Detalhe da pesquisa
1.
Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.
Bioorg Med Chem Lett
; 90: 129331, 2023 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37187252
2.
Discovery and structure-activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors.
Bioorg Med Chem Lett
; 65: 128648, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35231579
3.
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.
Bioorg Med Chem Lett
; 22(12): 3879-83, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22608965
4.
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition.
Bioorg Med Chem Lett
; 22(17): 5563-8, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22858142
5.
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
J Med Chem
; 55(14): 6363-74, 2012 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22742641
6.
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.
J Med Chem
; 55(20): 8827-37, 2012 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22984809
7.
The benzyne Fischer-indole reaction.
Org Lett
; 13(14): 3667-9, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21671610