Detalhe da pesquisa
1.
Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Annu Rev Pharmacol Toxicol
; 58: 65-82, 2018 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29029591
2.
New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop.
Regul Toxicol Pharmacol
; 114: 104668, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32335207
3.
Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid.
Arch Toxicol
; 93(4): 1021-1037, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30915487
4.
The value of integrating pre-clinical data to predict nausea and vomiting risk in humans as illustrated by AZD3514, a novel androgen receptor modulator.
Toxicol Appl Pharmacol
; 296: 10-8, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26876616
5.
Assessing the predictive value of the rodent neurofunctional assessment for commonly reported adverse events in phase I clinical trials.
Regul Toxicol Pharmacol
; 80: 348-57, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27155597
6.
Beyond the hype and toward application: liver complex in vitro models in preclinical drug safety.
Expert Opin Drug Metab Toxicol
; : 1-13, 2024 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38465923
7.
From animal testing to in vitro systems: advancing standardization in microphysiological systems.
Lab Chip
; 24(5): 1076-1087, 2024 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38372151
8.
Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems.
Stem Cell Reports
; 19(1): 37-40, 2024 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38134927
9.
Integrating Liver-Chip data into pharmaceutical decision-making processes.
Expert Opin Drug Discov
; 18(12): 1313-1320, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37700537
10.
Safety Profiling of Tumor-targeted T Cell-Bispecific Antibodies with Alveolus Lung- and Colon-on-Chip.
Bio Protoc
; 13(1)2023 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36789090
11.
Optimal experimental design for efficient toxicity testing in microphysiological systems: A bone marrow application.
Front Pharmacol
; 14: 1142581, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37063297
12.
Physiological Replication of the Human Glomerulus Using a Triple Culture Microphysiological System.
Adv Sci (Weinh)
; 10(33): e2303131, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37867234
13.
The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds.
Toxicol Appl Pharmacol
; 263(2): 171-83, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22714037
14.
Refinement of the charcoal meal study by reduction of the fasting period.
Altern Lab Anim
; 40(2): 99-107, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22762194
15.
Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality.
J Vis Exp
; (183)2022 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35604153
16.
The Future of Uncertainty Factors With In Vitro Studies Using Human Cells.
Toxicol Sci
; 186(1): 12-17, 2022 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34755872
17.
Co-Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver-Chip for the Study of Drug-Induced Liver Injury.
Curr Protoc
; 2(7): e478, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-35790095
18.
A microengineered Brain-Chip to model neuroinflammation in humans.
iScience
; 25(8): 104813, 2022 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35982785
19.
Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology.
Commun Med (Lond)
; 2(1): 154, 2022 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36473994
20.
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption.
Nat Commun
; 12(1): 5907, 2021 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34625559