Detalhe da pesquisa
1.
The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability.
Liver Int
; 44(3): 760-775, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38217387
2.
Early Increases in Blood Pressure and Major Adverse Cardiovascular Events in Patients With Renal Cell Carcinoma and Thyroid Cancer Treated With VEGFR TKIs.
J Natl Compr Canc Netw
; 21(10): 1039-1049.e10, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37856199
3.
Medical manifestations and health care utilization among adult MyCode participants with neurodevelopmental psychiatric copy number variants.
Genet Med
; 24(3): 703-711, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34906480
4.
Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework.
Drug Metab Dispos
; 50(7): 957-967, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35504655
5.
Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids.
Int J Mol Sci
; 23(3)2022 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35163210
6.
A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids.
Int J Mol Sci
; 23(4)2022 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35216325
7.
Quantitative Systems Toxicology Modeling To Address Key Safety Questions in Drug Development: A Focus of the TransQST Consortium.
Chem Res Toxicol
; 33(1): 7-9, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31909603
8.
The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods.
Arch Toxicol
; 94(7): 2435-2461, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32632539
9.
Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project.
Arch Toxicol
; 93(12): 3643-3667, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31781791
10.
Correction to: Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease.
Proteome Sci
; 16: 13, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29983642
11.
Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease.
Proteome Sci
; 16: 4, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456458
12.
Adverse outcome pathways: opportunities, limitations and open questions.
Arch Toxicol
; 91(11): 3477-3505, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-29051992
13.
QSSPN: dynamic simulation of molecular interaction networks describing gene regulation, signalling and whole-cell metabolism in human cells.
Bioinformatics
; 29(24): 3181-90, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24064420
14.
Protectiveness of NAM-based hazard assessment - which testing scope is required?
ALTEX
; 41(2): 302-319, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38048429
15.
A systems approach reveals species differences in hepatic stress response capacity.
Toxicol Sci
; 196(1): 112-125, 2023 10 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37647630
16.
Probabilistic orthology analysis of the ATP-binding cassette transporters: implications for the development of multiple drug resistance phenotype.
Drug Metab Dispos
; 40(7): 1397-402, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22511348
17.
SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator.
Front Pharmacol
; 13: 929200, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36091744
18.
Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action.
Toxicol In Vitro
; 79: 105269, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-34757180
19.
Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models.
Toxicol In Vitro
; 73: 105133, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33662518
20.
Chemical concentrations in cell culture compartments (C5) - free concentrations.
ALTEX
; 37(4): 693-708, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33080039