Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 44
Filtrar
1.
BMC Pediatr ; 20(1): 505, 2020 11 03.
Artigo em Inglês | MEDLINE | ID: mdl-33143681

RESUMO

BACKGROUND: A child's home and family environment plays a vital role in neuro-cognitive and emotional development. Assessment of a child's home environment and social circumstances is an crucial part of holistic Paediatric assessment. AIMS: Our aim is to achieve full compliance with comprehensive documentation of biopsychosocial history, for all children medically admitted to the children's inpatient unit in University Hospital Limerick. METHODS: We performed a retrospective chart review to audit documentation within our department. This was followed by teaching interventions and a survey on knowledge, attitudes and behaviour of paediatric non-consultant hospital doctors (NCHDs) towards the social history. We performed two subsequent re-audits to assess response to our interventions, and provided educational sessions to seek improvement in quality of care. RESULTS: Results showed a significant improvement in quality of documentation following interventions, demonstrated by a net increase of 53% in levels of documentation of some social history on first re-audit. Though this was not maintained at an optimum level throughout the course of the year with compliance reduced from 95% to 82.5% on second re-audit, there was nonetheless a sustained improvement from our baseline. Our qualitative survey suggested further initiatives and educational tools that may be helpful in supporting the ongoing optimisation of the quality of documentation of social history in our paediatric department. CONCLUSION: We hope this quality improvement initiative will ultimately lead to sustained improvements in the quality of patient-centred care, and early identification and intervention for children at risk in our community.


Assuntos
Documentação , Melhoria de Qualidade , Criança , Hospitalização , Hospitais Pediátricos , Humanos , Estudos Retrospectivos
2.
Neurobiol Aging ; 21(1): 57-62, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-10794849

RESUMO

Midlife hypertension is associated with later development of cognitive impairment, vascular dementia (VsD), and possibly Alzheimer's disease (AD). Neuropathic cerebrovascular lesions and brain atrophy have been associated with elevated blood pressure (BP), however, to our knowledge there have been no prospective investigations of an association of blood pressure levels measured in midlife with the microscopic lesions of AD. We investigated the relationship of BP level in midlife to development of neurofibrillary tangles (NFT), neuritic plaques (NP), and low brain weight at autopsy among Japanese-American men who were members of the Honolulu Heart Program/Honolulu-Asia aging Study (HHP/HAAS) cohort. The HHP/HAAS is a population-based, longitudinal study of cognitive function and dementia with 36 years of follow-up. Neocortical and hippocampal NFT and NP were counted per mm(2), and fixed brain weight was measured for 243 decedents. Elevated systolic BP, (> or =160 mm Hg) in midlife was associated with low brain weight and greater numbers of NP in both neocortex and hippocampus. Diastolic BP elevation, (> or =95 mm Hg) was associated with greater numbers of NFT in hippocampus. Results indicate that in addition to the accepted association of high BP with neuropathic cerebrovascular lesions, there is a direct relationship with brain atrophy, NP and NFT.


Assuntos
Encefalopatias/epidemiologia , Encéfalo/patologia , Hipertensão/epidemiologia , Emaranhados Neurofibrilares/patologia , Placa Amiloide/patologia , Idoso , Idoso de 80 Anos ou mais , Asiático , Povo Asiático , Atrofia/epidemiologia , Atrofia/patologia , Pressão Sanguínea , Encefalopatias/diagnóstico , Encefalopatias/patologia , Estudos de Coortes , Comorbidade , Diástole , Havaí/epidemiologia , Hipocampo/patologia , Humanos , Hipertensão/diagnóstico , Hipertensão/patologia , Estudos Longitudinais , Masculino , Neocórtex/patologia , Tamanho do Órgão , Sístole
3.
Neurology ; 54(6): 1265-72, 2000 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-10746596

