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2.
Diabet Med ; 25(3): 341-8, 2008 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18307461

RESUMO

AIMS: To compare patient-provider differences in diabetes-related perceptions between African-American and White patients and to examine its association with self-care behaviours. METHODS: One hundred and thirty patient-provider pairs were recruited from the greater Detroit area. Patients and providers completed a survey assessing perceptions about diabetes-related concepts and demographic background. The Diabetes Semantic Differential Scale was used to measure diabetes-related perceptions. Patients also reported the frequency of performing self-care behaviours, including following a healthy eating plan, engaging in physical activity, blood glucose monitoring, and taking medication and/or insulin. RESULTS: There were a greater number of patient-provider differences in diabetes-related perceptions for the African-American patients (nine of 18 concepts) compared with the White patients (four of 18 concepts). Stepwise regression analyses found patients' semantic differential scores to be significantly associated with five self-care behaviours for African-American patients and two self-care behaviours for White patients. Providers' semantic differential scores emerged as predictors of self-care behaviours for African-American patients, but not for White patients. CONCLUSIONS: Our findings suggest that compared with White patients, African-Americans differ in a greater number of diabetes-related perceptions than their providers. Patients' and providers' perceptions of diabetes care concepts have a significant impact on a greater number of self-care behaviours for African-American patients than White patients.


Assuntos
Atitude Frente a Saúde , Negro ou Afro-Americano/psicologia , Diabetes Mellitus/psicologia , Autocuidado/psicologia , População Branca/psicologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Diabetes Mellitus/etnologia , Diabetes Mellitus/terapia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estados Unidos
3.
Int J Clin Pract ; 62(6): 860-8, 2008 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18393965

RESUMO

BACKGROUND: Insulin is the most effective drug available to achieve glycaemic goals in patients with type 2 diabetes. Yet, there is reluctance among physicians, specifically primary care physicians (PCPs) in the USA, to initiate insulin therapy in these patients. AIMS: To describe PCPs' attitudes about the initiation of insulin in patients with type 2 diabetes and identify areas in which there is a clear lack of consensus. METHODS: Primary care physicians practicing in the USA, seeing 10 or more patients with type 2 diabetes per week, and having > 3 years of clinical practice were surveyed via an internet site. The survey was developed through literature review, qualitative study and expert panel. RESULTS: Primary care physicians (n = 505, mean age = 46 years, 81% male, 62% with > 10 years practice; 52% internal medicine) showed greatest consensus on attitudes regarding risk/benefits of insulin therapy, positive experiences of patients on insulin and patient fears or concerns about initiating insulin. Clear lack of consensus was seen in attitudes about the metabolic effects of insulin, need for insulin therapy, adequacy of self-monitoring blood glucose, time needed for training and potential for hypoglycaemia in elderly patients. CONCLUSIONS: The beliefs of some PCPs are inconsistent with their diabetes treatment goals (HbA1c < or = 7%). Continuing medical education programmes that focus on increasing primary care physician knowledge about the progression of diabetes, the physiological effects of insulin, and tools for successfully initiating insulin in patients with type 2 diabetes are needed.


Assuntos
Atitude do Pessoal de Saúde , Diabetes Mellitus Tipo 2/tratamento farmacológico , Hipoglicemiantes/uso terapêutico , Insulina/uso terapêutico , Médicos de Família/psicologia , Atenção Primária à Saúde/estatística & dados numéricos , Análise de Variância , Competência Clínica/normas , Competência Clínica/estatística & dados numéricos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Padrões de Prática Médica/estatística & dados numéricos , Inquéritos e Questionários
4.
J Natl Cancer Inst ; 92(11): 924-30, 2000 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-10841828

