paranasais/cirurgia , Resultado do Tratamento
11.
Vet Surg ; 37(6): 558-63, 2008 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-19134106

RESUMO

OBJECTIVE: To analyze the effect of the intraoperative use of sodium carboxymethylcellulose (CBMC) and related perioperative factors on postoperative colic and survival in horses that had abdominal surgery for colic. STUDY DESIGN: Retrospective study. ANIMALS: Horses (n=203) that had surgery for small intestinal disease; 33 horses had intraoperative administration of CBMC. METHODS: Information was obtained from medical records for 170 horses that had surgery for colic before use of CBMC and 33 horses that had intraoperative CBMC. Kaplan-Meier survival curves were used to estimate median survival time and a Cox proportional hazards model was used to estimate the hazard ratio for the effect of CBMC and other perioperative variables on survival. RESULTS: Seventy-five percent of horses administered CBMC survived to 180 days, whereas 75% of untreated horses survived 8 days (median survival time=18 days). Horses not administered CBMC were twice as likely to die compared with horses administered CBMC. Horses that had postoperative ileus (POI) were 1.4 times more likely to die than horses without ileus. Similarly, horses with signs of colic after surgery were 1.3 times more likely to die than horses without postoperative signs of colic. CONCLUSIONS: CBMC administration is seemingly protective against death and prolongs survival when used intraoperatively in horses with small intestine disease, particularly horses with postoperative colic or POI. Both POI and colic increased risk of death after surgery. CLINICAL RELEVANCE: Intraoperative administration of CBMC in horses that have surgery for small intestinal disease may improve survival, possibly by reducing early adhesion formation.


Assuntos
Carboximetilcelulose Sódica/uso terapêutico , Cólica/veterinária , Doenças dos Cavalos/mortalidade , Doenças dos Cavalos/cirurgia , Aderências Teciduais/veterinária , Animais , Cólica/prevenção & controle , Cólica/cirurgia , Feminino , Cavalos , Estimativa de Kaplan-Meier , Masculino , Complicações Pós-Operatórias/tratamento farmacológico , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/mortalidade , Complicações Pós-Operatórias/veterinária , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Fatores de Risco , Fatores de Tempo , Aderências Teciduais/prevenção & controle
12.
Am J Vet Res ; 68(1): 76-80, 2007 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17199422

RESUMO

OBJECTIVE: To assess expression of cyclooxygenase (COX)-1 and -2 in naturally occurring squamous cell carcinomas (SCCs) and the analogous normal tissues in horses. SAMPLE POPULATION: Tissue samples collected from 3 conjunctival, 2 vulvar, 4 preputial, and 5 penile SCCs during surgical excision in 14 horses and from corresponding body regions (conjunctiva [n = 5 horses], vulva [2], prepuce [3], and penis [3]) in 5 horses euthanized for reasons unrelated to neoplasia. PROCEDURES: Tissue samples were snap frozen in liquid nitrogen and stored at -80 degrees C until analysis. Protein was extracted from the frozen tissues, and western blot analyses were performed. Nonneoplastic and abnormal tissues from each body region were run on the same blot, and blots were run in triplicate. Molecular-weight markers and COX-1 and 2 ovine standards (positive control samples) were run concurrently on the gels; negative control samples were not used. RESULTS: All tissues, including the nonneoplastic and SCC tissues, expressed both COX-1 and -2 proteins. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that the expression of COX proteins in both nonneoplastic and SCC-affected tissues in horses is markedly different from that in other species. The reason for the potential benefit of COX-2 inhibitors in horses and other species is unknown. Further research needs to be performed to evaluate the efficacy of COX-2 inhibitors as cancer treatments in horses. Investigation of the mechanisms of tumor development in horses should be performed to increase understanding of this disease and ascertain how the mechanisms differ from those in other animals.


Assuntos
Carcinoma de Células Escamosas/veterinária , Ciclo-Oxigenase 1/biossíntese , Ciclo-Oxigenase 2/biossíntese , Doenças dos Cavalos/enzimologia , Neoplasias/veterinária , Animais , Western Blotting/veterinária , Carcinoma de Células Escamosas/enzimologia , Feminino , Cavalos , Masculino , Neoplasias/enzimologia
13.
J Am Vet Med Assoc ; 231(5): 755-8, 2007 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-17764439

RESUMO

CASE DESCRIPTION: A 24-year-old 732-kg (1,610-lb) pregnant Belgian draft horse mare developed neuropathy and signs of intractable pain following colic surgery. CLINICAL FINDINGS: Following recovery from colic surgery to treat compression of the small and large intestines because of a large fetus, the mare was noticed to have signs of femoral neuropathy involving the left hind limb. Within 36 hours after recovery, the mare developed signs of severe pain that were unresponsive to conventional treatment. No gastrointestinal tract or muscular abnormalities were found, and the discomfort was attributed to neuropathic pain. TREATMENT AND OUTCOME: The mare was treated with gabapentin (2.5 mg/kg [1.1 mg/lb], PO, q 12 h). Shortly after this treatment was initiated, the mare appeared comfortable and no longer had signs of pain. Treatment was continued for 6 days, during which the dosage was progressively decreased, and the mare was discharged. The mare subsequently delivered a healthy foal. CLINICAL RELEVANCE: Gabapentin appeared to be a safe, effective, and economical treatment for neuropathic pain in this horse.


