RESUMO
A key mechanism by which the prefrontal cortex (PFC) supports goal-oriented behaviors is attentional set formation: the formation and maintenance of an attentional bias toward relevant features. It has previously been proposed that a common single nucleotide polymorphism (val158met) in the gene that codes for the catechol O-methyltransferase (COMT) enzyme may affect an individual's ability to form and maintain an attentional set by modulating PFC dopamine (DA) levels. Here, we present data from a functional magnetic resonance imaging study that investigated the effect of this polymorphism on the tendency for older adults to display set-like behavior, and we compare these results to preexisting data from Parkinson's Disease (PD) patients. Our results demonstrate that putatively different levels of PFC DA predict both attentional set formation and right dorsolateral PFC (DLPFC) activation. More specifically, while for PD patients, val homozygotes showed heightened DLPFC activation and increased set-like behavior, for healthy older adults, the opposite pattern of results was observed. This interaction between COMT genotype and PD accords well with previous studies that have shown an excess of DA in the PFC in early PD patients and, furthermore, supports the hypothesis that there is an inverted-U shaped functional relationship between PFC DA levels and attentional set formation.
Assuntos
Catecol O-Metiltransferase/genética , Cognição/fisiologia , Dopamina/metabolismo , Córtex Pré-Frontal/metabolismo , Idoso , Atenção/fisiologia , Dopamina/genética , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Doença de Parkinson/genética , Doença de Parkinson/psicologia , Polimorfismo de Nucleotídeo Único , Córtex Pré-Frontal/químicaRESUMO
Radiocarbon dating is a useful tool in the examination of unknown human remains. Recent studies have shown that the analysis of hair and nail samples can provide a highly accurate estimation of the year of death (YOD). However, little research has examined factors that may influence the uptake and storage of 14C in these tissues, such as diet, or the use of beauty products. This study measured the level of 14C in human hair and nail samples collected from living individuals to determine whether diet, and the use of hair dye or nail polish, has a significant impact on the estimation of YOD. The results of this study showed that diet did not appear to impact the radiocarbon content in human hair and nail, and thus should not be considered a limitation when analysing samples obtained from unidentified human remains. The use of nail polish, and in the majority of cases, hair dye, did not significantly impact the 14C concentration in nails and hair. While the results of this study are preliminary, they suggest that in most cases, both hair and nail can be successfully analysed using radiocarbon dating to estimate an individual's YOD. However, best practice should involve the analysis of multiple tissue types, to minimise any error that may be introduced as a result of the decedent's use of beauty products.
Assuntos
Bombas (Dispositivos Explosivos) , Tinturas para Cabelo , Humanos , Unhas , Restos Mortais , Dieta , CabeloRESUMO
The radiocarbon (14C) analysis of skeletonised human remains can provide vital information regarding the time since death. This study analysed the 14C content in both cortical and trabecular bone from the femur and rib of 18 human remains donated to the Australian Facility for Taphonomic Experimental Research. To determine the most appropriate bone to sample for 14C analysis when estimating the time since death, differences in turnover time between the bone types, and the difference between environmental 14C during the year of death (YOD) and the level of 14C found within the bone (i.e., the lag time) were examined. Overall, the average lag time for all donors was 25 years, with the cortical bone from femur samples providing the largest lag time (39 years) and the trabecular bone from rib samples containing the lowest level of 14C (most modern), with an average lag time of 13 years. The results of this study suggest that in cases of unidentified human remains, the analysis of trabecular bone from a rib may be preferred sample, as this bone contains the most recent 14C, and can provide an estimate of both the time since death, and a broad approximation of YOD.
Assuntos
Restos Mortais , Osso e Ossos , Humanos , Radioisótopos de Carbono/análise , Austrália , Osso e Ossos/química , Fêmur/químicaRESUMO
When human remains are discovered, confirming the identification of the decedent is the first part of the forensic medical investigation. In cases where the remains are skeletonised or badly decomposed, differential preservation often increases the difficulty of this task. Bomb pulse dating, which directly compares levels of 14 C within human tissues to atmospheric levels, can provide an estimate of the year of death, which may assist in the identification process. This study measured the 14 C content in samples of hair, nail and puparia collected from donors at the Australian Facility for Taphonomic Experimental Research (AFTER). The radiocarbon results demonstrated that the nail samples provided the most accurate year of death estimation, with 91% correctly predicting YOD, closely followed by hair, with a 79% correct prediction rate, with both hair and nails having a lag time of 0-1 years. This is consistent with the time taken for atmospheric CO 2 to enter the food chain, and be taken in by humans. Puparia was found to have the highest levels of 14 C, and was the least consistent with the actual YOD (46% correct). However, predicted YOD ranges were still within 4 years of the actual YOD. Based on the results of this study, hair, nail and puparia should be considered as useful samples to obtain accurate estimates for YOD using bomb pulse dating.
Assuntos
Bombas (Dispositivos Explosivos) , Datação Radiométrica , Austrália , Radioisótopos de Carbono/análise , Humanos , Unhas/químicaRESUMO
The last deglacial was an interval of rapid climate and sea-level change, including the collapse of large continental ice sheets. This database collates carefully assessed sea-level data from peer-reviewed sources for the interval 0 to 25 thousand years ago (ka), from the Last Glacial Maximum to the present interglacial. In addition to facilitating site-specific reconstructions of past sea levels, the database provides a suite of data beyond the range of modern/instrumental variability that may help hone future sea-level projections. The database is global in scope, internally consistent, and contains U-series and radiocarbon dated indicators from both biological and geomorpohological archives. We focus on far-field data (i.e., away from the sites of the former continental ice sheets), but some key intermediate (i.e., from the Caribbean) data are also included. All primary fields (i.e., sample location, elevation, age and context) possess quantified uncertainties, which-in conjunction with available metadata-allows the reconstructed sea levels to be interpreted within both their uncertainties and geological context.
