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1.
Ann Thorac Surg ; 113(6): 2097-2101, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35051396

RESUMO

Mitral stenosis was first described in 1674 by Englishman John Mayow, but surgical intervention for mitral stenosis was proposed over 2 centuries later in 1898. Mitral valve surgery was undertaken in the 1920s with varying success; after 2 decades of staggered progress, mitral valvuloplasty and commissurotomy would be rediscovered by Americans Horace Smithy, Charles Bailey, and Dwight Harken. The evolution of open surgery for mitral stenosis suggests the troubled triumph of humanity over disease while also underlining surgeons' inability to successfully disseminate their pioneering ideas to a community critical of innovation.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Estenose da Valva Mitral , Cirurgiões , Procedimentos Cirúrgicos Cardíacos/história , Humanos , Estenose da Valva Mitral/cirurgia
2.
J Thorac Cardiovasc Surg ; 163(4): 1419-1427, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34334173

RESUMO

OBJECTIVE: The study objective was to evaluate the experience of previous American Association for Thoracic Surgery Summer Intern Scholarship recipients. METHODS: A database of recipients of the American Association for Thoracic Surgery Summer Intern Scholarship in Cardiothoracic Surgery provided by the American Association for Thoracic Surgery was analyzed. A questionnaire was sent via email to recipients with 10 questions within the survey to assess the types of exposure during the internship, the impact of the internship on career choices, the current career setting, and any additional thoughts regarding the internship. RESULTS: Between 2007 and 2017, there were 356 awardees of the American Association for Thoracic Surgery Summer Intern Scholarship. These awardees were from 41 different medical schools and went to 39 different sponsoring institutions. Ultimately, 55 (15.5%) medical students chose a career in cardiothoracic surgery, with 153 (43.0%) awardees deciding to pursue a surgical subspecialty. Of those who received our survey, 75 awardees responded (29.2%). A majority of the American Association for Thoracic Surgery Summer Interns were exposed to the sponsoring surgeon (98.7%, n = 74) and operating room (88.0%, n = 66) on at least a weekly basis during the 8-week internship. All of the respondents participated in basic science or clinical research at their sponsoring institution. Some 92.0% (n = 69) of the awardees highly recommended this scholarship to medical students interested in cardiothoracic surgery. CONCLUSIONS: The awardees of the American Association for Thoracic Surgery Summer Intern Scholarship come from a variety of medical schools and visited a diverse group of sponsoring institutions. The 8-week program provides valuable early exposure for medical students to cardiothoracic surgeons, the operating room, and research opportunities. This experience was highly recommended by prior recipients to medical students interested in cardiothoracic surgery.


Assuntos
Escolha da Profissão , Bolsas de Estudo/estatística & dados numéricos , Estudantes de Medicina/estatística & dados numéricos , Cirurgia Torácica/educação , Adolescente , Adulto , Feminino , Humanos , Masculino , Sociedades Médicas , Inquéritos e Questionários , Estados Unidos , Adulto Jovem
3.
Ann Thorac Surg ; 2022 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-35934065

RESUMO

BACKGROUND: The COVID-19 pandemic has disrupted components of traditional education with shifts toward virtual platforms. This report describes the virtual approach to basic surgical skills training during a high school program in the summers of 2020 and 2021. METHODS: Two 2-week sessions were held by Zoom (Zoom Video Communications) with 99 students in 2020 and 198 students in 2021. Each student was sent surgical supplies and instruments. Interactive lectures were held each morning, and basic surgical skills instruction was provided each afternoon. After the session, survey links were distributed to students to complete an anonymous 37-item questionnaire regarding surgical skills confidence, simulation kit satisfaction, and technical difficulties. RESULTS: Of the 297 students, 270 (90.9%) completed the questionnaire, including 91 (91.9%) in 2020 and 179 (90.4%) in 2021. On a scale of 1 (fair) to 5 (excellent), students in 2020 and 2021 reported similar confidence in instrument handling (4-5: 90.0% vs 86.3%; P = .38), suturing skin (4-5: 88.9% vs 82.8%; P = .19), and thoracic aorta suturing (4-5: 73.3% vs 73.6%; P = .97). Students reported greater confidence in 2020 in knot tying (4-5: 98.9% vs 87.9%; P = .002), coronary vessel suturing (4-5: 82.2% vs 65.5%; P < .001), and valve model suturing (4-5: 68.5% vs 50.3%; P = .005) than students in 2021. Students had similar satisfaction rates with the program (extremely or somewhat satisfied: 92.3% vs 86.0%; p = .51) between 2020 and 2021. CONCLUSIONS: Virtual education carries the potential for basic surgical skills training for a more widespread audience with less access to direct surgical education. Further research is needed to optimize teaching finer surgical skills.

