Learning the rules of the game: The role of generic "you" and "we" in shaping children's interpretations of norms.

A critical skill of childhood is learning social norms. We examine whether the generic pronouns "you" and "we," which frame information as applying to people in general rather than to a specific individual, facilitate this process. In one pre-registered experiment conducted online between 2020 and 2021, children 4- to 9-year-old primarily living in the midwestern U.S. (N = 146, 75 girls, 71 boys, Mage  = 7.14, SD = 1.69, 82% White) interpreted actions described with generic pronouns (vs. "I") as normatively correct and selected the speaker who used generic pronouns as the rule-follower, particularly when generic pronouns were presented first. There were no significant effects of age. These results illustrate how generic pronouns influence how children discern unfamiliar norms and form interpersonal judgments.

Knowledge of animal appearance among sighted and blind adults.

How does first-person sensory experience contribute to knowledge? Contrary to the suppositions of early empiricist philosophers, people who are born blind know about phenomena that cannot be perceived directly, such as color and light. Exactly what is learned and how remains an open question. We compared knowledge of animal appearance across congenitally blind (n = 20) and sighted individuals (two groups, n = 20 and n = 35) using a battery of tasks, including ordering (size and height), sorting (shape, skin texture, and color), odd-one-out (shape), and feature choice (texture). On all tested dimensions apart from color, sighted and blind individuals showed substantial albeit imperfect agreement, suggesting that linguistic communication and visual perception convey partially redundant appearance information. To test the hypothesis that blind individuals learn about appearance primarily by remembering sighted people's descriptions of what they see (e.g., "elephants are gray"), we measured verbalizability of animal shape, texture, and color in the sighted. Contrary to the learn-from-description hypothesis, blind and sighted groups disagreed most about the appearance dimension that was easiest for sighted people to verbalize: color. Analysis of disagreement patterns across all tasks suggest that blind individuals infer physical features from non-appearance properties of animals such as folk taxonomy and habitat (e.g., bats are textured like mammals but shaped like birds). These findings suggest that in the absence of sensory access, structured appearance knowledge is acquired through inference from ontological kind.

Field-Effect Transistor-Based Biosensors for Environmental and Agricultural Monitoring.

The precise monitoring of environmental contaminants and agricultural plant stress factors, respectively responsible for damages to our ecosystems and crop losses, has nowadays become a topic of uttermost importance. This is also highlighted by the recent introduction of the so-called "Sustainable Development Goals" of the United Nations, which aim at reducing pollutants while implementing more sustainable food production practices, leading to a reduced impact on all ecosystems. In this context, the standard methods currently used in these fields represent a sub-optimal solution, being expensive, laboratory-based techniques, and typically requiring trained personnel with high expertise. Recent advances in both biotechnology and material science have led to the emergence of new sensing (and biosensing) technologies, enabling low-cost, precise, and real-time detection. An especially interesting category of biosensors is represented by field-effect transistor-based biosensors (bio-FETs), which enable the possibility of performing in situ, continuous, selective, and sensitive measurements of a wide palette of different parameters of interest. Furthermore, bio-FETs offer the possibility of being fabricated using innovative and sustainable materials, employing various device configurations, each customized for a specific application. In the specific field of environmental and agricultural monitoring, the exploitation of these devices is particularly attractive as it paves the way to early detection and intervention strategies useful to limit, or even completely avoid negative outcomes (such as diseases to animals or ecosystems losses). This review focuses exactly on bio-FETs for environmental and agricultural monitoring, highlighting the recent and most relevant studies. First, bio-FET technology is introduced, followed by a detailed description of the the most commonly employed configurations, the available device fabrication techniques, as well as the specific materials and recognition elements. Then, examples of studies employing bio-FETs for environmental and agricultural monitoring are presented, highlighting in detail advantages and disadvantages of available examples. Finally, in the discussion, the major challenges to be overcome (e.g., short device lifetime, small sensitivity and selectivity in complex media) are critically presented. Despite the current limitations and challenges, this review clearly shows that bio-FETs are extremely promising for new and disruptive innovations in these areas and others.

A Double Dissociation in Sensitivity to Verb and Noun Semantics Across Cortical Networks.

What is the neural organization of the mental lexicon? Previous research suggests that partially distinct cortical networks are active during verb and noun processing, but what information do these networks represent? We used multivoxel pattern analysis (MVPA) to investigate whether these networks are sensitive to lexicosemantic distinctions among verbs and among nouns and, if so, whether they are more sensitive to distinctions among words in their preferred grammatical class. Participants heard 4 types of verbs (light emission, sound emission, hand-related actions, mouth-related actions) and 4 types of nouns (birds, mammals, manmade places, natural places). As previously shown, the left posterior middle temporal gyrus (LMTG+), and inferior frontal gyrus (LIFG) responded more to verbs, whereas the inferior parietal lobule (LIP), precuneus (LPC), and inferior temporal (LIT) cortex responded more to nouns. MVPA revealed a double-dissociation in lexicosemantic sensitivity: classification was more accurate among verbs than nouns in the LMTG+, and among nouns than verbs in the LIP, LPC, and LIT. However, classification was similar for verbs and nouns in the LIFG, and above chance for the nonpreferred category in all regions. These results suggest that the lexicosemantic information about verbs and nouns is represented in partially nonoverlapping networks.

