Detalhe da pesquisa
1.
A fluorogenic substrate for the detection of lipid amidases in intact cells.
J Lipid Res
; 65(3): 100520, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38369184
2.
CCR5 deficiency impairs CD4+ T-cell memory responses and antigenic sensitivity through increased ceramide synthesis.
EMBO J
; 39(15): e104749, 2020 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32525588
3.
Targeting dihydroceramide desaturase 1 (Des1): Syntheses of ceramide analogues with a rigid scaffold, inhibitory assays, and AlphaFold2-assisted structural insights reveal cyclopropenone PR280 as a potent inhibitor.
Bioorg Chem
; 145: 107233, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38422591
4.
High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase.
J Enzyme Inhib Med Chem
; 38(1): 343-348, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36519337
5.
Fluorescently Labeled Ceramides and 1-Deoxyceramides: Synthesis, Characterization, and Cellular Distribution Studies.
J Org Chem
; 87(24): 16351-16367, 2022 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36441972
6.
Methuosis Contributes to Jaspine-B-Induced Cell Death.
Int J Mol Sci
; 23(13)2022 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35806262
7.
Synthesis and characterization of bichromophoric 1-deoxyceramides as FRET probes.
Org Biomol Chem
; 19(11): 2456-2467, 2021 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33650618
8.
Diets with Higher ω-6/ω-3 Ratios Show Differences in Ceramides and Fatty Acid Levels Accompanied by Increased Amyloid-Beta in the Brains of Male APP/PS1 Transgenic Mice.
Int J Mol Sci
; 22(20)2021 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34681567
9.
A Mechanism-Based Sphingosine-1-phosphate Lyase Inhibitor.
J Org Chem
; 85(2): 419-429, 2020 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31860798
10.
New fluorogenic probes for neutral and alkaline ceramidases.
J Lipid Res
; 60(6): 1174-1181, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926626
11.
Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells.
J Lipid Res
; 60(9): 1590-1602, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31363040
12.
Activity-Based Imaging of Acid Ceramidase in Living Cells.
J Am Chem Soc
; 141(19): 7736-7742, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31030513
13.
Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities.
Am J Pathol
; 187(4): 864-883, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28342444
14.
Clearly Detectable, Kinetically Restricted Solid-Solid Phase Transition in cis-Ceramide Monolayers.
Langmuir
; 34(39): 11749-11758, 2018 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30183303
15.
Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid-ß Levels in Primary Neurons from an Alzheimer's Disease Transgenic Model.
Pharm Res
; 35(3): 49, 2018 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29411122
16.
Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase.
J Lipid Res
; 58(8): 1500-1513, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28572516
17.
Dihydroceramide desaturase inhibitors induce autophagy via dihydroceramide-dependent and independent mechanisms.
Biochim Biophys Acta Gen Subj
; 1861(2): 264-275, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27894925
18.
Coordinated regulation of the orosomucoid-like gene family expression controls de novo ceramide synthesis in mammalian cells.
J Biol Chem
; 290(5): 2822-30, 2015 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-25519910
19.
De novo ceramide synthesis is involved in acute inflammation during labor.
Biol Chem
; 397(2): 147-55, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26501163
20.
Effect of prenatal steroidal inhibition of sPLA2 in a rat model of preterm lung.
Pulm Pharmacol Ther
; 36: 31-6, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26704083