RESUMO

OBJECTIVE: To determine whether use of vitamin E and C supplements protects against subsequent development of dementia and poor cognitive functioning. METHODS: The Honolulu-Asia Aging Study is a longitudinal study of Japanese-American men living in Hawaii. Data for this study were obtained from a subsample of the cohort interviewed in 1982, and from the entire cohort from a mailed questionnaire in 1988 and the dementia prevalence survey in 1991 to 1993. The subjects included 3,385 men, age 71 to 93 years, whose use of vitamin E and C supplements had been ascertained previously. Cognitive performance was assessed with the Cognitive Abilities Screening Instrument, and subjects were stratified into four groups: low, low normal, mid normal, and high normal. For the dementia analyses, subjects were divided into five mutually exclusive groups: AD (n = 47), vascular dementia (n = 35), mixed/other types of dementia (n = 50), low cognitive test scorers without diagnosed dementia (n = 254), and cognitively intact (n = 2,999; reference). RESULTS: In a multivariate model controlling for other factors, a significant protective effect was found for vascular dementia in men who had reported taking both vitamin E and C supplements in 1988 (odds ratio [OR], 0.12; 95% CI, 0.02 to 0.88). They were also protected against mixed/other dementia (OR, 0.31; 95% CI, 0.11 to 0.89). No protective effect was found for Alzheimer's dementia (OR, 1.81; 95% CI, 0.91 to 3.62). Among those without dementia, use of either vitamin E or C supplements alone in 1988 was associated significantly with better cognitive test performance at the 1991 to 1993 examination (OR, 1.25; 95% CI, 1.04 to 1.50), and use of both vitamin E and C together had borderline significance (OR, 1.18; 95% CI, 0.995 to 1.39). CONCLUSIONS: These results suggest that vitamin E and C supplements may protect against vascular dementia and may improve cognitive function in late life.


Assuntos
Envelhecimento , Ácido Ascórbico/uso terapêutico , Cognição/efeitos dos fármacos , Demência/tratamento farmacológico , Demência/psicologia , Vitamina E/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Humanos , Masculino , Razão de Chances , Escalas de Graduação Psiquiátrica , Fatores de Tempo
4.
Neurology ; 54(7): 1526-9, 2000 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-10751272

RESUMO

The authors assessed the 3-year incidence of dementia, including subtypes, in 2,603 Japanese-American men 71 to 93 years of age who were dementia free at baseline. There were 137 new cases of dementia according to the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised, including 51 with a primary diagnosis of AD. The rates for all subtypes increased with age. Men with an APOE4 allele had a significantly increased risk of AD of 2.39 (95% CI, 1.07, 5.31), after adjusting for age and education. There was no significant relationship of APOE4 with other subtypes of dementia.


Assuntos
Doença de Alzheimer/epidemiologia , Doença de Alzheimer/genética , Apolipoproteínas E/genética , Povo Asiático/genética , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Envelhecimento/etnologia , Envelhecimento/genética , Alelos , Doença de Alzheimer/classificação , Apolipoproteína E4 , Asiático , Estudos de Coortes , Humanos , Incidência , Japão/etnologia , Masculino , Testes Neuropsicológicos , Risco
5.
Neurology ; 53(2): 337-43, 1999 Jul 22.
Artigo em Inglês | MEDLINE | ID: mdl-10430423

RESUMO

BACKGROUND: The Honolulu Heart Program (HHP) is a prospective study of heart disease and stroke that has accumulated risk factor data on a cohort of 8,006 Japanese American men since the study began in 1965. A recent examination of the cohort identified all patients with vascular dementia (VaD) using the criteria of the California Alzheimer's Disease Diagnostic and Treatment Center. OBJECTIVE: To characterize patients with VaD by stroke subtype and to investigate risk factors for VaD in a cohort of Japanese American men, aged 71 to 93, living in Hawaii and participating in the HHP. METHODS: Sixty-eight men with VaD were compared with 3,335 men without dementia or stroke (NSND). Men with VaD were also compared with 106 men with stroke who were not demented (SND). Candidate risk factors were measured prospectively. RESULTS: Of the 68 men with VaD there were 34 (50%) whose VaD was attributed to small vessel infarcts, 16 (23%) whose VaD was related to large vessel infarcts, and 11 (16%) with both large and small vessel infarcts. The remainder could not be classified. In a multivariate logistic regression model for VaD compared with NSND containing variables found to be associated with VaD in a univariate analysis, age (odds ratio [OR] 1.19, 95% confidence interval [CI] 1.13 to 1.27), coronary heart disease (OR 2.50, 95% CI 1.35 to 4.62), and 1-hour postprandial glucose (OR 1.41, 95% CI 1.06 to 1.88) remained significantly predictive of VaD, whereas preference for a Western diet (OR 0.54, 95% CI 0.30 to 0.98) as opposed to an Oriental or mixed diet and use of supplementary vitamin E (OR 0.32, 95% CI 0.12 to 0.82) were protective. A similar model for the comparison of men with VaD and SND revealed age (OR 1.24, 95% CI 1.14 to 1.35) was predictive of VaD, whereas preference for a Western diet (OR 0.43, 95% CI 0.22 to 0.86) was protective. CONCLUSIONS: The most common stroke subtype associated with VaD was lacunar stroke. Age and traditional vascular risk factors are important contributors to the development of VaD in late life. The antioxidant vitamin E and presently unknown factors related to a Western diet as opposed to an Oriental diet may be protective against developing VaD.