RESUMO

BACKGROUND: PTEN tumor suppressor gene mutations are the most frequent genetic lesions in endometrial adenocarcinomas of the endometrioid subtype. Testing the hypothesis that altered PTEN function precedes the appearance of endometrial adenocarcinoma has been difficult, however, partly because of uncertainties in precancer diagnosis. METHODS: Two series of endometrial cancer and precancer (endometrial intraepithelial neoplasia, as diagnosed by computerized morphometric analysis) tissue samples were studied, one for PTEN mutations by the use of denaturing gradient gel electrophoresis and another for PTEN protein expression by immunohistochemistry. Endometria altered by high estrogen levels that are unopposed by progestins-conditions known to increase cancer risk-were also studied by immunohistochemistry. Fisher's exact test was used for statistical analysis. RESULTS: The PTEN mutation rate was 83% (25 of 30) in endometrioid endometrial adenocarcinomas and 55% (16 of 29) in precancers, and the difference in number of mutations was statistically significant (two-sided P =.025). No normal endometria showed PTEN mutations. Although most precancers and cancers had a mutation in only one PTEN allele, endometrioid endometrial adenocarcinomas showed complete loss of PTEN protein expression in 61% (20 of 33) of cases, and 97% (32 of 33) showed at least some diminution in expression. Cancers and most precancers exhibited contiguous groups of PTEN-negative glands, while endometria altered by unopposed estrogens showed isolated PTEN-negative glands. CONCLUSIONS: Loss of PTEN function by mutational or other mechanisms is an early event in endometrial tumorigenesis that may occur in response to known endocrine risk factors and offers an informative immunohistochemical biomarker for premalignant disease. Individual PTEN-negative glands in estrogen-exposed endometria are the earliest recognizable stage of endometrial carcinogenesis. Proliferation into dense clusters that form discrete premalignant lesions follows.


Assuntos
Biomarcadores Tumorais/metabolismo , Neoplasias do Endométrio/diagnóstico , Neoplasias do Endométrio/genética , Genes Supressores de Tumor , Mutação em Linhagem Germinativa , Monoéster Fosfórico Hidrolases/genética , Lesões Pré-Cancerosas/diagnóstico , Lesões Pré-Cancerosas/genética , Proteínas Supressoras de Tumor , Análise Mutacional de DNA , Primers do DNA , Diagnóstico Diferencial , Feminino , Regulação Neoplásica da Expressão Gênica , Humanos , Imuno-Histoquímica , PTEN Fosfo-Hidrolase , Reação em Cadeia da Polimerase
5.
Diabetes Care ; 20(3): 244-7, 1997 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-9051365

RESUMO

OBJECTIVE: Many of the "antiseptic" practices recommended by health care professionals for insulin injection have been successfully challenged as unnecessary. Since people with diabetes have long been observed to inject their insulin through their clothing, this study was undertaken to determine the safety and perceived benefits of administering insulin by this "rogue" technique. RESEARCH DESIGN AND METHODS: Fifty people with insulin-treated diabetes were randomized into a 20-week single-blinded prospective crossover study comparing the conventional subcutaneous injection technique (with skin preparation) to an experimental injection technique through clothing. Skin assessment, glycated hemoglobin levels, and leukocyte count were determined before randomization, at 10 weeks (before crossover), and again at 20 weeks (at completion). The participants injected through a single layer of fabric, which ranged from nylon to denim. Problems, benefits, type of clothing, and other comments were recorded by the subjects in an injection log. RESULTS: Forty-two (84%) subjects completed the study. The mean age was 41 years (range, 23-63 years), 50% were women, 86% were Caucasian, and 80% had type I diabetes. The mean duration of diabetes was 14 years (range, 1-33 years). Fifty-one percent had > 16 years of education. The demographic characteristics of the dropouts were similar to those who completed the study. Over the 20-week period approximately 13,720 injections were performed by participants. None of the subjects experienced erythema, induration, or abscess at injection sites. Neither the glycated hemoglobin levels nor the leukocyte counts differed between the conventional and experimental regimens. During the injection-through-clothing phase of the study, only minor problems, such as blood stains on clothing and bruising, were recorded in the logbooks. However, subjects reported that injection through clothing offered benefits such as convenience and saving time. CONCLUSIONS: It is safe and convenient to inject insulin through clothing.


Assuntos
Vestuário , Diabetes Mellitus/tratamento farmacológico , Hipoglicemiantes/administração & dosagem , Insulina/administração & dosagem , Segurança , Adulto , Contagem de Células , Estudos de Coortes , Estudos Cross-Over , Complicações do Diabetes , Diabetes Mellitus/sangue , Feminino , Hemoglobinas Glicadas/análise , Humanos , Injeções Subcutâneas/métodos , Leucócitos/citologia , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Autoadministração , Método Simples-Cego , Fatores de Tempo
6.
Diabetes Care ; 20(3): 299-305, 1997 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-9051376

