RESUMO
Medical imaging performed in vivo captures geometries under Donnan osmotic loading, even when the articulating joint is otherwise mechanically unloaded. Hence patient-specific finite element (FE) models constructed from such medical images of cartilage represent osmotically induced prestretched/prestressed states. When applying classical modeling approaches to patient-specific simulations of cartilage a theoretical inconsistency arises: the in-vivo imaged geometry (used to construct the model) is not an unloaded, stress-free reference configuration. Furthermore when fitting nonlinear constitutive models that include osmotic swelling (to obtain material parameters), if one assumes that experimental data-generated from osmotically loaded cartilage-begin from a stress-free reference configuration the fitted stress-stretch relationship (parameters) obtained will actually describe a different behavior. In this study we: (1) establish a practical computational method to include osmotically induced prestretch/prestress in image-driven simulations of cartilage; and (2) investigate the influence of considering the prestretched/prestressed state both when fitting fiber-reinforced, biphasic constitutive models of cartilage that include osmotic swelling and when simulating cartilage responses. Our results highlight the importance of determining the prestretched/prestressed state within cartilage induced by osmotic loading in the imaged configuration prior to solving boundary value problems of interest. With our new constitutive model and modeling methods, we aim to improve the fidelity of FE-based, patient-specific biomechanical simulations of joints and cartilage. Improved simulations can provide medical researchers with new information often unavailable in a clinical setting, information that may contribute to better insight into the pathophysiology of cartilage diseases.
Assuntos
Cartilagem , Análise de Elementos Finitos , Osmose , Estresse Mecânico , Fenômenos Biomecânicos , Força CompressivaRESUMO
(1) Background: Vascular tissue seems to adapt towards stable homeostatic mechanical conditions, however, failure of reaching homeostasis may result in pathologies. Current vascular tissue adaptation models use many ad hoc assumptions, the implications of which are far from being fully understood; (2) Methods: The present study investigates the plausibility of different growth kinematics in modeling Abdominal Aortic Aneurysm (AAA) evolution in time. A structurally motivated constitutive description for the vessel wall is coupled to multi-constituent tissue growth descriptions; Constituent deposition preserved either the constituent's density or its volume, and Isotropic Volume Growth (IVG), in-Plane Volume Growth (PVG), in-Thickness Volume Growth (TVG) and No Volume Growth (NVG) describe the kinematics of the growing vessel wall. The sensitivity of key modeling parameters is explored, and predictions are assessed for their plausibility; (3) Results: AAA development based on TVG and NVG kinematics provided not only quantitatively, but also qualitatively different results compared to IVG and PVG kinematics. Specifically, for IVG and PVG kinematics, increasing collagen mass production accelerated AAA expansion which seems counterintuitive. In addition, TVG and NVG kinematics showed less sensitivity to the initial constituent volume fractions, than predictions based on IVG and PVG; (4) Conclusions: The choice of tissue growth kinematics is of crucial importance when modeling AAA growth. Much more interdisciplinary experimental work is required to develop and validate vascular tissue adaption models, before such models can be of any practical use.
RESUMO
We present an approach to model the dispersion of fiber and sheet orientations in the myocardium. By utilizing structure parameters, an existing orthotropic and invariant-based constitutive model developed to describe the passive behavior of the myocardium is augmented. Two dispersion parameters are fitted to experimentally observed angular dispersion data of the myocardial tissue. Computations are performed on a unit myocardium tissue cube and on a slice of the left ventricle indicating that the dispersion parameter has an effect on the myocardial deformation and stress development. The use of fiber dispersions relating to a pathological myocardium had a rather big effect. The final example represents an ellipsoidal model of the left ventricle indicating the influence of fiber and sheet dispersions upon contraction over a cardiac cycle. Although only a minor shift in the pressure-volume (PV) loops between the cases with no dispersions and with fiber and sheet dispersions for a healthy myocardium was observed, a remarkably different behavior is obtained with a fiber dispersion relating to a diseased myocardium. In future simulations, this dispersion model for myocardial tissue may advantageously be used together with models of, for example, growth and remodeling of various cardiac diseases.