Assuntos
Transtornos Cerebrovasculares/epidemiologia , Demência Vascular/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Ásia , Havaí , Humanos , Masculino , Razão de Chances , Estudos Prospectivos , Fatores de Risco
6.
Br J Pharmacol ; 48(3): 418-25, 1973 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-4764290

RESUMO

1. Daily i.p. administration, for eight days, of the cholinesterase inhibitor disulfoton to rats produced mild to moderate signs of intoxication (tremors, incontinence and diarrhoea) but no deaths.2. Segments of ileum taken from the treated rats were subsensitive to carbachol but the vas deferens and the uterus did not exhibit any change in sensitivity to carbachol.3. The sensitivity to acetylcholine was increased in the ileum and vas deferens but not in the uterus.4. Acetylcholinesterase activity was 60-70% inhibited in all three tissues.


Assuntos
Acetilcolina/farmacologia , Carbacol/farmacologia , Inseticidas/farmacologia , Músculo Liso/efeitos dos fármacos , Animais , Colinesterases/análise , Diarreia/induzido quimicamente , Dissulfóton/farmacologia , Interações Medicamentosas , Feminino , Íleo/efeitos dos fármacos , Técnicas In Vitro , Masculino , Pré-Medicação , Ratos , Tremor/induzido quimicamente , Incontinência Urinária/induzido quimicamente , Útero/efeitos dos fármacos , Ducto Deferente/efeitos dos fármacos
7.
Sleep ; 22 Suppl 2: S366-72, 1999 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-10394609

RESUMO

To determine incidence and remission rates of insomnia in older adults and associated risk factors. Three-year longitudinal study, 1982-198--East Boston, MA; New Haven, CT; Iowa and Washington counties, IA. Participants were 6,899 men and women aged 65 years and older. Self-reported difficulty falling asleep or early morning arousal (insomnia), along with physician diagnosis of heart disease, stroke, cancer, diabetes, or hip-fracture, self-report of physical disability, depressive symptomatology, perceived health status, and use of medications ascertained at both baseline and three-year follow-up. Nearly 15% of the 4,956 participants without symptoms of insomnia at baseline reported chronic difficulty falling asleep or early morning arousal at follow-up, suggesting an annual incidence rate of approximately 5%. Incident insomnia was associated with depressed mood, respiratory symptoms, fair to poor perceived health, and physical disability. In multivariate analyses, these risk factors explained the higher incidence of insomnia among those with medical conditions such as heart disease, stroke, and diabetes. Other factors associated with an increased risk of insomnia included use of prescribed sedatives, and widowhood. Only 7% of the incident cases of insomnia occurred in the absence of associated risk factors. Of the nearly 2,000 survivors with chronic insomnia at baseline, almost half no longer reported symptoms upon follow-up and were more likely to report improved self-perceived health compared to those who continued to report symptoms. Chronic disease, depressed mood, physical disability, poor perceived health, widowhood, and use of sedatives are associated with development and remission of insomnia symptoms. Because the vast majority of incident cases of insomnia were among persons with one or more of these risk factors, these data do not support a model of incident insomnia caused by the aging process per se.