Assuntos
Aminas/uso terapêutico , Analgésicos/uso terapêutico , Ácidos Cicloexanocarboxílicos/uso terapêutico , Neuralgia/veterinária , Ácido gama-Aminobutírico/uso terapêutico , Aminas/efeitos adversos , Analgésicos/efeitos adversos , Animais , Cólica/cirurgia , Cólica/veterinária , Ácidos Cicloexanocarboxílicos/efeitos adversos , Feminino , Gabapentina , Cavalos , Neuralgia/tratamento farmacológico , Neuralgia/etiologia , Medição da Dor , Complicações Pós-Operatórias/tratamento farmacológico , Complicações Pós-Operatórias/veterinária , Gravidez , Segurança , Resultado do Tratamento , Ácido gama-Aminobutírico/efeitos adversos
14.
Sci Rep ; 7(1): 8843, 2017 08 18.
Artigo em Inglês | MEDLINE | ID: mdl-28821845

RESUMO

Asthmatic airways are inflamed and undergo remodelling. Inhaled corticosteroids and long-acting ß2-agonist combinations are more effective than inhaled corticosteroid monotherapy in controlling disease exacerbations, but their effect on airway remodelling and inflammation remains ill-defined. This study evaluates the contribution of inhaled fluticasone and salmeterol, alone or combined, to the reversal of bronchial remodelling and inflammation. Severely asthmatic horses (6 horses/group) were treated with fluticasone, salmeterol, fluticasone/salmeterol, or with antigen avoidance for 12 weeks. Lung function, central and peripheral airway remodelling, and bronchoalveolar inflammation were assessed. Fluticasone/salmeterol and fluticasone monotherapy decreased peripheral airway smooth muscle remodelling after 12 weeks (p = 0.007 and p = 0.02, respectively). On average, a 30% decrease was observed with both treatments. In central airways, fluticasone/salmeterol reversed extracellular matrix remodelling after 12 weeks, both within the lamina propria (decreased thickness, p = 0.005) and within the smooth muscle layer (p = 0.004). Only fluticasone/salmeterol decreased bronchoalveolar neutrophilia (p = 0.03) to the same extent as antigen avoidance already after 8 weeks. In conclusion, this study shows that fluticasone/salmeterol combination decreases extracellular matrix remodelling in central airways and intraluminal neutrophilia. Fluticasone/salmeterol and fluticasone monotherapy equally reverse peripheral airway smooth muscle remodelling.


Assuntos
Remodelação das Vias Aéreas/efeitos dos fármacos , Asma/diagnóstico , Asma/etiologia , Fluticasona/farmacologia , Infiltração de Neutrófilos/efeitos dos fármacos , Infiltração de Neutrófilos/imunologia , Neutrófilos/efeitos dos fármacos , Neutrófilos/imunologia , Xinafoato de Salmeterol/farmacologia , Adolescente , Animais , Antígenos/imunologia , Asma/tratamento farmacológico , Broncodilatadores/farmacologia , Criança , Progressão da Doença , Matriz Extracelular/metabolismo , Feminino , Cavalos , Humanos , Masculino , Músculo Liso/efeitos dos fármacos , Músculo Liso/metabolismo , Neutrófilos/metabolismo , Índice de Gravidade de Doença , Adulto Jovem
15.
Vet Clin North Am Equine Pract ; 22(2): 419-36, ix, 2006 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-16882482

RESUMO

This article addresses the pathophysiology, diagnosis, management, and prognosis of several different infections within the equine abdomen and pelvic region. The latest advances in the diagnosis and treatment of perirectal abscesses, umbilical infections, and local and diffuse peritonitis are discussed. Emphasis is placed on recent advances in diagnostics and therapeutics with reference to human literature that may be useful in equine practice.