4.
Ann Thorac Surg ; 110(2): 364-372, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32268139

RESUMO

The burgeoning demands for quality, safety, and value in cardiothoracic surgery, in combination with the advancement and acceleration of digital health solutions and information technology, provide a unique opportunity to improve efficiency and effectiveness simultaneously in cardiothoracic surgery. This primer on digital health explores and reviews data integration, data processing, complex modeling, telehealth with remote monitoring, and cybersecurity as they shape the future of cardiothoracic surgery.


Assuntos
Telemedicina , Cirurgia Torácica , Procedimentos Cirúrgicos Torácicos , Inteligência Artificial , Simulação por Computador , Humanos , Cirurgia Torácica/métodos , Cirurgia Torácica/normas , Procedimentos Cirúrgicos Torácicos/métodos , Procedimentos Cirúrgicos Torácicos/normas
5.
Artigo em Inglês | MEDLINE | ID: mdl-31955931

RESUMO

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.

6.
Thorac Surg Clin ; 29(3): 339-350, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31235303

RESUMO

Artificial intelligence (AI) is being rapidly integrated into various medical applications. Although early application of AI has been achieved in image-based, as well as statistical computational models, translation into procedure-based specialties such as surgery may take longer to achieve. A potential application of AI in surgical education is as a teaching coach or mentor that interacts with the used via virtual and/or augmented reality. The question arises as to whether machines will achieve the wisdom and intelligence of human educators.


Assuntos
Inteligência Artificial , Cirurgia Geral/educação , Tutoria/métodos , Ensino , Humanos , Realidade Virtual
7.
Ann Thorac Surg ; 108(6): 1895-1900, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31336069

RESUMO

BACKGROUND: Previous "high-stakes" examinations by the American Board of Thoracic Surgery (ABTS) required remote testing, were noneducational, and were not tailored to individual practices. Given the ABTS mission of public safety and diplomate education, the ABTS Maintenance of Certification (MOC) examination was revised in 2015 to improve the educational experience and validate knowledge acquired. METHODS: The ABTS-MOC Committee developed a web-based, secure examination tailored to the specialty-specific practice profile (cardiac, general thoracic, cardiothoracic, congenital) of the individual surgeon. After an initial answer to each question, an educational critique was reviewed before returning to the initial question and logging a second (final) response. Intraexam learning was assessed by comparing scores before and after reading the critique. Diplomate feedback was obtained. RESULTS: A total of 988 diplomates completed the 10-year MOC examination between 2015 and 2017. Substantive learning was demonstrated with an 18%, 17%, 20%, and 9% improvement in cardiac, general thoracic, cardiothoracic, and congenital final scores, respectively. This improvement was most notable among diplomates with the lowest initial scores. Fewer diplomates failed the new exam (<1% vs 2.3%). Diplomate postexam survey highlighted marked improvements in clinical relevance (35% vs 78%), convenience (37% vs 78%), and learning (15% vs 45%). Over 80% acknowledged educational value, and 97% preferred the new format. CONCLUSIONS: The new MOC process demonstrates increased knowledge acquisition through a convenient, secure, web-based practice-focused examination. This approach provides feedback, identifies baseline knowledge gaps for individual diplomates, and validates new knowledge attained.


Assuntos
Certificação , Competência Clínica , Educação de Pós-Graduação em Medicina/normas , Conselhos de Especialidade Profissional , Cirurgia Torácica/educação , Procedimentos Cirúrgicos Torácicos/normas , Avaliação Educacional , Humanos , Estudos Retrospectivos , Procedimentos Cirúrgicos Torácicos/educação , Estados Unidos
8.
Catheter Cardiovasc Interv ; 71(3): 434-40, 2008 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-18288759