RESUMO

OBJECTIVE: This study was conducted to compare the Short Form 36 (SF-36) (a global measure of health-related quality of life) and the Diabetes Care Profile (DCP) (a diabetes-specific measure of self-care and diabetes-related quality of life) in patients with NIDDM. RESEARCH DESIGN AND METHODS: This study was conducted as part of a larger study initiated in 1991 using a randomly selected sample of communities, physicians, and patients with diabetes located throughout Michigan. A total of 255 patients with NIDDM participated. The study examined the relationship between the two measures and diabetes variables, such as glycosylated hemoglobin level and number of complications. RESULTS: The SF-36 and the DCP have both common and discrete measurement domains. Both instruments have acceptable subscale reliability. The DCP has predictive validity regarding glycemic control, whereas the SF-36 does not. Both measures correlate with the number of complications for patients who have NIDDM treated with insulin. CONCLUSIONS: This study suggests that for examining relationships within diabetes, e.g., the impact of acute complications and/or regimen on quality of life, the DCP is the appropriate measure. Conversely, when examining relationships between the patient's experience of living with diabetes and quality of life and other chronic diseases, the SF-36 would be an appropriate measure. Both instruments can be used to illuminate the experience and behavior of patients living with and caring for NIDDM.


Assuntos
Diabetes Mellitus Tipo 2 , Qualidade de Vida , Adulto , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/tratamento farmacológico , Feminino , Hemoglobinas Glicadas/análise , Humanos , Hipoglicemiantes/uso terapêutico , Insulina/uso terapêutico , Masculino , Pessoa de Meia-Idade , Análise de Regressão , Autocuidado , Inquéritos e Questionários
7.
Diabetes Care ; 21(9): 1403-7, 1998 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-9727884

RESUMO

OBJECTIVE: The objective of this study was to develop a third version of the Diabetes Attitude Scale (DAS-3) that is congruent with current scientific knowledge about diabetes, has improved subscale internal reliability scores, and is shorter than the earlier versions of this instrument. RESEARCH DESIGN AND METHODS: The second DAS was revised and rewritten by a panel of diabetes experts, including patients, associated with the University of Michigan Diabetes Research and Training Center. The revised version of the instrument was sent to physicians, nurses, dietitians, and patients with diabetes. Completed and usable questionnaires were obtained from 384 patients with diabetes, 321 physicians, 540 nurses, and 569 dietitians. The total number of surveys used for these analyses was 1,814. RESULTS: The study resulted in a revised DAS with 33 items and five discrete subscales. The subscales were attitudes toward the following: 1) need for special training to provide diabetes care, 2) seriousness of type 2 diabetes, 3) value of tight glucose control, 4) pyschosocial impact of diabetes, and 5) attitude toward patient autonomy. Overall, the subscale reliabilities of the DAS-3 were superior to the earlier versions of the scale. CONCLUSIONS: The DAS-3 is a valid and reliable general measure of diabetes-related attitudes and is most suitable for comparisons across different groups of health care professionals and/or patients. The DAS-3 is also suitable for the evaluation of patient and/or professional education programs if those programs focus on the specific topic areas measured by the five DAS-3 subscales.


Assuntos
Atitude do Pessoal de Saúde , Diabetes Mellitus Tipo 2 , Diabetes Mellitus Tipo 2/enfermagem , Diabetes Mellitus Tipo 2/terapia , Educação Médica Continuada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Projetos de Pesquisa
8.
Diabetes Care ; 23(6): 739-43, 2000 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10840988

RESUMO

OBJECTIVE: The purpose of this study was to assess the validity, reliability, and utility of the Diabetes Empowerment Scale (DES), which is a measure of diabetes-related psychosocial self-efficacy. RESEARCH DESIGN AND METHODS: In this study (n = 375), the psychometric properties of the DES were calculated. To establish validity, DES subscales were compared with 2 previously validated subscales of the Diabetes Care Profile (DCP). Factor and item analyses were conducted to develop subscales that were coherent, meaningful, and had an acceptable coefficient alpha. RESULTS: The psychometric analyses resulted in a 28-item DES (alpha = 0.96) with 3 subscales: Managing the Psychosocial Aspects of Diabetes (alpha = 0.93), Assessing Dissatisfaction and Readiness To Change (alpha = 0.81), and Setting and Achieving Diabetes Goals (alpha = 0.91). Consistent correlations in the expected direction between DES subscales and DCP subscales provided evidence of concurrent validity. CONCLUSIONS: This study provides preliminary evidence that the DES is a valid and reliable measure of diabetes-related psychosocial self-efficacy. The DES should be a useful outcome measure for various educational and psychosocial interventions related to diabetes.


