Detalhe da pesquisa
1.
Identification of free fatty acid receptor 2 agonists using virtual screening.
Bioorg Med Chem Lett
; 30(21): 127460, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32755680
2.
Performance of multiple docking and refinement methods in the pose prediction D3R prospective Grand Challenge 2016.
J Comput Aided Mol Des
; 32(1): 113-127, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28913710
3.
Workflows and performances in the ranking prediction of 2016 D3R Grand Challenge 2: lessons learned from a collaborative effort.
J Comput Aided Mol Des
; 32(1): 129-142, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28986733
4.
Mitigation of radiation injury by selective stimulation of the LPA(2) receptor.
Biochim Biophys Acta
; 1831(1): 117-25, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23127512
5.
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
Mol Pharmacol
; 84(3): 415-24, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23793291
6.
Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions.
Mol Pharmacol
; 82(6): 1162-73, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22968304
7.
Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity.
J Med Chem
; 64(8): 4709-4729, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33797924
8.
Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.
J Biol Chem
; 284(25): 17304-17319, 2009 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-19366702
9.
Structure-based drug design identifies novel LPA3 antagonists.
Bioorg Med Chem
; 17(21): 7457-64, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19800804
10.
Molecular recognition in the sphingosine 1-phosphate receptor family.
J Mol Graph Model
; 26(8): 1189-201, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18165127
11.
Identification of non-lipid LPA3 antagonists by virtual screening.
Bioorg Med Chem
; 16(11): 6207-17, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18467108
12.
Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.
J Med Chem
; 60(16): 6771-6780, 2017 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28418656
13.
Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist.
Chem Biol
; 22(2): 206-16, 2015 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25619933
14.
A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor.
BMC Biochem
; 5: 12, 2004 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15298705
15.
Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor.
J Med Chem
; 57(16): 7136-40, 2014 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25100502
16.
Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif.
FEBS J
; 281(4): 1017-28, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24314137
17.
2D binary QSAR modeling of LPA3 receptor antagonism.
J Mol Graph Model
; 28(8): 828-33, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20356772
18.
Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo.
Cancer Res
; 69(13): 5441-9, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19509223
19.
Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors.
J Biol Chem
; 283(18): 12175-87, 2008 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-18316373