Detalhe da pesquisa
1.
Targeting the tubulin C-terminal tail by charged small molecules.
Org Biomol Chem
; 21(1): 153-162, 2022 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36472095
2.
Discovery of 12ß-oxygenated oleanolic acid alkyl esters as potent and selective FXR modulators exhibiting hyperglycemia amelioration in vivo.
Bioorg Chem
; 129: 106203, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36265352
3.
Taxanes convert regions of perturbed microtubule growth into rescue sites.
Nat Mater
; 19(3): 355-365, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31819210
4.
Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR.
Bioorg Chem
; 92: 103253, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31557620
5.
Synthesis and Cytotoxicity of 7,9-O-Linked Macrocyclic C-Seco Taxoids.
Molecules
; 24(11)2019 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31181726
6.
Extensive Structure Modification on Luteolin-Cinnamic Acid Conjugates Leading to BACE1 Inhibitors with Optimal Pharmacological Properties.
Molecules
; 25(1)2019 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31888099
7.
A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility.
J Nat Prod
; 81(3): 524-533, 2018 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29359935
8.
An efficient semi-synthesis of 1-hydroxyl oleanolic acid analogs.
J Asian Nat Prod Res
; 19(6): 595-601, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28393564
9.
Discovery of Farnesoid X Receptor Antagonists Based on a Library of Oleanolic Acid 3-O-Esters through Diverse Substituent Design and Molecular Docking Methods.
Molecules
; 22(5)2017 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28445411
10.
Inhibiting the proliferation, migration and invasion of triple negative breast cancer cells through anti-tumor human serum albumin nanoparticles loading aziditaxel as a novel taxane derivative.
Pharmazie
; 72(3): 152-160, 2017 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29442050
11.
A novel C,D-spirodioxene taxoid synthesized through an unexpected Pd-mediated ring cyclization.
Org Biomol Chem
; 14(1): 345-52, 2016 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26603551
12.
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
Bioorg Med Chem
; 22(18): 5078-90, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25047938
13.
A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.
Org Biomol Chem
; 11(18): 3046-56, 2013 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23532250
14.
Structural insight into the stabilization of microtubules by taxanes.
Elife
; 122023 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36876916
15.
Modulation of taxane binding to tubulin curved and straight conformations by systematic 3'N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency.
Eur J Med Chem
; 259: 115668, 2023 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37490800
16.
New ursane-type triterpene with NO production suppressing activity from Nauclea officinalis.
J Asian Nat Prod Res
; 14(2): 97-104, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22296148
17.
Isolation, identification, semi-synthesis of aziditaxel derivatives and their biological evaluation.
J Asian Nat Prod Res
; 14(5): 463-75, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22530674
18.
Structure Modification of FXR Antagonistic Chalcones and Their Inhibitory Effects on NSCLC Cell Proliferation and Metastasis.
ChemMedChem
; 17(11): e202100778, 2022 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35274459
19.
Modulation of microtubule interprotofilament interactions by modified taxanes.
Biophys J
; 101(12): 2970-80, 2011 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22208196
20.
Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport.
Bioorg Med Chem Lett
; 21(16): 4852-6, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21764308