Detalhe da pesquisa
1.
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Cell
; 176(3): 448-458.e12, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30639101
2.
A rapid, tag-free way to purify functional GPCRs.
J Biol Chem
; 300(1): 105558, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38097184
3.
Styrene-maleic acid copolymer effects on the function of the GPCR rhodopsin in lipid nanoparticles.
Biophys J
; 120(20): 4337-4348, 2021 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34509506
4.
Functional integrity of membrane protein rhodopsin solubilized by styrene-maleic acid copolymer.
Biophys J
; 120(16): 3508-3515, 2021 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34022241
5.
Novel fluorescent GPCR biosensor detects retinal equilibrium binding to opsin and active G protein and arrestin signaling conformations.
J Biol Chem
; 295(51): 17486-17496, 2020 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33453993
6.
Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state.
Proc Natl Acad Sci U S A
; 113(42): 11961-11966, 2016 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27702898
7.
Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs.
Biophys J
; 115(2): 300-312, 2018 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30021106
8.
Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1.
Proc Natl Acad Sci U S A
; 112(27): 8469-74, 2015 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26100912
9.
Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes.
Nat Methods
; 11(9): 931-4, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25086504
10.
Evidence that the Rhodopsin Kinase (GRK1) N-Terminus and the Transducin Gα C-Terminus Interact with the Same "Hydrophobic Patch" on Rhodopsin TM5.
Biochemistry
; 55(22): 3123-35, 2016 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27078130
11.
Conformational selection and equilibrium governs the ability of retinals to bind opsin.
J Biol Chem
; 290(7): 4304-18, 2015 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25451936
12.
Retinal Attachment Instability Is Diversified among Mammalian Melanopsins.
J Biol Chem
; 290(45): 27176-27187, 2015 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26416885
13.
Fluorescence spectroscopy of rhodopsins: insights and approaches.
Biochim Biophys Acta
; 1837(5): 694-709, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24183695
14.
Distance mapping in proteins using fluorescence spectroscopy: tyrosine, like tryptophan, quenches bimane fluorescence in a distance-dependent manner.
Biochemistry
; 53(40): 6290-301, 2014 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25144569
15.
Rhodopsin TM6 can interact with two separate and distinct sites on arrestin: evidence for structural plasticity and multiple docking modes in arrestin-rhodopsin binding.
Biochemistry
; 53(20): 3294-307, 2014 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24724832
16.
A constitutively activating mutation alters the dynamics and energetics of a key conformational change in a ligand-free G protein-coupled receptor.
J Biol Chem
; 288(39): 28207-16, 2013 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23940032
17.
The membrane proximal region of the cannabinoid receptor CB1 N-terminus can allosterically modulate ligand affinity.
Biochemistry
; 52(46): 8286-94, 2013 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24206272
18.
A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569.
J Biol Chem
; 287(40): 33873-82, 2012 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22846992
19.
Rhodopsin in nanodiscs has native membrane-like photointermediates.
Biochemistry
; 50(22): 5086-91, 2011 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21539361
20.
Distance mapping in proteins using fluorescence spectroscopy: the tryptophan-induced quenching (TrIQ) method.
Biochemistry
; 49(45): 9722-31, 2010 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20886836