RESUMO

To decrease the morbidity associated with conventional surgery for calcific aortic stenosis, there has been increasing interest in catheter-based treatment using a stent or frame mounted bioprosthetic valve. Critical to its success is knowledge of pathoanatomy, risk of embolization of calcific debris, and issues associated with device anchoring and paravalvular leaks. In the absence of a chronic animal model of aortic stenosis, development of a catheter-based device has been an iterative process based on experimental and early clinical data gathered abroad, where marketing may be permitted with less clinical data than required in the United States. This process has persuaded many companies to circumvent the time delays occasioned by the FDA regulatory validation of iterative design changes by performing initial studies outside the United States. Because percutaneous aortic valve replacement is considered a Class III device, premarket approval, including defining the patient population, inclusion and exclusion criteria, control population, and interpretable clinical endpoints, is required. In the early clinical experience, percutaneous aortic valve replacement has been directed at high-risk patients who were considered "very poor" or "non-surgical" candidates. Defining and identifying patients for the clinical trial may be challenging, in part because of the difficult selection of an appropriate control group, e.g., conventional aortic valve replacement, best medical management, and/or balloon valvuloplasty.


Assuntos
Cateterismo/métodos , Doenças das Valvas Cardíacas/diagnóstico , Doenças das Valvas Cardíacas/terapia , Próteses Valvulares Cardíacas , Animais , Insuficiência da Valva Aórtica/terapia , Estenose da Valva Aórtica/terapia , Bioprótese , Cateterismo/efeitos adversos , Previsões , Implante de Prótese de Valva Cardíaca/normas , Implante de Prótese de Valva Cardíaca/tendências , Humanos , Medição de Risco , Resultado do Tratamento
9.
J Card Surg ; 23(6): 773-6, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-19017010

RESUMO

Congenital coronary anomalies can be found in up to 1% of patients undergoing angiography. The most severe of these lesions become symptomatic in early childhood, while others can remain without consequence. However, while being silent in the early decades of life, these asymptomatic anomalies can contribute to the presentation of acquired heart disease and can themselves become clinically significant. We describe the clinical course of two patients with congenital coronary artery anomalies presenting beyond the fifth decade of life with concurrent acquired heart disease.


Assuntos
Anomalias dos Vasos Coronários/complicações , Anomalias dos Vasos Coronários/diagnóstico , Cardiopatias/complicações , Cardiopatias/diagnóstico , Estenose da Valva Aórtica/etiologia , Fístula Artério-Arterial/patologia , Fístula Artério-Arterial/cirurgia , Estenose Coronária/patologia , Estenose Coronária/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Artéria Pulmonar/patologia , Artéria Pulmonar/cirurgia
11.
J Thorac Cardiovasc Surg ; 156(2): 922-927, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29764685

RESUMO

OBJECTIVE: Web-based curricula provide login data that can be advantageously used to characterize and analyze study habits. We sought to compare thoracic surgical trainee In-Training Examination percentiles with regard to their study habits (ie, cramming), as characterized by curriculum login frequency to the national Web-based Thoracic Surgery Curriculum. Furthermore, we then aimed to characterize the curriculum login frequency of trainees as stratified by their performance on the In-Training Examination and their improvement on the In-Training Examination over subsequent years. METHODS: We performed a retrospective review of trainees who accessed the curriculum before the 2014 In-Training Examination, with curriculum login data collected from site analytics. Scores were compared between trainees who crammed (≥30% increase in logins in the month before the In-Training Examination) and those who did not. Trainees were stratified on the basis of 2014 In-Training Examination percentile and improvement in percentile from 2013 to 2014 into high, medium, and low scorers and improvers. RESULTS: Of 256 trainees who took the 2014 In-Training Examination, 63 (25%) met criteria as crammers. Crammers increased total study sessions immediately before the In-Training Examination (P < .001), but without impact on 2014 In-Training Examination percentile (P = .995) or year-to-year improvement (P = .234). Stratification by In-Training Examination percentile demonstrated that highest scoring trainees used the curriculum more frequently in the final month than medium-range scorers (P = .039). When stratified by extent of year-to-year improvement, those who improved the most accessed the curriculum significantly more often in the last month compared with baseline (P = .040). Moreover, those with greatest improvement logged in more in the final month than those with least improvement (P = .006). CONCLUSIONS: Increasing the frequency of study periods on the national Web-based thoracic surgery curriculum before the In-Training Examination may have a unique benefit to trainees who initially score low to allow them to significantly improve their subsequent year In-Training Examination performance.