Assuntos
Abscesso/veterinária , Doenças dos Cavalos/terapia , Peritonite/veterinária , Doenças Retais/veterinária , Umbigo/microbiologia , Abscesso Abdominal/diagnóstico , Abscesso Abdominal/terapia , Abscesso Abdominal/veterinária , Abscesso/diagnóstico , Abscesso/terapia , Animais , Animais Recém-Nascidos , Doenças dos Cavalos/diagnóstico , Doenças dos Cavalos/etiologia , Cavalos , Humanos , Peritonite/microbiologia , Prognóstico , Doenças Retais/diagnóstico , Doenças Retais/terapia
16.
J Am Vet Med Assoc ; 243(3): 406-10, 2013 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-23865884

RESUMO

OBJECTIVE: To determine survival rate and athletic ability after nonsurgical or surgical treatment of cleft palate in horses. DESIGN: Retrospective case series. ANIMALS: 55 horses with cleft palate. PROCEDURES: 13 of the 55 horses died or were euthanized without treatment and were not included in all analyses. Medical records were reviewed for signalment, history, method of diagnosis, soft or hard palate involvement, type of surgical procedure performed, postoperative complications, and survival to hospital discharge. Information on athletic ability was acquired from race records and follow-up conversations with owners, trainers, or referring veterinarians. RESULTS: The predominant reason for initial evaluation was milk or feed in the nostrils (60%). The diagnosis was confirmed by means of videoendoscopy of the upper portion of the airway in all cases. Most cases involved the soft palate only (92.7%). Twenty-six of the 55 (47.3%) horses underwent surgical repair, and 12 of these had dehiscence at the caudal edge of the soft palate. Among potential racehorses, 14 of 33 had surgery. Of these, 12 of 14 survived to discharge and 2 horses raced. Among potential racehorses, 10 of 33 were discharged without surgery and 2 of these raced. Among nonracehorses, 12 of 22 underwent surgery and 11 survived to discharge. All horses that were discharged and for which follow-up information was available survived to 2 years of age or older without ill thrift despite dehiscence at the caudal edge of the soft palate and continued mild nasal discharge. CONCLUSIONS AND CLINICAL RELEVANCE: Horses with cleft palate had a higher survival rate than previously reported.


Assuntos
Fissura Palatina/veterinária , Doenças dos Cavalos/terapia , Animais , Fissura Palatina/terapia , Feminino , Cavalos , Masculino , Complicações Pós-Operatórias/veterinária , Procedimentos de Cirurgia Plástica/efeitos adversos , Procedimentos de Cirurgia Plástica/veterinária , Corrida , Esportes , Deiscência da Ferida Operatória/veterinária , Análise de Sobrevida
18.
Vet Surg ; 34(6): 657-61, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-16343157

RESUMO

OBJECTIVES: To report the diagnosis and outcome after surgical correction of bilateral distal ureteral anomalies in a Standardbred filly. STUDY DESIGN: Clinical case report. ANIMAL: An 8-month-old, 310 kg Standardbred filly with left ureteral atresia and right ureteral ectopia. METHODS: The filly was admitted for evaluation of incontinence since birth and severe urine scalding of the hindquarters. Diagnosis was made by both direct (cystoscopy and vaginoscopy) and indirect (intravenous pyelography, ultrasonography, and scintigraphy) evaluation of the ureters and bladder. The filly had left ureteral atresia, hydronephrosis, and decreased left-sided renal function and right ureteral ectopia before surgery. Surgical correction was performed on the left by an end-to-side stapled anastomosis technique and on the right by a side-to-side hand-sewn anastomosis technique. RESULTS: Surgical correction was successful. The filly had no postoperative complications and remained continent 18 months after surgery. Left renal function improved. CONCLUSION: Ureteral anomalies can be successfully repaired in larger (>300 kg) foals and some renal function may be restored after surgical correction. CLINICAL RELEVANCE: Scintigraphy should be considered in diagnosis of ureteral anomalies, assessing renal function, and determining prognosis for horses with hydronephrosis caused by ureteral ectopia and atresia.


Assuntos
Doenças dos Cavalos/cirurgia , Nefropatias/veterinária , Ureter/anormalidades , Ureter/cirurgia , Anormalidades Urogenitais/veterinária , Anastomose Cirúrgica/veterinária , Animais , Animais Recém-Nascidos , Feminino , Cavalos , Nefropatias/cirurgia , Testes de Função Renal , Complicações Pós-Operatórias/veterinária , Resultado do Tratamento , Anormalidades Urogenitais/cirurgia
19.
Vet Surg ; 31(3): 195-200, 2002.
Artigo em Inglês | MEDLINE | ID: mdl-11994846

