Detalhe da pesquisa
1.
Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules.
Beilstein J Org Chem
; 10: 1848-77, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25246946
2.
Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo.
ACS Chem Neurosci
; 15(6): 1169-1184, 2024 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38359277
3.
NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.
Elife
; 112022 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35234610
4.
Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.
J Med Chem
; 64(6): 2953-2966, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33682420
5.
Total synthesis of (+)-ambruticin S: probing the pharmacophoric subunit.
J Org Chem
; 75(16): 5601-18, 2010 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20704433
6.
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.
J Med Chem
; 62(21): 9618-9641, 2019 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31525968
7.
Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity.
J Med Chem
; 62(2): 908-927, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30499663
8.
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 61(11): 4810-4831, 2018 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29737846
9.
Stereoselective synthesis of pyridinones: application to the synthesis of (-)-barrenazines.
Org Lett
; 8(14): 2985-8, 2006 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16805533
10.
Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.
ACS Med Chem Lett
; 7(3): 277-82, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985315
11.
Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.
Science
; 350(6267): aac5464, 2015 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26680203
12.
Total synthesis of jerangolid A.
Org Lett
; 12(14): 3172-5, 2010 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20565089