Assuntos
Distúrbios do Início e da Manutenção do Sono/diagnóstico , Distúrbios do Início e da Manutenção do Sono/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Envelhecimento/fisiologia , Doença Crônica , Feminino , Seguimentos , Humanos , Incidência , Masculino , Massachusetts/epidemiologia , Prevalência , Estudos Retrospectivos , Inquéritos e Questionários , Fatores de Tempo
8.
Sleep ; 22 Suppl 2: S373-8, 1999 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-10394610

RESUMO

OBJECTIVES: To determine the incidence and remission rates of insomnia in older adults according to race and associated risk factors in a three-year longitudinal study. METHODS: 2,971 men and women, aged 65 years and older, completed questionnaires administered by trained interviewers at baseline and three years later. Data concerning difficulty falling asleep or early morning arousal (insomnia), along with self-reports of physical disability, respiratory symptoms, depressive symptomatology, perceived health status, and use of prescribed sedative medication, were collected and analyzed. RESULTS: Overall, 15% of the participants without symptoms of insomnia at baseline reported chronic difficulty falling asleep or early morning arousal three years later in follow-up interviews. African-American women had a significantly (p < 0.01) higher incidence of insomnia (19%) compared with African-American men (12%) or with white men and women (both 14%). Men were more likely than women to no longer report symptoms at follow-up (64% vs 42%; p < 0.01). For both races, the presence of depressed mood was a risk factor for the incidence of insomnia, and the absence of depressed mood was a predictor of remission. CONCLUSIONS: Insomnia occurs more frequently in African-American women than in African-American men or than in white men or women. Regardless of race, women are less likely than men to resolve their insomnia. The high prevalence and incidence of morbidity in elderly African-American women may contribute to their high rate of insomnia.


Assuntos
Distúrbios do Início e da Manutenção do Sono/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Depressão/etiologia , Feminino , Seguimentos , Nível de Saúde , Humanos , Incidência , Masculino , North Carolina/epidemiologia , Grupos Raciais , Remissão Espontânea , População Rural/estatística & dados numéricos , Distribuição por Sexo , Distúrbios do Início e da Manutenção do Sono/diagnóstico , Distúrbios do Início e da Manutenção do Sono/psicologia , Inquéritos e Questionários , População Urbana/estatística & dados numéricos
9.
Sleep ; 18(6): 425-32, 1995 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-7481413

RESUMO

The frequencies of five common sleep complaints--trouble falling asleep, waking up, awaking too early, needing to nap and not feeling rested--were assessed in over 9,000 participants aged 65 years and older in the National Institute on Aging's multicentered study entitled "Established Populations for Epidemiologic Studies of the Elderly" (EPESE). Less than 20% of the participants in each community rarely or never had any complaints, whereas over half reported at least one of these complaints as occurring most of the time. Between 23% and 34% had symptoms of insomnia, and between 7% and 15% percent rarely or never felt rested after waking up in the morning. In multivariate analyses, sleep complaints were associated with an increasing number of respiratory symptoms, physical disabilities, nonprescription medications, depressive symptoms and poorer self-perceived health. Sleep disturbances, particularly among older persons, oftentimes may be secondary to coexisting diseases. Determining the prevalence of specific sleep disorders, independent of health status, will require the development of more sophisticated and objective measures of sleep disturbances.


Assuntos
Distúrbios do Início e da Manutenção do Sono/epidemiologia , Fatores Etários , Idoso , Estudos de Coortes , Feminino , Nível de Saúde , Humanos , Masculino , Prevalência , Fatores Sexuais , Inquéritos e Questionários , Estados Unidos/epidemiologia
10.
Int J Epidemiol ; 20 Suppl 1: S8-17, 1991.
Artigo em Inglês | MEDLINE | ID: mdl-9119546

RESUMO

Older people often have several co-existing health problems. The type, number, duration and severity of these problems may have an impact on longevity and maintenance of independence. Analyses of co-morbidity can assess the additive or multiplicative effect of more than one chronic condition or impairment on the risks of mortality, loss of functioning and use of health services. Three major surveys of the elderly, initiated in the past ten years, provide data for studying the added burden of multiple morbidities. These surveys are: The National Health Interview Survey-Supplement on Aging; The National Health and Nutrition Examination Survey I-Epidemiologic Follow-up Study; and The Established Populations for Epidemiologic Studies of the Elderly. Results of analyses of co-morbidity using data from these three surveys are presented. Although each analysis used a different definitional approach to estimate the co-morbidity effect, each demonstrated an associated or increased risk on the outcome.