Hierarchical Brain Network for Face and Voice Integration of Emotion Expression.

The brain has separate specialized computational units to process faces and voices located in occipital and temporal cortices. However, humans seamlessly integrate signals from the faces and voices of others for optimal social interaction. How are emotional expressions, when delivered by different sensory modalities (faces and voices), integrated in the brain? In this study, we characterized the brains' response to faces, voices, and combined face-voice information (congruent, incongruent), which varied in expression (neutral, fearful). Using a whole-brain approach, we found that only the right posterior superior temporal sulcus (rpSTS) responded more to bimodal stimuli than to face or voice alone but only when the stimuli contained emotional expression. Face- and voice-selective regions of interest, extracted from independent functional localizers, similarly revealed multisensory integration in the face-selective rpSTS only; further, this was the only face-selective region that also responded significantly to voices. Dynamic causal modeling revealed that the rpSTS receives unidirectional information from the face-selective fusiform face area, and voice-selective temporal voice area, with emotional expression affecting the connection strength. Our study promotes a hierarchical model of face and voice integration, with convergence in the rpSTS, and that such integration depends on the (emotional) salience of the stimuli.

Neural specialization for 'visual' concepts emerges in the absence of vision.

Vision provides a key source of information about many concepts, including 'living things' (e.g., tiger) and visual events (e.g., sparkle). According to a prominent theoretical framework, neural specialization for different conceptual categories is shaped by sensory features, e.g., living things are neurally dissociable from navigable places because living things concepts depend more on visual features. We tested this framework by comparing the neural basis of 'visual' concepts across sighted (n=22) and congenitally blind (n=21) adults. Participants judged the similarity of words varying in their reliance on vision while undergoing fMRI. We compared neural responses to living things nouns (birds, mammals) and place nouns (natural, manmade). In addition, we compared visual event verbs (e.g., 'sparkle') to non-visual events (sound emission, hand motion, mouth motion). People born blind exhibited distinctive univariate and multivariate responses to living things in a temporo-parietal semantic network activated by nouns, including the precuneus (PC). To our knowledge, this is the first demonstration that neural selectivity for living things does not require vision. We additionally observed preserved neural signatures of 'visual' light events in the left middle temporal gyrus (LMTG+). Across a wide range of semantic types, neural representations of sensory concepts develop independent of sensory experience.

Comparative immunomodulatory effects in mice and in human dendritic cells of five bacterial strains selected for biocontrol of leafy green vegetables.

The market for ready-to eat vegetables is increasing, but unfortunately so do the numbers of food-borne illness outbreaks related to these products. A previous study has identified bacterial strains suitable for biocontrol of leafy green vegetables to reduce the exposure to pathogens in these products. As a tentative safety evaluation, five selected strains (Rhodococcus cerastii MR5x, Bacillus coagulans LMG P-32205, Bacillus coagulans LMG P-32206, Pseudomonas cedrina LMG P-32207 and Pseudomonas punonensis LMG P-32204) were individually compared for immunomodulating effects in mice and in human monocyte-derived dendritic cells (MoDCs). Mice receiving the two B. coagulans strains consistently resemble the immunological response of the normal control, and no, or low, cell activation and pro-inflammatory cytokine expression was observed in MoDCs exposed to B. coagulans strains. However, different responses were seen in the two models for the Gram-negative P. cedrina and the Gram-positive R. cerastii. Moreover, P. punonensis and B. coagulans increased the microbiota diversity in mice as seen by the Shannon-Wiener index. In conclusion, the two strains of B. coagulans showed an immunological response that indicate that they lack pathogenic abilities, thus encouraging further safety evaluation and showing great potential to be used as biocontrol agents on leafy green vegetables.

How does a blind person see? Developmental change in applying visual verbs to agents with disabilities.

