Detalhe da pesquisa
1.
Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).
Bioorg Med Chem Lett
; 28(3): 541-546, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29254643
2.
Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine.
Bioorg Med Chem Lett
; 26(13): 3202-3206, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27080178
3.
Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine.
Bioorg Med Chem Lett
; 26(13): 3207-3211, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27038498
4.
A1 adenosine receptor antagonists, agonists, and allosteric enhancers.
Handb Exp Pharmacol
; (193): 25-58, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19639278
5.
Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases.
J Med Chem
; 51(7): 2267-78, 2008 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18321039
6.
Selective, high affinity A(2B) adenosine receptor antagonists: N-1 monosubstituted 8-(pyrazol-4-yl)xanthines.
Bioorg Med Chem Lett
; 18(4): 1397-401, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18226896
7.
Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists.
J Med Chem
; 49(12): 3682-92, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16759111
8.
The novel late Na+ current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations.
Br J Pharmacol
; 173(21): 3088-3098, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27449698
9.
Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties.
J Med Chem
; 59(19): 9005-9017, 2016 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27690427
10.
2-Pyrazolyl-N(6)-substituted adenosine derivatives as high affinity and selective adenosine A(3) receptor agonists.
J Med Chem
; 47(19): 4766-73, 2004 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-15341491
11.
A1 adenosine receptor agonists and their potential therapeutic applications.
Expert Opin Investig Drugs
; 17(12): 1901-10, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19012505
12.
N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists.
Bioorg Med Chem Lett
; 17(1): 161-6, 2007 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17045477
13.
Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists.
Bioorg Med Chem Lett
; 16(2): 302-6, 2006 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16275090
14.
Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor.
Bioorg Med Chem Lett
; 12(20): 2935-9, 2002 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12270178
15.
Structure-affinity relationships of 5'-aromatic ethers and 5'-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents.
Bioorg Med Chem Lett
; 14(14): 3793-7, 2004 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15203164
16.
Novel inhibitors of fatty acid oxidation as potential metabolic modulators.
Bioorg Med Chem Lett
; 14(4): 973-7, 2004 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15013004
17.
New fatty acid oxidation inhibitors with increased potency lacking adverse metabolic and electrophysiological properties.
Bioorg Med Chem Lett
; 14(2): 549-52, 2004 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-14698201
18.
CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability.
Bioorg Med Chem Lett
; 14(24): 6017-21, 2004 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15546720