[The organizational aspects of early diagnostic of metabolic syndrome on the basis of implementation of new genetic, cellular and bio-informational technologies].

The characteristic feature of molecular medicine as medicine based on molecular structure of human genome data, is its individual character. It is focused on correcting pathological process in specific individual considering unique characteristics of its genome. The other most important feature is its expressed preventive direction. The complete genome information can be obtained well before the onset of disease. The appropriate preventive measures can completely eliminate or significantly prevent development of severe disease. The establishment of gene network of every multi-factorial disease, identification of central genes and genes-modifiers in it, analysis of association of their alleles with disease, development on this basis of set of preventive measures for specific patient constitute conceptual and methodological basis of predictive medicine. As a result of the examination, information can be obtained concerning particular risk of disease development. The physician, considering the results of molecular genetic analysis, elaborates tactics of pathogenetically justified preventive therapy, i.e. corrects congenital metabolic defect.

[Sex- and age-specific characteristics of arterial hypertension prevalence in type 2 diabetes mellitus patients with obesity].

AIM: To investigate sex- and age-specific characteristics of arterial hypertension prevalence in type 2 diabetics with obesity. MATERIAL AND METHODS: Sex- and age-specific features of hypertension prevalence were studied in 6177 (1345 males and 4832 females) type 2 diabetic obese citizens of the Novgorod region. RESULTS: The highest incidence of mild hypertension was found in obesity degrees I and II (50-68%). Prevalence of moderate and severe hypertension reached 20-31 and 4-5%, respectively, in obesity of degree I and II, 15% in males and 11% in females in obesity degree III. CONCLUSION: In type 2 DM obese patients mild hypertension occurs most frequently. Severe hypertension develops often in males with obesity degree II and III in age groups 50-59 and 60-69 years, in females--in any obesity at the age of 70 and older.

[Features of chronic pulmonary diseases in workers engaged in the production of high aluminum mullite refractory items]. / Osobennosti khronicheskikh zabolevanii legkikh u rabochikh na proizvodstve vysokoglinozemistykh mullitovykh ogneupornykh izdelii.

The article represents features for differential diagnosis between pulmonary tuberculosis and dust diseases in workers engaged into mullite refractories production. The author suggests possible course of the disease as a new type of chronic pulmonary malady--mullitosis.

[Fibrogenicity of dust emitted by highly aluminiferous refractories]. / Fibrogennost' pyli vysokoglinozemistykh mullitovykh ogneuporov.

The authors proved variable clinical and pathogenetic features of disease in workers under long occupational exposure to dust of kaolin and its baking products. Therefore, special experimental studies should cover kaolin and mullite as primary and final product in entire technologic sequence of high-alumina refractories production. Natural refractory clay and mullite dust were administered to rats intratracheally during chronic experiments. Lungs of the rats exposed to mullite dust demonstrated reliable changes of lipid content in 1 month and those of hydroxyproline content--in 3 months. When exposed to intratracheal administration of kaolin and mullite dust, respiratory system develops typical changes--slow development of benign diffuse and sclerotic form of pneumoconiosis that is associated or, more frequently, preceded by chronic dust bronchitis.

[Catalytic properties of dust as criteria of its occupational hazards]. / Kataliticheskie svoistva pyli kak kriterii ee professional'noi opasnosti.

The catalytic properties of fire clay (kaolin) and mullet dusts versus quartz, asbestos, and coal ones were studied. Kaolin and mullet were found to have different catalytic capacities mainly of forming free radicals. The dust of kaolin increased the level of superoxide anion radical and hydrogen peroxide in the granulocytic suspension and H2O2/O2 ratio to a lesser extent than that of mullet and quartz. Differences in the catalytic capacity of the examined dusts confirm the findings from the investigations of their effects on plasma lipid peroxidation (LPO). Kaolin and quartz were the least in elevating LPO. As compared with kaolin and quartz, the effects of mullet and asbestos were 2.5 and 6.5 higher, respectively. The substances were different in their genotoxicity.

[Characteristics of work conditions in mullitic refractories production]. / Kharakteristika uslovii truda na proizvodstve mullitovykh ogneupornykh izdelii.

Specific feature of occupational medicine in highly aluminiferous mullitic refractories production nowadays is dust factor associated with disintegration, crushing and pressing of fireclays and coal clays. Therefore average shift dust levels increase and considerably exceed the MAC. Calcination process is associated with slightly exceeded MAC for sulphur dioxide and carbon dioxide and MAL for noise.

[Clinical features of respiratory diseases caused by mullite dust]. / Klinicheskie osobennosti zabolevanii organov dykhaniia pri vozdeistvii mullitovoi pyli.

The authors evaluate clinical peculiarities of chronic bronchitis, silicotuberculosis and pneumoconiosis (mullitosis) in workers exposed to highly aluminiferous clay.

[Aspects of silicotuberculosis course in workers of highly aluminous mullite refractories]. / Osobennosti techeniia silikotuberkuleza u rabochikh na proizvodstve vysokoglinozemistykh mullitovykh ogneupornykh izdelii.

The article covers differential diagnostic features of pulmonary tuberculosis and pneumoconiosis in workers engaged into mullite refractories production. The authors suggest that the disease courses as a new form of lung disorder--mullitosis.