Assuntos
Diabetes Mellitus/psicologia , Educação de Pacientes como Assunto , Poder Psicológico , Escalas de Graduação Psiquiátrica , Autoeficácia , Adulto , Idoso , Diabetes Mellitus/reabilitação , Diabetes Mellitus Tipo 1/psicologia , Diabetes Mellitus Tipo 2/psicologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
9.
Diabetes Care ; 23(10): 1511-5, 2000 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-11023145

RESUMO

OBJECTIVE: To examine the relationships among cognitive representations of diabetes, diabetes-specific health behaviors, and quality of life using Leventhal and Diefenbach's self-regulation model of illness (Leventhal H, Diefenbach M: The active side of illness cognition. In Mental Representation in Health and Illness. SkeltonJA, Croyle RT, Eds. New York, Springer-Verlag, 1991, p. 247-272). RESEARCH DESIGN AND METHODS: This research involved secondary analysis of a mailed survey completed by 296 adults (ages 20-90 years). Structural equation modeling was conducted to investigate relationships among cognitive representations, diabetes-specific health behaviors, and quality of life. Model differences by diabetes type were also investigated. RESULTS: Findings indicated that certain cognitive representation constructs were related to increased diabetes-specific health behaviors, decreased sense of burden, and positive quality-of-life outcomes. Individuals levels of understanding of diabetes and their perceptions of control over diabetes were the most significant predictors of outcomes. However, diabetes-specific health behaviors were related to an increased sense of burden that was negatively associated with quality of life. Multigroup analyses indicated that this self-regulatory model provided a good fit for individuals with type 1 diabetes, those with type 2 diabetes who take insulin, and those with type 2 diabetes who do not take insulin. CONCLUSIONS: These findings advance what is known about cognitive representations of illness and the self-regulation of diabetes as well as the relationships between cognitive representations of illness, quality of life, and behavioral factors. In particular, results from this study suggest the need for further study to address ways of reducing the burden of diabetes associated with health behaviors and decreased quality of life.


Assuntos
Cognição , Diabetes Mellitus/psicologia , Diabetes Mellitus/reabilitação , Comportamentos Relacionados com a Saúde , Qualidade de Vida , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Atitude Frente a Saúde , Diabetes Mellitus Tipo 1/psicologia , Diabetes Mellitus Tipo 1/reabilitação , Diabetes Mellitus Tipo 2/psicologia , Diabetes Mellitus Tipo 2/reabilitação , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Insulina/uso terapêutico , Masculino , Pessoa de Meia-Idade , Modelos Psicológicos , Análise de Regressão , Reprodutibilidade dos Testes , Autocuidado , Inquéritos e Questionários
10.
Diabetes Care ; 18(7): 943-9, 1995 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-7555554

RESUMO

OBJECTIVE: The purpose of this study was to determine if participation in a patient empowerment program would result in improved psychosocial self-efficacy and attitudes toward diabetes, as well as a reduction in blood glucose levels. RESEARCH DESIGN AND METHODS: This study was conducted as a randomized, wait-listed control group trial. The intervention group received a six-session (one session per week) patient empowerment education program; the control group was assigned to a wait-list. At the end of 6 weeks, the control group completed the six-session empowerment program. Six weeks after the program, both groups provided follow-up data. RESULTS: The intervention group showed gains over the control group on four of the eight self-efficacy subscales and two of the five diabetes attitude subscales. Also, the intervention group showed a significant reduction in glycated hemoglobin levels. Within groups, analysis of data from all program participants showed sustained improvements in all of the self-efficacy areas and two of the five diabetes attitude subscales and a modest improvement in blood glucose levels. CONCLUSIONS: This study indicated that patient empowerment is an effective approach to developing educational interventions for addressing the psychosocial aspects of living with diabetes. Furthermore, patient empowerment is conducive to improving blood glucose control. In an ideal setting, patient education would address equally blood glucose management and the psychosocial challenges of living with diabetes.