Assuntos
Competência Clínica/estatística & dados numéricos , Educação de Pós-Graduação em Medicina/métodos , Internet/estatística & dados numéricos , Cirurgia Torácica/educação , Procedimentos Cirúrgicos Torácicos/educação , Currículo , Avaliação Educacional , Humanos , Estudos Retrospectivos
12.
Ann Thorac Surg ; 104(4): 1117-1122, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28935298

RESUMO

Despite increasing recognition of physician burnout, its incidence has only increased in recent years, with nearly half of physicians suffering from symptoms of burnout in the most recent surveys. Unfortunately, most burnout research has focused on its profound prevalence rather than seeking to identify the root cause of the burnout epidemic. Health care organizations throughout the United States are implementing committees and support groups in an attempt to reduce burnout among their physicians, but these efforts are typically focused on increasing resilience and wellness among participants rather than combating problematic changes in how medicine is practiced by physicians in the current era. This report provides a brief review of the current literature on the syndrome of burnout, a summary of several institutional approaches to combating burnout, and a call for a shift in the focus of these efforts toward one proposed root cause of burnout.


Assuntos
Esgotamento Profissional/epidemiologia , Esgotamento Profissional/prevenção & controle , Médicos/psicologia , Carga de Trabalho , Adaptação Psicológica , Humanos , Avaliação das Necessidades , Prevalência , Medição de Risco , Estresse Psicológico , Inquéritos e Questionários , Estados Unidos
13.
Ann Thorac Surg ; 103(1): 322-328, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27570163

RESUMO

BACKGROUND: The Cardiac Surgery Simulation Curriculum was developed at 8 institutions from 2010 to 2013. A total of 27 residents were trained by 18 faculty members. A survey was conducted to gain insight into the initial experience. METHODS: Residents and faculty were sent a 72- and 68-question survey, respectively. In addition to demographic information, participants reported their view of the overall impact of the curriculum. Focused investigation into each of the 6 modules was obtained. Participants evaluated the value of the specific simulators used. Institutional biases regarding implementation of the curriculum were evaluated. RESULTS: Twenty (74%) residents and 14 (78%) faculty responded. The majority (70%) of residents completed this training in their first and second year of traditional-track programs. The modules were well regarded with no respondents having an unfavorable view. Both residents and faculty found low, moderate, and high fidelity simulators to be extremely useful, with particular emphasis on utility of high fidelity components. The vast majority of residents (85%) and faculty (100%) felt more comfortable in the resident skill set and performance in the operating room. Simulation of rare adverse events allowed for development of multidisciplinary teams to address them. At most institutions, the conduct of this curriculum took precedence over clinical obligations (64%). CONCLUSIONS: The Cardiac Surgery Simulation Curriculum was implemented with robust adoption among the investigating centers. Both residents and faculty viewed the modules favorably. Using this curriculum, participants indicated an improvement in resident technical skills and were enthusiastic about training in adverse events and crisis management.


Assuntos
Procedimentos Cirúrgicos Cardíacos/educação , Simulação por Computador , Currículo , Educação de Pós-Graduação em Medicina/métodos , Docentes/estatística & dados numéricos , Internato e Residência/métodos , Cirurgia Torácica/educação , Adulto , Competência Clínica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários
14.
Ann Thorac Surg ; 103(1): 312-321, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27570162

RESUMO

BACKGROUND: Operating room surgical training has significant limitations. This study hypothesized that some skills could be learned efficiently and safely by using simulation with component task training, deliberate practice, progressive complexity, and experienced coaching to produce safer cardiac surgeons. METHODS: Training modules included cardiopulmonary bypass, coronary artery bypass grafting, aortic valve replacement, massive air embolism, acute intraoperative aortic dissection, and sudden deterioration in cardiac function. Using deliberate practice, first-year cardiothoracic surgical residents at eight institutions were trained and evaluated on component tasks for each module and later on full cardiac operations. Evaluations were based on five-point Likert-scale tools indexed by module, session, task items, and repetitions. Statistical analyses relied on generalized linear model estimation and corresponding confidence intervals. RESULTS: The 27 residents who participated demonstrated improvement with practice repetitions resulting in excellent final scores per module (mean ± two SEs): cardiopulmonary bypass, 4.80 ± 0.12; coronary artery bypass grafting, 4.41 ± 0.19; aortic valve replacement, 4.51 ± 0.20; massive air embolism, 0.68 ± 0.14; acute intraoperative aortic dissection, 4.52 ± 0.17; and sudden deterioration in cardiac function, 4.76 ± 0.16. The transient detrimental effect of time away from training was also evident. CONCLUSIONS: Overall performance in component tasks and complete cardiac surgical procedures improved during simulation-based training. Simulation-based training imparts skill sets for management of adverse events and can help produce safer surgeons.