RESUMO

OBJECTIVE: To report a technique for, and outcome after, arthroscopic removal of dorsoproximal chip fractures of a proximal phalanx in standing horses. STUDY DESIGN: Retrospective study. ANIMALS OR SAMPLE POPULATION: A total of 104 horses, 1 to 13 years of age, with a dorsoproximal chip fracture of a proximal phalanx. METHODS: Horses were restrained in standing stocks and sedated with intravenous xylazine, detomidine, or a combination of both drugs. Local analgesia was achieved with 2% mepivacaine administered intra-articularly and by subcutaneous infiltration in a crescent-shaped block dorsal to the fetlock. Sterile drapes were placed on the surgical field, and impervious drapes were used on the hoof and floor. Arthroscopic portals were created in the dorsal pouch of the metacarpophalangeal or metatarsophalangeal joints to remove chip fractures. Statistical analysis was performed on race records for all Thoroughbred racehorses and compared with previously published studies. Operative and hospitalization times were compared with those of the general hospital population, and risks associated with general anesthesia were examined. RESULTS: No major operative or postoperative complications occurred. Ninety-one percent of racehorses raced after surgery with 78% returning to race at the same or higher level. CONCLUSION: Standing arthroscopic surgery can be performed successfully to remove dorsoproximal chip fractures of the proximal phalanx. CLINICAL RELEVANCE: Standing arthroscopic surgery is a valid alternative treatment for experienced surgeons to avoid the expense and potential risks associated with general anesthesia.


Assuntos
Artroscopia/veterinária , Fraturas de Estresse/veterinária , Cavalos/cirurgia , Articulação Metacarpofalângica/cirurgia , Anestesia Local/métodos , Anestesia Local/veterinária , Animais , Artroscopia/métodos , Cruzamento , Feminino , Fraturas de Estresse/cirurgia , Cavalos/lesões , Cavalos/fisiologia , Masculino , Articulação Metacarpofalângica/lesões , Condicionamento Físico Animal , Postura/fisiologia , Esportes
20.
Vet Surg ; 32(2): 187-90, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-12692764

RESUMO

OBJECTIVE: To describe the surgical technique, complications, and outcome of thyroidectomy in 6 horses. STUDY DESIGN: Retrospective study. ANIMALS: Six horses, 10 to 22 years of age, with unilateral, rapidly enlarging thyroid masses. METHODS: Medical records between 1985 and 2000 were reviewed for horses that had unilateral thyroidectomy. Retrieved data included signalment, physical, clinical, and ultrasonographic examination findings, surgical technique, complications, and outcome. A minimum of 6 months follow-up was obtained. RESULTS: Six horses were identified. Three horses had tracheal compression and 2 of these also had exercise intolerance. On ultrasonography (5 horses), the enlarged thyroid ranged from 125 to 990 cm(3), and had either a heterogeneous (1 horse), cystic (2), or homogeneous (2) appearance. En bloc, unilateral thyroidectomy under general anesthesia was performed in all horses. After surgery, 3 horses had ipsilateral laryngeal hemiplegia, but tracheal compression was resolved. Thyroid masses were adenoma (3), C-cell compact carcinoma (1), and adenocarcinoma (1). No tumor recurrence or metastatic disease was reported 6 to 14 months after surgery. CONCLUSIONS: Unilateral thyroidectomy can be successfully performed in horses with large thyroid tumors, but laryngeal hemiplegia can be an important surgical complication. Ultrasonographic examination is useful to define thyroid enlargement and location but is seemingly not useful to characterize tumor type. CLINICAL RELEVANCE: Thyroidectomy is an uncommon surgical procedure and has an attendant risk for recurrent laryngeal nerve damage. Laryngoscopic examination before and after surgery and careful isolation of the recurrent laryngeal nerve during surgery is recommended.


Assuntos
Doenças dos Cavalos/epidemiologia , Doenças dos Cavalos/cirurgia , Doenças da Glândula Tireoide/veterinária , Adenocarcinoma/epidemiologia , Adenocarcinoma/cirurgia , Adenocarcinoma/veterinária , Adenoma/epidemiologia , Adenoma/cirurgia , Adenoma/veterinária , Animais , Carcinoma Medular/epidemiologia , Carcinoma Medular/cirurgia , Carcinoma Medular/veterinária , Cistos/epidemiologia , Cistos/cirurgia , Cistos/veterinária , Feminino , Doenças dos Cavalos/diagnóstico por imagem , Doenças dos Cavalos/patologia , Cavalos , Masculino , Pennsylvania/epidemiologia , Complicações Pós-Operatórias/veterinária , Registros/veterinária , Estudos Retrospectivos , Doenças da Glândula Tireoide/epidemiologia , Doenças da Glândula Tireoide/cirurgia , Neoplasias da Glândula Tireoide/epidemiologia , Neoplasias da Glândula Tireoide/cirurgia , Neoplasias da Glândula Tireoide/veterinária , Tireoidectomia/estatística & dados numéricos , Tireoidectomia/veterinária , Ultrassonografia
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