Assuntos
Diabetes Mellitus/psicologia , Diabetes Mellitus/reabilitação , Educação de Pacientes como Assunto , Poder Psicológico , Autocuidado , Ajustamento Social , Adaptação Psicológica , Atitude Frente a Saúde , Glicemia/metabolismo , Diabetes Mellitus/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Tempo , Listas de Espera
11.
Diabetes Care ; 21(5): 706-10, 1998 May.
Artigo em Inglês | MEDLINE | ID: mdl-9589228

RESUMO

OBJECTIVE: To examine the reliability and validity of a brief diabetes knowledge test. The diabetes knowledge test has two components: a 14-item general test and a 9-item insulin-use subscale. RESEARCH DESIGN AND METHODS: Two populations completed the test. In one population, patients received diabetes care in their community from a variety of providers, while the other population received care from local health departments. Cronbach's coefficient alpha was used to calculate scale reliability for each sample. To determine validity, patient group differences were examined. It was hypothesized that test scores would be higher for patients with type 1 diabetes, for patients with more education, and for patients who had received diabetes education. RESULTS: The coefficient alpha s for the general test and the insulin-use subscale indicate that both are reliable, alpha > or = 0.70. In the community sample, patients with type 1 diabetes scored higher than patients with type 2 diabetes on the general test and the insulin-use subscale. In the health department sample, patients with type 1 scored higher than patients with type 2 on the insulin-use subscale. For both samples, scores increased as the years of formal education completed increased, and patients who received diabetes education scored higher than patients who did not. CONCLUSIONS: Although the samples differed demographically, the reliability and validity of the test were supported in both the community and the health department samples. This suggests that the test is appropriate for a variety of settings and patient populations.


Assuntos
Diabetes Mellitus , Avaliação Educacional/normas , Educação de Pacientes como Assunto/normas , Adulto , Idoso , Idoso de 80 Anos ou mais , Interpretação Estatística de Dados , Diabetes Mellitus Tipo 1 , Diabetes Mellitus Tipo 2 , Dieta para Diabéticos , Carboidratos da Dieta , Escolaridade , Feminino , Educação em Saúde/normas , Humanos , Insulina/uso terapêutico , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Inquéritos e Questionários
12.
Diabetes Care ; 23(3): 313-8, 2000 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-10868857

RESUMO

OBJECTIVE: The study examines diabetes attitude differences by treatment modality (insulin vs. no insulin), race/ethnicity, and the interaction of these two variables for people with type 2 diabetes. RESEARCH DESIGN AND METHODS: Data were collected with the Diabetes Care Profile (DCP), an instrument that assesses psychosocial factors related to diabetes. Participants (n = 672) were recruited in the metropolitan Detroit, Michigan, area from 1993 to 1996. A total of 68% of these participants were African-Americans with type 2 diabetes, and 32% were Caucasians with type 2 diabetes. Analyses of covariance were performed to examine the effects of race/ethnicity, treatment, and their interaction for each DCP scale. RESULTS: The four patient categories (two ethnicities by two treatment modalities) differed by age, years with diabetes, education, and sex distribution. Treatment modality had a significant effect on 6 of the 16 DCP scales (Control, Social and Personal Factors, Positive Attitude, Negative Attitude, Self-Care Ability, and Exercise Barriers). Ethnicity was a significant effect for three scales (Control, Support, and Support Attitudes). The interaction of race/ethnicity and treatment modality was a significant effect for two related attitude scales (Positive Attitude and Negative Attitude). CONCLUSIONS: The results suggest that attitudes toward diabetes are similar for African-American and Caucasian patients with type 2 diabetes. The results also suggest that treatment modality has a greater effect on attitudes than either race/ethnicity or the interaction effect. However, Caucasian patients using insulin differed from the other patient groups by having the least positive and the most negative attitudes regarding diabetes.


Assuntos
Atitude Frente a Saúde , Negro ou Afro-Americano/psicologia , Diabetes Mellitus Tipo 2/psicologia , Diabetes Mellitus Tipo 2/terapia , População Branca/psicologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , População Negra , Comparação Transcultural , Diabetes Mellitus Tipo 2/tratamento farmacológico , Exercício Físico , Feminino , Humanos , Insulina/uso terapêutico , Masculino , Michigan , Pessoa de Meia-Idade , Autocuidado , População Urbana
13.
J Clin Endocrinol Metab ; 85(6): 2334-8, 2000 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10852473

