Awareness of Common Cancer Risk Factors and Symptoms in Saudi Arabia: A Community-Based Study.

OBJECTIVE: To assess the level of cancer awareness and the relationship between the awareness of common cancer symptoms and risk factors and the sample's sociodemographic profile. METHODS: A community-based cross-sectional study conducted in Tabuk city, a convenient sample of 675 participants completed a questionnaire about common factors causing cancer and symptoms related to cancer. Descriptive statistics and chi-squared analysis were used to measure sample characteristics and their association with knowledge of cancer risk factors and symptoms. RESULTS: Level of education and family history were significantly related to awareness of cancer risk factors (P= 0.017) and (P= 0.048), respectively. Factors were significantly associated with awareness of cancer symptoms include Gender (P=0.000), nationality (P=0.013), and undergoing regular cancer screening tests (0.008). Internet was the primary source of information about cancer and related significantly to knowledge about cancer symptoms(P=0.000) and risk factors(P=0.00). More than half of the sample scored poorly for knowledge of both cancer risk factors (58.7%) and symptoms (66.2%) in terms of the overall level of cancer awareness. Smoking and heredity were the most identifiable cancer risk factors, and unexplained pain and weight loss were identified by the majority of study participants. CONCLUSION: The level of community knowledge requires further investigation, and more cancer awareness programs need to be conducted. People could be encouraged to use reliable sources of information to obtain accurate cancer information.
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Serum vitamin D level, sun-exposed area, dietary factors, and physical activity as predictors of invasive breast cancer risk among Sudanese women: A case-control study.

BACKGROUND: The role of vitamin D in the development, progression, and prognosis of breast cancer, though widely studied worldwide, has been inconclusive. This study intended to assess the role of some factors (including serum vitamin D level, sun-exposed area, dietary factors, and physical activity) as predictors of the development of invasive breast cancer (IBC) among Sudanese women. METHODS: A case-control study was conducted on 200 Sudanese women (100 with newly diagnosed IBC and 100 matched healthy females). Serum 25-hydroxyvitamin D was measured through a competitive electrochemiluminescence immunoassay. Matching analysis was adopted by R version 3.4.1 making use of the "MatchIt" package for calculating propensity scores to build a confounder-adjusted, multiple generalized, linear logistic regression model. RESULTS: Participants' age ranged from 28 to 85 years with a mean [±standard deviation (SD)] of 48.10 (±12.11) years. The mean (±SD) serum vitamin D level was 12.97 (±8.60) and 13.79 (±6.79) ng/mL in breast cancer and noncancer Sudanese women, respectively [P = 0.013; odds ratio (OR) 0.862; 95% confidence interval (CI) 0.766-0.969; ß = 0.149)]. Sun-exposed area (P = 0.038; OR 0.013; 95% CI 0.000-0.782; ß = 4.339) is significantly and negatively associated with breast cancer development. While moderate physical activity (P = 0.0008; OR 2625.430; 95% CI 26.647-258673.001; ß = 7.873) is significantly and positively associated with IBC risk. Occasional consumption of milk, dairy products, eggs, and fish reduces the risk of developing IBC by 78.1%, 75.0%, 78.4%, and 76.4%, respectively. CONCLUSION: The higher the plasma vitamin D level by one unit, the lower the risk of breast cancer by 13.84%. Sedentary lifestyle, reduced sun-exposed skin area, and low serum vitamin D levels can be considered as predictors of IBC. Encouraging moderate physical activity and consumption of certain foods may, in part, decrease the precipitating risks of breast cancer. More studies and research are needed to confirm these findings.

Vitamin D level and its determinants among Sudanese Women: Does it matter in a sunshine African Country?

BACKGROUND: Vitamin D deficiency is a worldwide concern. The aim of the current study was to determine the vitamin D level and its contributing factors in Sudanese women. METHODS: In this cross-sectional study, 251 Sudanese women attending Family Health Centers in Khartoum, Sudan were interviewed. Following the exclusion of confounding factors, samples from 190 women were analzsed. Serum 25 hydroxyvitamin D "25(OH) D" was quantified using competitive electrochemiluminescence immunoassay. RESULTS: Participants' age ranged from 18 to 85 years with a mean age (±SD) of 40.2 (±14.06) years. The mean (±SD) vitamin D level was 13.4 (±6.72) ng/ml, ranged 3.00-36.5 ng/ml and the median was 12.7 ng/mL. In total, 157 out of 190 (82.6%) had vitamin D serum levels below 20 ng/ml (deficient); of whom, 52 (27.4%) were in the age group 21-30 years (P value = 0.228). The correlation between vitamin D level and residence outside Khartoum, sun-exposed face and hands, and face and limbs in comparison with being completely covered were found to be statistically significant (p values 0.008, 0.023, and 0.036). CONCLUSION: This study displayed a high percentage (82.6%.) of vitamin D deficiency among women in Sudan, and this in part may indicate that sunshine alone cannot guarantee vitamin D sufficiency in the tropics. Family physicians in tropical countries should screen those with clinical presentations related to vitamin D deficiency.