Assuntos
Comorbidade , Idoso Fragilizado/estatística & dados numéricos , Instalações de Saúde/estatística & dados numéricos , Nível de Saúde , Mortalidade , Atividades Cotidianas , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Métodos Epidemiológicos , Feminino , Inquéritos Epidemiológicos , Humanos , Masculino , Prevalência , Estados Unidos/epidemiologia
11.
J Am Geriatr Soc ; 43(7): 776-81, 1995 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-7602030

RESUMO

OBJECTIVE: To estimate the motor vehicle crash rate in a cohort of older drivers from a rural community and to identify health-related conditions that increase their risk for crash involvement. DESIGN: Cohort study with 5 years of crash-record surveillance. SETTING: The Iowa 65+ Rural Health Study, one of four Established Populations for Epidemiologic Studies of the Elderly (EPESE). PARTICIPANTS: A total of 1791 drivers aged 68 years and older. MAIN MEASURES: Exposure measures of physical, mental, and sensory well-being from a health interview survey; outcome measure of police-reported crashes maintained by the Iowa Department of Motor Vehicles. RESULTS: Between 1985 and 1989, 206 drivers were involved in 245 state-recorded crashes. The estimated annual crash involvement rate for these rural older drivers (28 per 1000 driving-years) was about 20% less than the national average for drivers aged 65 years and over (36 per 1,000). An increased risk for motor vehicle crashes was associated with episodes of back pain (Relative Risk = 1.4, P < .05), use of nonsteroidal anti-inflammatory drugs (RR = 1.7, P < .01), and poor performance on a free-recall memory test (RR = 1.4, P < .05). CONCLUSIONS: If these and other geriatric conditions are confirmed as risk factors for motor vehicle crashes, medical guidelines for license renewal may need updating and health professionals may need new instruments to detect older patients at high risk for unsafe driving.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Saúde da População Rural , Distribuição por Idade , Idoso , Feminino , Avaliação Geriátrica , Nível de Saúde , Humanos , Iowa/epidemiologia , Masculino , Vigilância da População , Modelos de Riscos Proporcionais , Estudos Prospectivos , Fatores de Risco , Distribuição por Sexo
12.
J Am Geriatr Soc ; 49(9): 1185-9, 2001 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11559377

RESUMO

OBJECTIVES: To examine whether self-reported symptoms of insomnia independently increase risk of cognitive decline in older adults. DESIGN: Longitudinal cohort study. SETTING: The four sites of the Established Populations for Epidemiologic Studies of the Elderly. PARTICIPANTS: Six thousand four hundred forty-four community-dwelling men and women age 65 and older who had no more than one error on the Short Portable Mental Status Questionnaire (SPMSQ) at baseline and an in-person interview at the third annual follow-up (FU3). MEASUREMENTS: Insomnia was defined as report of trouble falling asleep or waking up too early most of the time. Cognitive decline was defined as two or more errors on the SPMSQ at FU3. Logistic regression was used to determine risk of cognitive decline associated with insomnia, controlling for demographic, behavioral, and health-related factors. Analyses were stratified by sex and depressed mood. RESULTS: Among nondepressed men, those reporting symptoms of insomnia at both baseline and FU3 had an adjusted odds ratio (OR) of 1.49 (95% CI = 1.03-2.14) for cognitive decline, relative to those with no insomnia at FU3. Men with insomnia at FU3 only were not at increased risk (OR = 1.16, 95% CI = 0.82-1.65). These relationships were not found in women. Men and women with depressive symptoms at FU3 were at increased risk for cognitive decline independent of insomnia. CONCLUSION: Chronic insomnia independently predicts incident cognitive decline in older men. More sensitive measures of cognitive performance may identify more subtle declines and may confirm whether insomnia is associated with cognitive decline in women.


Assuntos
Transtornos Cognitivos/epidemiologia , Distúrbios do Início e da Manutenção do Sono/complicações , Fatores Etários , Idoso , Depressão/epidemiologia , Feminino , Humanos , Incidência , Modelos Logísticos , Estudos Longitudinais , Masculino , Análise Multivariada , Razão de Chances , Prevalência , Risco , Fatores Sexuais , Estados Unidos/epidemiologia
13.
J Am Geriatr Soc ; 44(6): 693-8, 1996 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-8642162