RESUMO

Frequent mutation of the PTEN tumor suppressor gene in endometrial adenocarcinoma has led to the prediction that its product, a phosphatase that regulates the cell cycle, apoptosis, and possibly cell adhesion, is functionally active within normal endometrial tissues. We examined PTEN expression in normal human endometrium during response to changing physiological levels of steroid hormones. PTEN ribonucleic acid levels, assessed by RT-PCR, increase severalfold in secretory compared to proliferative endometrium. This suggested that progesterone, a known antineoplastic factor for endometrial adenocarcinoma, increases PTEN levels. Immunohistochemistry with an anti-PTEN monoclonal antibody displayed a complex pattern of coordinate stromal and epithelial expression. Early in the menstrual cycle under the dominant influence of estrogens, the proliferative endometrium shows ubiquitous cytoplasmic and nuclear PTEN expression. After 3-4 days of progesterone exposure, glandular epithelium of early secretory endometrium maintains cytoplasmic PTEN protein in an apical distribution offset by expanding PTEN-free basal secretory vacuoles. By the midsecretory phase, epithelial PTEN is exhausted, but increases dramatically in the cytoplasm of stromal cells undergoing decidual change. We conclude that stromal and epithelial compartments contribute to the hormone-driven changes in endometrial PTEN expression and infer that abnormal hormonal conditions may, in turn, disrupt normal patterns of PTEN expression in this tissue.


Assuntos
Endométrio/metabolismo , Regulação da Expressão Gênica , Genes Supressores de Tumor , Ciclo Menstrual/metabolismo , Monoéster Fosfórico Hidrolases/genética , Proteínas Supressoras de Tumor , Endométrio/patologia , Células Epiteliais/metabolismo , Células Epiteliais/patologia , Feminino , Humanos , Imuno-Histoquímica , PTEN Fosfo-Hidrolase , Monoéster Fosfórico Hidrolases/análise , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Células Estromais/metabolismo , Células Estromais/patologia , Doenças Uterinas/genética , Doenças Uterinas/cirurgia
14.
Am J Clin Pathol ; 113(4): 576-82, 2000 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10787358

RESUMO

Microsatellite instability is a frequent (13%-24%) finding in sporadic endometrial adenocarcinoma and its precursor lesions, but most studies are limited to patients who already have malignant or premalignant endometrial disease. We performed retrospective testing for microsatellite instability in women in whom cancers showing microsatellite instability developed later and prospective testing in randomly selected normal and anovular endometrial biopsy specimens. Microsatellite instability in cancer-bearing biopsy specimens accurately reflected that seen in matched malignant tissues obtained at hysterectomy. In 1 patient, microsatellite instability developed in a scanty sample of fragmented endometrial tissues 7 years before the onset of endometrial cancer. Prospective testing for microsatellite instability in the endometria of women unselected for subsequent appearance of endometrial cancer showed a very low rate of microsatellite instability. Only 1 endometrial specimen showing microsatellite instability was found among 75 anovulatory endometrial specimens, and none were found in 377 normal endometrial specimens and 46 polyps examined. Microsatellite instability may precede the onset of histologically diagnosed carcinoma but is rare in randomly sampled histologically normal endometrial tissues.


Assuntos
Carcinoma Endometrioide/genética , Neoplasias do Endométrio/genética , Endométrio/patologia , Repetições de Microssatélites/genética , Lesões Pré-Cancerosas/genética , Carcinoma Endometrioide/patologia , Carcinoma Endometrioide/cirurgia , Curetagem , Primers do DNA/química , DNA de Neoplasias/análise , Neoplasias do Endométrio/patologia , Neoplasias do Endométrio/cirurgia , Endométrio/efeitos dos fármacos , Estrogênios/efeitos adversos , Feminino , Humanos , Histerectomia , Reação em Cadeia da Polimerase , Lesões Pré-Cancerosas/patologia , Estudos Prospectivos , Estudos Retrospectivos , Sensibilidade e Especificidade
15.
Am J Prev Med ; 13(3): 153-8, 1997.
Artigo em Inglês | MEDLINE | ID: mdl-9181201

RESUMO

OBJECTIVE: Our objective was to evaluate the effectiveness of using simulated patient instructors and the Ockene method to instruct third-year medical students in smoking-cessation counseling techniques. DESIGN: We used a clinical exercise with self-study preparation and simulated patient instructors. METHODS: One hundred fifty-nine students participated in a smoking-cessation counseling session in which cognitive and behavioral endpoints were assessed by simulated patient instructors and the students themselves. RESULTS: Student performance in the cognitive and behavioral components of model smoking-cessation counseling was acceptable. Specific areas of weakness, such as the tendency of students to underemphasize the personal and social benefits of smoking cessation, and to overestimate their competence on a number of skill items, were identified. Student evaluation of the exercise was positive. CONCLUSIONS: Smoking-cessation counseling can be taught effectively to third-year medical students by simulated patient instructors during a clinical clerkship.


