RESUMO
Six patients developed severe, unexplained, chronic bronchopulmonary disease from 3 to 13 years after the onset of nonspecific inflammatory disease of the colon. All had chronic bronchitis, bronchiectasis was diagnosed in four, and an obstructive type of pulmonary dysfunction was noted in five. Four of the six, including the two with only chronic bronchitis, had no history of smoking. There was an initial correlation between the pulmonary symptoms and the intestinal disease, except in two patients who developed overt pulmonary disease following total proctocolectomy. The frequent occurence of extraintestinal lesions has suggested that ulcerative colitis and regional enteritis are systemic disorders. Chronic unexplained bronchopulmonary disease may be another infrequent complication in such patients.
Assuntos
Broncopatias/complicações , Colite Ulcerativa/complicações , Doença de Crohn/complicações , Pneumopatias/complicações , Brônquios/patologia , Broncopatias/patologia , Bronquiectasia/patologia , Bronquite/patologia , Doença Crônica , Colite Ulcerativa/patologia , Doença de Crohn/patologia , Feminino , Humanos , Pneumopatias/patologia , Masculino , Pessoa de Meia-Idade , Fatores de TempoRESUMO
Macrophages (monocyte derived) and lymphocytes have been successfully cultured from rabbit peripheral blood so that replicating long-term cultures are maintained both in media and in the viable, frozen state. The macrophages are considered as such on the basis of phagocytic capabilities, gamma-globulin receptor sites as evidenced by rosette formation with sensitized red cells and disparate enzyme content from the lymphocytes.
Assuntos
Técnicas de Cultura/métodos , Linfócitos , Macrófagos , Fosfatase Ácida/sangue , Fosfatase Alcalina/sangue , Aminopeptidases/sangue , Animais , Sítios de Ligação de Anticorpos , Adesão Celular , Linhagem Celular , Separação Celular , Complexo IV da Cadeia de Transporte de Elétrons/sangue , Eritrócitos/imunologia , Imunofluorescência , Congelamento , Galactosidases/sangue , Hexosaminidases/sangue , Reação de Imunoaderência , Linfócitos/enzimologia , Linfócitos/imunologia , Macrófagos/enzimologia , Macrófagos/imunologia , Microscopia Eletrônica , Peptídeo Hidrolases/sangue , Fagocitose , Diester Fosfórico Hidrolases/sangue , Coelhos , Succinato Desidrogenase/sangueRESUMO
The presence of alveolar macrophages in the neonatal lung at the time of autopsy is correlated with the presence of pulmonary lesions and with the duration of postnatal life. Alveolar macrophages were noted at 20 weeks of gestation in infants with congenital pneumonia, but were not present in most full-term infants who were stillborn. They were found in nearly all infants who survived for 48 hours irrespective of pulmonary lesions or gestational age.
Assuntos
Macrófagos/patologia , Alvéolos Pulmonares/citologia , Feminino , Morte Fetal , Idade Gestacional , Humanos , Recém-Nascido , Recém-Nascido Prematuro , Recém-Nascido Pequeno para a Idade Gestacional , Pneumopatias/patologia , Masculino , Pneumonia/congênito , Gravidez , Fatores de TempoRESUMO
Trisomy 7 was detected in umbilical cord cells cultured from a fetus with renal dysplasia. Skin fibroblasts were diploid. Because of a paucity of liveborn infants with full trisomy 7, the phenotype is not well described; however renal anomalies appear to be common with trisomy 7.