RESUMO
A slice from a Porites Lutea coral core collected inside the Enewetak Atoll lagoon, within 15 km of all major nuclear tests conducted at the atoll, was analysed for 236U, 239Pu and 240Pu over the time interval 1952-1964 using a higher time resolution than previously reported for a parallel slice from the same core. In addition two sediment samples from the Koa and Oak craters were analysed. The strong peaks in the concentrations of 236U and 239Pu in the testing years are confirmed to be considerably wider than the flushing time of the lagoon. This is likely due to the growth mechanism of the coral. Following the last test in 1958 atom concentrations of both 236U and 239Pu decreased from their peak values by more than 95% and showed a seasonal signal thereafter. Between 1959 and 1964 the weighted average of the 240Pu/239Pu atom ratio is 0.124 ± 0.008 which is similar to that in the lagoon sediments (0.129 ± 0.006) but quite distinct from the global fallout value of â¼0.18. This, and the high 239,240Pu and 236U concentrations in the sediments, provides clear evidence that the post-testing signal in the coral is dominated by remobilisation of the isotopes from the lagoon sediments rather than from global fallout.
Assuntos
Armas Nucleares , Plutônio/análise , Monitoramento de Radiação , Cinza Radioativa/análise , Urânio/análise , Poluentes Radioativos da Água/análiseRESUMO
A comprehensive series of nuclear tests were carried out by the United States at Enewetak Atoll in the Marshall Islands, especially between 1952 and 1958. A Porites Lutea coral that was growing in the Enewetak lagoon within a few km of all of the high-yield tests contains a continuous record of isotopes, which are of interest (e.g. 14C, 236U, 239,240Pu) through the testing period. Prior to the present work, 14C measurements at â¼2-month resolution had shown pronounced peaks in the Δ14C data that coincided with the times at which tests were conducted. Here we report measurements of 236U and 239,240Pu on the same coral using accelerator mass spectrometry, and again find prominent peaks in the concentrations of these isotopes that closely follow those in 14C. Consistent with the 14C data, the magnitudes of these peaks do not, however, correlate well with the explosive yields of the corresponding tests, indicating that smaller tests probably contributed disproportionately to the debris that fell in the lagoon. Additional information about the different tests can also be obtained from the 236U/239Pu and 240Pu/239Pu ratios, which are found to vary dramatically over the testing period. In particular, the first thermonuclear test, Ivy-Mike, has characteristic 236U/239Pu and 240Pu/239Pu signatures which are diagnostic of the first arrival of nuclear test material in various archives.
Assuntos
Antozoários/química , Plutônio/análise , Monitoramento de Radiação , Poluentes Radioativos da Água/análise , Animais , Micronésia , Armas Nucleares , Cinza Radioativa/análiseRESUMO
Planning, the decomposition of an ultimate goal into a number of sub-goals is critically dependent upon fronto-striatal dopamine (DA) levels. Here, we examined the extent to which the val158met polymorphism in the catechol O-methyltransferase (COMT) gene, which is thought to primarily alter cortical DA levels, affects performance and fronto-parietal activity during a planning task (Tower of London). COMT genotype was found to modulate activity in the left superior posterior parietal cortex (SPC) during planning, relative to subtracting, trials. Specifically, left SPC blood oxygenation level-dependent (BOLD) response was reduced in groups with putatively low or high cortical DA levels (COMT homozygotes) relative to those with intermediate cortical DA levels (COMT heterozygotes). These set of results are argued to occur either due to differences in neuronal processing in planning (and perhaps subtracting) caused by the COMT genotype and/or the cognitively heterogeneous nature of the TOL, which allows different cognitive strategies to be used whilst producing indistinguishable behavioural performance in healthy adults. The implications of this result for our understanding of COMT's effect on cognition in health and disease are discussed.
Assuntos
Catecol O-Metiltransferase/genética , Córtex Cerebral/fisiologia , Dopamina/metabolismo , Resolução de Problemas/fisiologia , Idoso , Catecol O-Metiltransferase/metabolismo , Córtex Cerebral/metabolismo , Feminino , Neuroimagem Funcional , Genótipo , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Polimorfismo de Nucleotídeo Único , Tempo de Reação/fisiologiaRESUMO
We describe a previously unknown assemblage of seamount-associated megabenthos that has by far the highest peak biomass reported in the deep-sea outside of vent communities. The assemblage was found at depths of 2-2.5 km on rocky geomorphic features off the southeast coast of Australia, in an area near the Sub-Antarctic Zone characterised by high rates of surface productivity and carbon export to the deep-ocean. These conditions, and the taxa in the assemblage, are widely distributed around the Southern mid-latitudes, suggesting the high-biomass assemblage is also likely to be widespread. The role of this assemblage in regional ecosystem and carbon dynamics and its sensitivities to anthropogenic impacts are unknown. The discovery highlights the lack of information on deep-sea biota worldwide and the potential for unanticipated impacts of deep-sea exploitation.