Detalhe da pesquisa
1.
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens.
Nat Immunol
; 24(2): 320-336, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36717722
2.
A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire.
Mol Cell
; 73(1): 48-60.e5, 2019 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30449725
3.
Enhancers within the Ig V Gene Region Orchestrate Chromatin Topology and Regulate V Gene Rearrangement Frequency to Shape the B Cell Receptor Repertoire Specificities.
J Immunol
; 211(11): 1613-1622, 2023 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37983521
4.
A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation.
Genes Dev
; 29(16): 1683-95, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26302788
5.
CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis.
Proc Natl Acad Sci U S A
; 116(22): 10927-10936, 2019 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31085655
6.
Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny.
Genes Dev
; 27(22): 2439-44, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24240234
7.
Cutting Edge: Proper Orientation of CTCF Sites in Cer Is Required for Normal Jκ-Distal and Jκ-Proximal Vκ Gene Usage.
J Immunol
; 201(6): 1633-1638, 2018 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30076197
8.
YY1 plays an essential role at all stages of B-cell differentiation.
Proc Natl Acad Sci U S A
; 113(27): E3911-20, 2016 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27335461
9.
Targeted chromatin profiling reveals novel enhancers in Ig H and Ig L chain Loci.
J Immunol
; 192(3): 1064-70, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24353267
10.
Unifying model for molecular determinants of the preselection Vß repertoire.
Proc Natl Acad Sci U S A
; 110(34): E3206-15, 2013 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23918392
11.
Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies.
J Immunol
; 191(5): 2393-402, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23898036
12.
Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub.
Proc Natl Acad Sci U S A
; 109(50): E3493-502, 2012 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23169622
13.
Noncoding transcription within the Igh distal V(H) region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells.
Proc Natl Acad Sci U S A
; 109(42): 17004-9, 2012 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23027941
14.
Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus.
J Immunol
; 188(6): 2556-66, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22345664
15.
Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes.
Semin Immunol
; 22(6): 346-52, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20833065
16.
CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells.
Proc Natl Acad Sci U S A
; 108(23): 9566-71, 2011 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21606361
17.
Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression.
Proc Natl Acad Sci U S A
; 107(17): 7869-74, 2010 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-20385820
18.
An Igh distal enhancer modulates antigen receptor diversity by determining locus conformation.
Nat Commun
; 14(1): 1225, 2023 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36869028
19.
The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling.
J Immunol
; 182(3): 1362-9, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19155482
20.
Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development.
J Immunol
; 182(1): 44-8, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19109133