Detalhe da pesquisa
1.
An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.
Nat Chem Biol
; 15(3): 304-313, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30692685
2.
Small-molecule factor D inhibitors targeting the alternative complement pathway.
Nat Chem Biol
; 12(12): 1105-1110, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27775713
3.
Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5.
Angew Chem Int Ed Engl
; 56(5): 1294-1297, 2017 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27981705
4.
Structure-based design and optimization of potent inhibitors of the adenoviral protease.
Bioorg Med Chem Lett
; 25(3): 438-43, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25571794
5.
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Nat Struct Mol Biol
; 13(4): 372-3, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16532006
6.
Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.
ACS Med Chem Lett
; 9(5): 490-495, 2018 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29795765
7.
Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.
J Med Chem
; 60(5): 1946-1958, 2017 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28157311
8.
Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization.
J Mol Biol
; 353(3): 664-77, 2005 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16181639
9.
Purification and crystallization of dengue and West Nile virus NS2B-NS3 complexes.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 62(Pt 2): 157-62, 2006 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16511290
10.
Discovery and structure-based optimization of adenain inhibitors.
ACS Med Chem Lett
; 5(8): 937-41, 2014 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25147618
11.
Mechanism of substrate specificity in Bacillus subtilis ResA, a thioredoxin-like protein involved in cytochrome c maturation.
Proc Natl Acad Sci U S A
; 103(12): 4410-5, 2006 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16537372
12.
Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor.
J Biol Chem
; 280(43): 36047-54, 2005 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16129688
13.
Studies on the relevance of the glycan at Asn-52 of the alpha-subunit of human chorionic gonadotropin in the alphabeta dimer.
Biochem J
; 364(Pt 2): 485-95, 2002 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12023892
14.
Identification and biosynthesis of cyclic enterobacterial common antigen in Escherichia coli.
J Bacteriol
; 185(6): 1995-2004, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12618464
15.
Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor.
Proc Natl Acad Sci U S A
; 100(26): 15504-9, 2003 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-14668441
16.
Cyclic enterobacterial common antigen: potential contaminant of bacterially expressed protein preparations.
J Biomol NMR
; 29(2): 199-204, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15014233