Assuntos
Estágio Clínico , Aconselhamento/educação , Simulação de Paciente , Abandono do Hábito de Fumar , Estudos de Avaliação como Assunto , Feminino , Humanos , Masculino , Estudantes de Medicina/psicologia , Ensino/métodos
16.
Acad Med ; 75(7): 737-41, 2000 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10926026

RESUMO

PURPOSE: Accurate self-assessment is an essential skill for the self-directed learning activities and appropriate patient referral decisions of practicing physicians. However, many questions about the characteristics of self-assessment remain unanswered. One is whether self-assessment is a generalizable skill or dependent on the characteristics of the task. This study examines the self-assessment skills of medical students across two task formats: performance-based and cognitive-based. METHOD: In 1997 and 1998, fourth-year medical students at the University of Michigan assessed their own performances on ten stations of a clinical examination. The examination used two formats: performance tasks (the examination or history taking of standardized patients) and cognitive tasks (interpreting vignettes or test results and then answering paper-and-pencil questions). Three measures of self-assessment accuracy were used: a bias index (average difference between the students' estimates of their performances and their actual scores), a deviation index (average absolute difference between estimate and actual score), and an actual score-estimate-of-performance correlation (the correlation between the estimate and actual scores). RESULTS: The student bias and deviation indices were similar on the cognitive and the performance tasks. The correlations also indicated similarity between the two types of tasks. CONCLUSION: The results indicate that the format of the task does not influence students' abilities to self-assess their performances, and that students' self-assessment abilities are consistent over a range of skills and tasks. The authors also emphasize the importance of sampling tasks while conducting self-assessment research.


Assuntos
Autoavaliação (Psicologia) , Programas de Autoavaliação/métodos , Estudantes de Medicina/psicologia , Cognição , Avaliação Educacional , Humanos , Anamnese , Exame Físico , Inquéritos e Questionários
17.
Acad Med ; 75(4): 374-9, 2000 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10893122

RESUMO

PURPOSE: To investigate the impact of self-assessed diagnostic strengths and weaknesses on medical students' allocation of learning time (one indicator of self-directed learning) during a third-year internal medicine clerkship. METHOD: In 1997-98, 107 students at the University of Michigan Medical School self-assessed their diagnostic skills in 14 clinical areas before and after the clerkship and reported the relative amounts of time spent learning about these topics during the clerkship. RESULTS: Individual-level analyses indicated that, for the average student, self-assessed strengths and weaknesses did not correlate with allocation of educational time, but that time allocation was positively related to changes in self-assessed skill. Considerable variations in these relationships, however, suggest a need for closer study. CONCLUSION: Although individual students evidenced different levels of self-directed learning, this study suggests overall that students at this level of training are neophytes in applying both information generated through self-assessment and principles of self-directed learning in their clinical education. Attempts to advance students beyond this level depend on many factors, including the extent to which the learning environment encourages or even permits self-directed learning, the progression and time frame through which students become self-directed practitioners, and the impact of educational interventions to promote this development.


Assuntos
Aprendizagem , Autoavaliação (Psicologia) , Estudantes de Medicina/psicologia , Humanos , Fatores de Tempo
18.
Nutrition ; 9(3): 218-24, 1993.
Artigo em Inglês | MEDLINE | ID: mdl-8353362

RESUMO

Zinc is needed for growth and development, DNA synthesis, neurosensory functions, and cell-mediated immunity. Although zinc intake is reduced in elderly people, its deficiency and effects on cell-mediated immunity of the elderly have not been established. Subjects enrolled in "A Model Health Promotion and Intervention Program for Urban Middle Aged and Elderly Americans" were assessed for nutrition and zinc status. One hundred eighty healthy subjects were randomly selected for the study. Their mean dietary zinc intake was 9.06 mg/day, whereas the recommended dietary allowance is 15 mg/day. Plasma zinc was normal, but zinc in granulocytes and lymphocytes were decreased compared with younger control subjects. Of 118 elderly subjects in whom zinc levels in both granulocytes and lymphocytes were available, 36 had deficient levels. Plasma copper was increased, and interleukin 1 (IL-1) production was significantly decreased. Reduced response to the skin-test antigen panel and decreased taste acuity were observed. Thirteen elderly zinc-deficient subjects were supplemented with zinc, and various variables were assessed before and after zinc supplementation. Zinc supplementation corrected zinc deficiency and normalized plasma copper levels. Serum thymulin activity, IL-1 production, and lymphocyte ecto-5'-nucleotidase increased significantly after supplementation. Improvement in response to skin-test antigens and taste acuity was observed after zinc supplementation. A mild zinc deficiency appears to be a significant clinical problem in free-living elderly people.