RESUMO

OBJECTIVE: To describe the demographic and health-related factors related to excessive daytime sleepiness. To estimate the risk of mortality associated with excessive daytime sleepiness independent of nightime sleep problems and other factors that limit survival. DESIGN: Four-year prospective cohort study with annual interviews. SETTING: One urban and four rural counties in north-central North Carolina. PARTICIPANTS: Adults 65 years and older (n = 3962) living in the community. MAIN OUTCOME MEASURES: Excessive daytime sleepiness was measured as, "How often do you get so sleepy during the day or evening that you have to take a nap?" Mortality was based on continuous surveillance of the population by field investigators and abstraction of death certificates. RESULTS: Point prevalence of excessive daytime sleepiness in this population was 25.2%. Frequent daytime nappers were more likely than infrequent nappers to report nighttime sleep complaints and were more likely to be male and urban-dwellers, to report more depressive symptoms, more limited physical activity, and more functional impairment, and were more likely to be overweight. Of the frequent nappers, 23.9% died, compared with 15.4% of infrequent nappers. In an adjusted Cox proportional hazard model, the 4-year mortality rate was accelerated 1.73 times among older people who nap most of the time and make two or more errors on a cognitive status examination. CONCLUSION: Excessive napping is associated with impaired sleep hygiene as well as with a broad range of activity-related health deficits among community-dwelling older adults. Frequent napping was associated with impaired sleep hygiene, male gender, urban-dwelling, depressive symptoms, physical activity deficits, functional impairment, and excess weight. Mortality risk was elevated selectively among the most cognitively impaired subjects.


Assuntos
Ritmo Circadiano , Distúrbios do Sono por Sonolência Excessiva/etiologia , Distúrbios do Sono por Sonolência Excessiva/mortalidade , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , North Carolina/epidemiologia , Prevalência , Modelos de Riscos Proporcionais , Estudos Prospectivos , Fatores de Risco , Saúde da População Rural , Análise de Sobrevida , Saúde da População Urbana
14.
J Am Geriatr Soc ; 48(8): 928-30, 2000 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-10968296

RESUMO

OBJECTIVE: To determine the prevalence and cessation of driving among older men with incident dementia in the Honolulu-Asia Aging Study. DESIGN: Retrospective cohort data from a community-based study of incident dementia. SETTING: The Honolulu Heart Program and the Honolulu-Asia Aging Study. PARTICIPANTS: A total of 643 men who were evaluated for the incidence of Alzheimer's disease or other dementia between the fourth and the fifth examination of the Honolulu Heart Program. MEASUREMENTS: Driving history, diagnosis of dementia, grip strength, walking speed, standing balance test, interviewer's rating of vision status, and the neurologist's notes on mentions of driving behavior from informal interviews with a caregiver or family informant. RESULTS: The prevalence of driving declined dramatically with level of cognitive functioning. Among 162 men evaluated and found to have normal cognitive functioning, 78% still drove, compared with 62% of 287 men with poor cognitive functioning but no clinical dementia, 46% of 96 men with a new diagnosis of very mild dementia (Clinical Dementia Rating = 0.5), and 22% of 98 men with a new diagnosis of mild dementia (CDR = 1). Only one of 23 men diagnosed with moderate or more severe staged incident dementia (CDR > 1) was driving. About 10% of the 59 demented persons still driving relied on co-pilots, and only one driver was reported as involved in a crash according to a review of the neurologists' notes. CONCLUSIONS: Incident dementia is a major cause of driving cessation. Based on these data, we estimate that approximately 4% of male drivers aged 75 years and older nationwide (about 175,000 men) have dementia. This number will increase with the projected growth of drivers aged 75 years and older.


Assuntos
Condução de Veículo/estatística & dados numéricos , Demência/epidemiologia , Atividades Cotidianas , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Condução de Veículo/psicologia , Cognição , Demência/diagnóstico , Demência/psicologia , Avaliação Geriátrica , Força da Mão , Havaí/epidemiologia , Humanos , Incidência , Modelos Logísticos , Masculino , Programas de Rastreamento , Prevalência , Estudos Retrospectivos , Inquéritos e Questionários , Caminhada
15.
J Am Geriatr Soc ; 43(11): 1191-7, 1995 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-7594151