Assuntos
Procedimentos Cirúrgicos Cardíacos/educação , Competência Clínica , Simulação por Computador , Educação de Pós-Graduação em Medicina/métodos , Internato e Residência/métodos , Cirurgia Torácica/educação , Humanos
15.
Respir Med ; 100(8): 1402-6, 2006 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-16376535

RESUMO

UNLABELLED: We evaluated an endobronchial valve device in the treatment of surgically created air leak or pneumothorax by eliminating antegrade flow. METHODS: Six sheep underwent general anesthesia with positive pressure ventilation and left thoracotomy. After division of the mediastinal pleura, the contralateral cranial lobe was identified and a 2.5 cmx1.5 cm laceration created with resultant air leak. Using bronchoscopy, we deployed a valve device in the bronchus of the injured segment. Chest drainage tube was placed and the thoracotomy closed. At 1 week (n=3) and 4 weeks (n=3), the animals underwent general anesthesia, bronchoscopy and right thoracotomy. RESULTS: All animals survived the procedure. Bronchoscopic valve device placement in the segmental bronchus resolved the air leak immediately. After closure of thoracotomy, the chest tube demonstrated minimal drainage with no air leak. At 1 and 4 weeks, bronchoscopy showed no change in device location, and the treated segments were atelectatic with fibrous scar at the injured site. CONCLUSIONS: Collapse of a selected lung segment with resolution of air leak can be achieved using bronchoscopically implanted valve device. The valve device may facilitate treatment of patients with post-surgical or post-traumatic persistent air leak.


Assuntos
Fístula Brônquica/cirurgia , Broncoscopia , Pneumotórax/cirurgia , Animais , Próteses e Implantes , Ovinos , Resultado do Tratamento
16.
J Thorac Cardiovasc Surg ; 162(2): 512-513, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-33618880
18.
Semin Thorac Cardiovasc Surg ; 28(1): 1-9, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27568126

RESUMO

Several modern learning frameworks (eg, cognitive apprenticeship, anchored instruction, and situated cognition) posit the utility of nontraditional methods for effective experiential learning. Thus, development of novel educational tools emphasizing the cognitive framework of operative sequences may be of benefit to surgical trainees. We propose the development and global deployment of an effective, mobile cognitive cardiac surgical simulator. In methods, 16 preclinical medical students were assessed. Overall, 4 separate surgical modules (sternotomy, cannulation, decannulation, and sternal closure) were created utilizing the Touch Surgery (London, UK) platform. Modules were made available to download free of charge for use on mobile devices. Usage data were collected over a 6-month period. Educational efficacy of the modules was evaluated by randomizing a cohort of medical students to either module usage or traditional, reading-based self-study, followed by a multiple-choice learning assessment tool. In results, downloads of the simulator achieved global penetrance, with highest usage in the USA, Brazil, Italy, UK, and India. Overall, 5368 unique users conducted a total of 1971 hours of simulation. Evaluation of the medical student cohort revealed significantly higher assessment scores in those randomized to module use versus traditional reading (75% ± 9% vs 61% ± 7%, respectively; P < 0.05). In conclusion, this study represents the first effort to create a mobile, interactive cognitive simulator for cardiac surgery. Simulators of this type may be effective for the training and assessment of surgical students. We investigated whether an interactive, mobile-computing-based cognitive task simulator for cardiac surgery could be developed, deployed, and validated. Our findings suggest that such simulators may be a useful learning tool.