Assuntos
Envelhecimento/fisiologia , Zinco/deficiência , 5'-Nucleotidase/efeitos dos fármacos , 5'-Nucleotidase/metabolismo , Idoso , Envelhecimento/imunologia , Cobre/sangue , Deficiências Nutricionais/fisiopatologia , Feminino , Humanos , Sistema Imunitário/efeitos dos fármacos , Sistema Imunitário/fisiologia , Interleucina-1/biossíntese , Masculino , Pessoa de Meia-Idade , Testes Cutâneos , Paladar/efeitos dos fármacos , Fator Tímico Circulante/efeitos dos fármacos , Fator Tímico Circulante/metabolismo , Zinco/metabolismo , Zinco/farmacologia
19.
Acad Radiol ; 3(1): 63-7, 1996 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-8796642

RESUMO

RATIONALE AND OBJECTIVES: We assessed the effects on the perceived quality of faculty teaching of a resident evaluation form that solicits specific comments on faculty strengths and weaknesses. METHODS: An evaluation form was devised that rated faculty on a scale of 1-10 in teaching conference quality, availability, efficiency, and teaching. The form requested constructive comments on faculty strengths and weaknesses. The forms were completed anonymously by residents at all levels. Individual results and means for the department were tabulated and provided to each faculty member in a personal interview. Change in performance was assessed by comparing faculty evaluation scores for 2 consecutive years. RESULTS: The mean faculty scores for teaching conference quality, availability, efficiency, and teaching increased from 7.8, 7.9, 7.9, and 7.7 to 8.1, 8.3, 8.3, and 8.1 in each of the respective areas. The scores of the faculty members who initially received the 10 lowest scores rose to an even greater extent (from 6.2, 6.2, 6.0, and 6.0 to 6.8, 7.4, 7.3, and 6.8 in each of the respective areas), whereas the scores of the faculty members who initially received the 10 highest scores remained relatively constant. CONCLUSION: The perceived quality of certain focused aspects of resident teaching can be modified by use of resident evaluations that solicit specific suggestions for improvement. With appropriate feedback, this is an effective tool for improving the teaching performance of radiology department faculty, particularly those considered to be the weakest teachers.


Assuntos
Internato e Residência , Radiologia/educação , Ensino , Docentes de Medicina , Controle de Formulários e Registros , Humanos
20.
Acad Radiol ; 7(11): 920-6, 2000 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-11089694

RESUMO

RATIONALE AND OBJECTIVES: The authors' purpose was to determine whether there is a relationship between subjective assessment of radiology resident performance on individual rotations and objective assessment of radiology resident performance on the American College of Radiology (ACR) in-training and American Board of Radiology (ABR) written examinations. MATERIALS AND METHODS: Records of 81 radiology residents completing their residency between 1991 and 2000 were reviewed. Mean scores from all rotation evaluation forms obtained during the study period were calculated for each residency year. The means of the overall raw scores and percentiles obtained on the annual ACR in-training examinations during the first 3 years of residency and of the written portion of the ABR examination taken during the 4th year of residency were also determined. Rotation evaluation scores were then compared to examination scores obtained during the same year of residency, and correlation coefficients were obtained. RESULTS: In the 2nd, 3rd, and 4th years of radiology residency, there is positive correlation between rotation evaluation scores and overall scores from the corresponding ACR in-training examination and written portion of the ABR examination taken during the same year. In contrast, in the 1st year of residency, resident rotation evaluation scores do not correlate with ACR in-training examination scores. CONCLUSION: Residents who are perceived as doing well on their rotations after the 1st year of residency are more likely to do well on standardized written examinations.


Assuntos
Avaliação Educacional/métodos , Internato e Residência , Radiologia/educação , Conselhos de Especialidade Profissional , Análise de Variância , Humanos , Sociedades Médicas , Estados Unidos
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