RESUMO

OBJECTIVE: To determine whether older persons with hypertension who use specific calcium antagonists and ACE inhibitors have a different risk of mortality than those using beta-blockers. DESIGN: A prospective cohort study continuing from 1988 through 1992. SETTING: Three communities of the Established Populations for Epidemiologic Studies of the Elderly. PARTICIPANTS: Hypertensive participants aged > or = 71 years (n = 906) who had no evidence of congestive heart failure and who were using either beta-blockers (n = 515), verapamil (n = 77), diltiazem (n = 92), nifedipine (n = 74), or ACE inhibitors (n = 148). Nifedipine was of the short acting variety. MEASUREMENTS: The main outcome measure was all-cause mortality. Age, gender, smoking, HDL-cholesterol, blood pressure, intake of digoxin and diuretics, physical disability, self-perceived health, and comorbid conditions were examined as confounders. RESULTS: During 3538 person-years of follow-up, 188 participants died (53 deaths per 1000 person-years). Compared with beta-blockers, after adjusting for age, gender, comorbid conditions and other health-related factors, the relative risks (95% confidence interval) for mortality associated with use of verapamil, diltiazem, nifedipine, and ACE inhibitors were 0.8 (0.4-1.4), 1.3 (0.8-2.1), 1.7 (1.1-2.7), and 0.9 (0.6-1.4), respectively. The results were unchanged after excluding participants with other potential contraindications to beta-blockers and after stratifying on coronary heart disease and use of diuretics. Higher doses of nifedipine were associated with higher mortality. CONCLUSION: Compared with beta-blockers, use of short acting nifedipine was associated with decreased survival in older hypertensive persons. However, selective factors influencing the use of specific drugs in higher risk patients could not be completely discounted, and final conclusions will depend on clinical trials.


Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Bloqueadores dos Canais de Cálcio/uso terapêutico , Hipertensão/tratamento farmacológico , Isquemia Miocárdica/mortalidade , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Feminino , Insuficiência Cardíaca/mortalidade , Humanos , Hipertensão/mortalidade , Estudos Longitudinais , Masculino , Modelos de Riscos Proporcionais , Fatores de Risco , Fatores Sexuais , Taxa de Sobrevida
16.
J Am Geriatr Soc ; 46(2): 161-8, 1998 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-9475443

RESUMO

OBJECTIVES: To determine the prevalence rates of self-reported sleep complaints and their association with health-related factors. DESIGN: A cross-sectional study. SETTING: People living in the community. PARTICIPANTS: A total of 2398 noninstitutionalized individuals, aged 65 years and older, residing in the Veneto region, northeast Italy. MEASUREMENTS: Odds ratios for the association of sleep complaints with potential risk factors. RESULTS: The prevalence of insomnia was 36% in men and 54% in women, with increased risks for women (odds ratio (OR) = 1.69, 95% CI: 1.3-2.1), depression (OR = 1.93, 95% CI, 1.5-2.5), and regular users of sleep medications (OR = 5.58, 95% CI, 4.3-7.3). About 26% of men and 21% of women reported no sleep complaints. Night awakening, reported by about two-thirds of the participants, was the most common sleep disturbance. Women and regular users of sleep medications had significantly increased odds for insomnia and for not feeling rested upon awakening in the morning. Depressive symptomatology was more strongly associated with insomnia and night awakening than with awakening not rested, whereas physical disability was more strongly associated with awakening not rested than with the other two sleep disturbances. CONCLUSION: Our findings show that sleep complaints, highly common among older Italians, are associated with a wide range of medical conditions and with the use of sleep medications. Further longitudinal studies are needed to investigate the causes and the negative health consequences of sleep disturbances to improve both the diagnosis and treatment.


Assuntos
Transtornos do Sono-Vigília/epidemiologia , Idoso , Estudos Transversais , Depressão/complicações , Feminino , Comportamentos Relacionados com a Saúde , Humanos , Hipnóticos e Sedativos/uso terapêutico , Itália/epidemiologia , Masculino , Prevalência , Distúrbios do Início e da Manutenção do Sono/complicações , Distúrbios do Início e da Manutenção do Sono/epidemiologia , Transtornos do Sono-Vigília/complicações , Transtornos do Sono-Vigília/etiologia , Fatores Socioeconômicos
17.
J Am Geriatr Soc ; 43(8): 860-4, 1995 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-7636092