Assuntos
Procedimentos Cirúrgicos Cardíacos/educação , Cognição , Simulação por Computador , Instrução por Computador/métodos , Computadores de Mão , Educação de Graduação em Medicina/métodos , Aplicativos Móveis , Modelos Cardiovasculares , Estudantes de Medicina/psicologia , Adulto , Cateterismo , Gráficos por Computador , Currículo , Avaliação Educacional , Escolaridade , Feminino , Humanos , Masculino , Leitura , Esternotomia/educação , Análise e Desempenho de Tarefas , Técnicas de Fechamento de Ferimentos/educação , Adulto Jovem
19.
Ann Thorac Surg ; 102(4): 1381-6, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27262911

RESUMO

BACKGROUND: The feasibility and efficacy of a web-based curriculum in supplementing thoracic surgical training was previously shown. However, the impact of curricular participation on validated knowledge tests remains unknown. We compared in-service training examination (ITE) results among trainees, stratified by curricular use. METHODS: The national online curriculum was implemented in August 2013. We retrospectively reviewed trainees who participated in thoracic surgical training programs in both 2012 to 2013 and 2013 to 2014. Scores from the 2013 and 2014 ITEs were obtained, and curricular usage data were collected from site analytics. Trainees were separated into three groups according to 2013 ITE scores; within each group, changes in score for high- versus low-volume users were compared. RESULTS: 187 trainees took the ITE both years, with exposure to the online curriculum during only the second year. High-volume users' scores trended toward greater improvement than scores of low-volume users (+18.2% versus +13.0%, p = 0.199). When stratified by 2013 score, the lowest scoring quartile improved substantially, and the highest scoring quartile improved modestly, regardless of curricular use. However, for those individuals who achieved mid-range scores in 2013, there was a trend toward much greater improvement in score with heavier use of the curriculum (+17.0% versus +7.0%, p = 0.094). CONCLUSIONS: Among trainees who had access to the novel online curriculum during the second of 2 consecutive years, we evaluated the impact of curricular participation on ITE scores. The effect appears to be most pronounced in individuals with mid-range scores, in whom high curricular use led to the greatest improvement.


Assuntos
Currículo , Educação de Pós-Graduação em Medicina/métodos , Avaliação Educacional/métodos , Internet , Internato e Residência/métodos , Cirurgia Torácica/educação , Procedimentos Cirúrgicos Torácicos/educação , Competência Clínica , Humanos , Estudos Retrospectivos
20.
Circulation ; 110(8): 988-93, 2004 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-15302782

RESUMO

BACKGROUND: Surgical edge-to-edge repair has been used in the treatment of mitral regurgitation. We evaluated the ability of a catheter-delivered clip (Evalve, Inc) to achieve edge-to-edge mitral valve approximation without cardiopulmonary bypass and the healing response of this technique. METHODS AND RESULTS: Twenty-one pigs underwent general anesthesia and left thoracotomy. A 10F flexible delivery catheter with a clip was placed into the left atrium. With echocardiographic and fluoroscopic guidance, the clip grasped and approximated the mid portion of the anterior and posterior leaflets. After a double orifice had been confirmed, the clip was detached and the catheter withdrawn. All animals survived and had successful clip placement. Three animals were euthanized at 4 weeks, 9 at 12 weeks, 1 at 17 weeks, 7 at 24 weeks, and 1 at 52 weeks. The clip was well positioned, with leaflet approximation in all animals except 1, in which the clip separated from the posterior leaflet at 4 weeks without affecting valve function. The clip was modified and implanted in 4 pigs; all were intact at 12 to 24 weeks. Scanning electron microscopy showed clip encapsulation with complete endothelialization. Mitral stenosis and thromboembolism did not develop. Two animals developed endocarditis (1 at 12 weeks and 1 at 17 weeks). Progressive healing occurred in all other animals. CONCLUSIONS: Edge-to-edge mitral valve approximation can be successfully and reliably achieved with a catheter-delivered clip without cardiopulmonary bypass, resulting in durable healing. The success of this device supports the development of a percutaneous catheter-based system for mitral valve repair.


Assuntos
Cateterismo Cardíaco , Insuficiência da Valva Mitral/cirurgia , Animais , Endocardite Bacteriana/etiologia , Desenho de Equipamento , Fluoroscopia , Hemodinâmica , Procedimentos Cirúrgicos Minimamente Invasivos , Insuficiência da Valva Mitral/diagnóstico por imagem , Insuficiência da Valva Mitral/fisiopatologia , Complicações Pós-Operatórias , Radiografia Intervencionista , Instrumentos Cirúrgicos , Sus scrofa , Ultrassonografia de Intervenção , Cicatrização
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