Detalhe da pesquisa
1.
Aminopyrimidine Derivatives as Multiflavivirus Antiviral Compounds Identified from a Consensus Virtual Screening Approach.
J Chem Inf Model
; 64(2): 393-411, 2024 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38194508
2.
Experimental and Computational Study of Aryl-thiosemicarbazones Inhibiting Cruzain Reveals Reversible Inhibition and a Stepwise Mechanism.
J Chem Inf Model
; 63(5): 1506-1520, 2023 03 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36802548
3.
Discovery and structural optimization of a new series of N-acyl-2-aminobenzothiazole as inhibitors of Zika virus.
Bioorg Med Chem
; 95: 117488, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37812885
4.
Computational approaches towards the discovery and optimisation of cruzain inhibitors.
Mem Inst Oswaldo Cruz
; 117: e210385, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35293427
5.
Antimetastatic effect of the pharmacological inhibition of serine/arginine-rich protein kinases (SRPK) in murine melanoma.
Toxicol Appl Pharmacol
; 356: 214-223, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30138656
6.
Investigation of the binding mode of a novel cruzain inhibitor by docking, molecular dynamics, ab initio and MM/PBSA calculations.
J Comput Aided Mol Des
; 32(5): 591-605, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29564808
7.
Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification.
Bioorg Med Chem
; 25(6): 1889-1900, 2017 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28215783
8.
Corynebacterium pseudotuberculosis may be under anagenesis and biovar Equi forms biovar Ovis: a phylogenic inference from sequence and structural analysis.
BMC Microbiol
; 16: 100, 2016 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27251711
9.
Unraveling the distinctive features of hemorrhagic and non-hemorrhagic snake venom metalloproteinases using molecular simulations.
J Comput Aided Mol Des
; 30(1): 69-83, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26676823
10.
Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.
Antimicrob Agents Chemother
; 59(5): 2666-77, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25712353
11.
Structural design, synthesis and pharmacological evaluation of 4-thiazolidinones against Trypanosoma cruzi.
Bioorg Med Chem
; 23(23): 7478-86, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26549870
12.
Computational drug design strategies applied to the modelling of human immunodeficiency virus-1 reverse transcriptase inhibitors.
Mem Inst Oswaldo Cruz
; 110(7): 847-64, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26560977
13.
Proteome scale comparative modeling for conserved drug and vaccine targets identification in Corynebacterium pseudotuberculosis.
BMC Genomics
; 15 Suppl 7: S3, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25573232
14.
New drug discovery strategies for the treatment of benznidazole-resistance in Trypanosoma cruzi, the causative agent of Chagas disease.
Expert Opin Drug Discov
; 19(6): 741-753, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38715393
15.
New anti-SARS-CoV-2 aminoadamantane compounds as antiviral candidates for the treatment of COVID-19.
Virus Res
; 340: 199291, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38065303
16.
Screening the Pathogen Box to Discover and Characterize New Cruzain and TbrCatL Inhibitors.
Pathogens
; 12(2)2023 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36839523
17.
Structure-based discovery of novel cruzain inhibitors with distinct trypanocidal activity profiles.
Eur J Med Chem
; 257: 115498, 2023 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37290182
18.
Design and synthesis of new 1,2,3-triazoles derived from eugenol and analogues with in vitro and in vivo activity against Trypanosoma cruzi.
Eur J Med Chem
; 258: 115622, 2023 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37441850
19.
Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets.
Expert Opin Ther Targets
; 27(10): 911-925, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37772733
20.
Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice.
Bioorg Med Chem
; 20(21): 6423-33, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23006639