RESUMO
A novel tetrahydrofuran derivative, trigonohowine (1), together with five known tetrahydrofuran derivatives (2-6), were isolated from the stems and leaves of Trigonostemon howii. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with the data reported in literature. Among them, trigonohowine (1) represents the first example of a new type of tetrahydrofuran derivative, possessing an unprecedented carbon skeleton containing 23 carbon atoms on the carbon skeleton and the known compouds (2-6) are rare tetrahydrofuran derivatives in the plant kingdom with various carbon skeletons. All isolated compounds were evaluated for their anti-HIV-1 activities. Compounds 1-6 showed significant anti-HIV-1 activities with EC50 ranged from 0.08 to 1.03⯵M. These findings suggest that the discoveries of these tetrahydrofuran derivatives with significant anti-HIV-1 activities isolated from T. howii could be of great importance to the development of new anti-HIV agents.
Assuntos
Fármacos Anti-HIV/farmacologia , Euphorbiaceae/química , Furanos/farmacologia , HIV-1/efeitos dos fármacos , Fármacos Anti-HIV/química , Fármacos Anti-HIV/isolamento & purificação , Linhagem Celular , Furanos/química , Furanos/isolamento & purificação , Humanos , Estrutura Molecular , Folhas de Planta/química , Caules de Planta/químicaRESUMO
Three new dihydrobenzofuran neolignans, mappiodoinins A-C (1-3), together with nine known analogues (4â¯-12) were isolated from the stems and leaves of Mappianthus iodoies. Their structures with the absolute configurations were elucidated by extensive spectroscopic methods. This is the first time to find dihydrobenzofuran neolignans from the genus Mappianthus. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW-480 in vitro. Neolignans 1-12 showed significant cytotoxic effects against various human cancer cell lines with IC50 values ranging from 0.16 to 18.62 µM.
Assuntos
Magnoliopsida/química , Benzofuranos/química , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Lignanas/química , Lignanas/isolamento & purificação , Lignanas/toxicidade , Espectroscopia de Ressonância Magnética , Magnoliopsida/metabolismo , Conformação Molecular , Folhas de Planta/química , Folhas de Planta/metabolismo , Caules de Planta/química , Caules de Planta/metabolismoRESUMO
A new abietane diterpenoid, tripterregeline A (1), together with six known diterpenoids (2-7), were isolated from the roots of Tripterygium regelii. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1-7 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.58 to 21.06 µM.