Classic theories emphasize the primacy of first-person sensory experience for learning meanings of words: to know what "see" means, one must be able to use the eyes to perceive. Contrary to this idea, blind adults and children acquire normative meanings of "visual" verbs, e.g., interpreting "see" and "look" to mean with the eyes for sighted agents. Here we ask the flip side of this question: how easily do sighted children acquire the meanings of "visual" verbs as they apply to blind agents? We asked sighted 4-, 6- and 9-year-olds to tell us what part of the body a blind or a sighted agent would use to "see", "look" (and other visual verbs, n = 5), vs. "listen", "smell" (and other non-visual verbs, n = 10). Even the youngest children consistently reported the correct body parts for sighted agents (eyes for "look", ears for "listen"). By contrast, there was striking developmental change in applying "visual" verbs to blind agents. Adults, 9- and 6-year-olds, either extended visual verbs to other modalities for blind agents (e.g., "seeing" with hands or a cane) or stated that the blind agent "cannot" "look" or "see". By contrast, 4-year-olds said that a blind agent would use her eyes to "see", "look", etc., even while explicitly acknowledging that the agent's "eyes don't work". Young children also endorsed "she is looking at the dax" descriptions of photographs where the blind agent had the object in her "line of sight", irrespective of whether she had physical contact with the object. This pattern held for leg-motion verbs ("walk", "run") applied to wheelchair users. The ability to modify verb modality for agents with disabilities undergoes developmental change between 4 and 6. Despite this, we find that 4-year-olds are sensitive to the semantic distinction between active ("look") and stative ("see"), even when applied to blind agents. These results challenge the primacy of first-person sensory experience and highlight the importance of linguistic input and social interaction in the acquisition of verb meaning.

Bioplastic accumulates antibiotic and metal resistance genes in coastal marine sediments.

The oceans are increasingly polluted with plastic debris, and several studies have implicated plastic as a reservoir for antibiotic resistance genes and a potential vector for antibiotic-resistant bacteria. Bioplastic is widely regarded as an environmentally friendly replacement to conventional petroleum-based plastic, but the effects of bioplastic pollution on marine environments remain largely unknown. Here, we present the first evidence that bioplastic accumulates antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) in marine sediments. Biofilms fouling ceramic, polyethylene terephthalate (PET), and polyhydroxyalkanoate (PHA) were investigated by shotgun metagenomic sequencing. Four ARG groups were more abundant in PHA: trimethoprim resistance (TMP), multidrug resistance (MDR), macrolide-lincosamide-streptogramin resistance (MLS), and polymyxin resistance (PMR). One MRG group was more abundant in PHA: multimetal resistance (MMR). The relative abundance of ARGs and MRGs were strongly correlated based on a Mantel test between the Bray-Curtis dissimilarity matrices (R = 0.97, p < 0.05) and a Pearson's analysis (R = 0.96, p < 0.05). ARGs were detected in more than 40% of the 57 metagenome-assembled genomes (MAGs) while MRGs were detected in more than 90% of the MAGs. Further investigation (e.g., culturing, genome sequencing, antibiotic susceptibility testing) revealed that PHA biofilms were colonized by hemolytic Bacillus cereus group bacteria that were resistant to beta-lactams, vancomycin, and bacitracin. Taken together, our findings indicate that bioplastic, like conventional petroleum-based plastic, is a reservoir for resistance genes and a potential vector for antibiotic-resistant bacteria in coastal marine sediments.

There's more to "sparkle" than meets the eye: Knowledge of vision and light verbs among congenitally blind and sighted individuals.

We examined the contribution of first-person sensory experience to concepts by comparing the meanings of perception (visual/tactile) and emission (light/sound) verbs among congenitally blind (N = 25) and sighted speakers (N = 22). Participants judged semantic similarity for pairs of verbs referring to events of visual (e.g. to peek), tactile (e.g. to feel) and amodal perception (e.g. to perceive) as well as light (e.g. to shimmer) and sound (e.g. to boom) emission and manner of motion (to roll) (total word pairs, N = 2041). Relative to the sighted, blind speakers had higher agreement among themselves on touch perception and sound emission verbs. However, for visual verbs, the judgments of blind and sighted participants were indistinguishable, both in the semantic criteria used and subject-wise variability. Blind and sighted individuals alike differentiate visual perception verbs from verbs of touch and amodal perception and differentiate among acts of visual perception e.g. intense/continuous from brief acts of looking (e.g. peek vs. stare). Light emission verbs are differentiated according to intensity (blaze vs. glow) and stability (blaze vs. flash). Thus detailed knowledge of visual word meanings is acquired without first-person sensory access.

Is there a future for sensory substitution outside academic laboratories?

Sensory substitution devices (SSDs) have been developed with the ultimate purpose of supporting sensory deprived individuals in their daily activities. However, more than forty years after their first appearance in the scientific literature, SSDs still remain more common in research laboratories than in the daily life of people with sensory deprivation. Here, we seek to identify the reasons behind the limited diffusion of SSDs among the blind community by discussing the ergonomic, neurocognitive and psychosocial issues potentially associated with the use of these systems. We stress that these issues should be considered together when developing future devices or improving existing ones. We provide some examples of how to achieve this by adopting a multidisciplinary and participatory approach. These efforts would contribute not solely to address fundamental theoretical research questions, but also to better understand the everyday needs of blind people and eventually promote the use of SSDs outside laboratories.