RESUMO

OBJECTIVE: To evaluate the impact of caffeine in medication on sleep complaints in a community population of persons aged 67 or older. DESIGN: Cross-sectional analysis. SETTING: Iowa 65+ Rural Health Study. PARTICIPANTS: Those who completed their own interview, including a section on the use of medications, during the third annual in-person follow-up in 1984-1985. MAIN OUTCOMES: trouble falling asleep or other sleep complaints. Covariates: use of caffeine-containing medication, spasmolytic, or sympathomimetic drug; number of drugs used; depressive symptoms; self-perceived health; comorbidity, hip fracture, arthritis, ulcer of stomach or intestines; and consumption of caffeinated beverages. RESULTS: The prevalence of caffeinated medication use by participants was 5.4%. Those reporting the use of any caffeine-containing medication were at an increased risk of having trouble falling asleep (Odds Ratio [OR] = 1.79, 95% confidence interval [CI] = 1.19-2.68). There was no significant risk of other reported nighttime or daytime sleep problems associated with use of caffeine-containing drugs. Even after adjusting for other factors that could interfere with initiation of sleep, such as painful disease, depressive symptoms, polypharmacy, use of specific medications known to interfere with sleep, and coffee consumption, the use of caffeine-containing medication still presented a significantly increased risk of having trouble falling asleep (OR = 1.60, CI = 1.04-2.46). Although those participants using over-the-counter analgesic medication containing caffeine had an increased risk of trouble falling asleep (OR = 1.88, CI = 1.22-2.90), there was no significant risk of trouble falling asleep for those who took similar noncaffeinated OTC analgesic drugs (OR = 1.26, CI = 0.87-1.83). CONCLUSIONS: The use of caffeine-containing medication is associated with sleep problems. Healthcare providers should be aware of potential problems associated with over-the-counter medications containing caffeine and should counsel patients about the potential of sleep problems. Older patients should be encouraged to read the label on medications and to select drugs that are caffeine-free when that is possible.


Assuntos
Cafeína/efeitos adversos , Transtornos do Sono-Vigília/induzido quimicamente , Idoso , Estudos Transversais , Inquéritos sobre Dietas , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Feminino , Seguimentos , Humanos , Iowa/epidemiologia , Modelos Logísticos , Masculino , Saúde da População Rural , Transtornos do Sono-Vigília/epidemiologia , Inquéritos e Questionários
18.
J Am Geriatr Soc ; 47(5): 524-8, 1999 May.
Artigo em Inglês | MEDLINE | ID: mdl-10323643

RESUMO

OBJECTIVES: To examine the association between symptoms of sleep apnea and prevalent cardiovascular disease, cognitive impairment, and subsequent 3-year mortality. DESIGN: A longitudinal study. SETTING: Participants lived in the community on Oahu, Hawaii. PARTICIPANTS: A total of 2905 older Japanese-American men participating in the fourth examination of the Honolulu Heart Program cohort study from 1991-1993, which is the baseline for the Honolulu-Asia Aging Study of dementia. MEASUREMENTS: Self-reported snoring, daytime sleepiness, and breathing pauses; diagnosed cardiovascular disease and dementia; cognitive functioning and vital status approximately 3 years later. RESULTS: More than 12% of the participants reported that they often or always snored loudly, and 8% reported being sleepy most of the day. Fewer than 2% reported that they stop breathing when sleeping, and this was found more frequently among habitual snorers (7%, P < .001) and those sleepy during the day (5%, P < .001). The prevalence of habitual snoring declined in the older age groups, was higher among those with greater Body Mass Index scores, and was not associated with the reporting of daytime sleepiness, diagnosis of heart disease, stroke, dementia, or cognitive impairment. Daytime sleepiness was more prevalent at older ages and was associated with a higher prevalence of heart disease and with cognitive impairment and dementia, chronic obstructive pulmonary disease, and diabetes. Self-reported apnea was associated only with a history of pneumonia. Three-year mortality was not associated with these symptoms after adjusting for prevalent heart disease and cognitive impairment. CONCLUSION: Symptoms of sleep apnea are reported less frequently in older Japanese-American men. Excessive daytime sleepiness is associated with poor cognition and dementia, but whether it also is an indicator for sleep apnea in this age group remains unclear. Epidemiologic studies of sleep apnea in older adults will require polysomnography to determine accurately the correlates and consequences of this condition.


Assuntos
Asiático , Doenças Cardiovasculares/complicações , Doenças Cardiovasculares/epidemiologia , Transtornos Cognitivos/complicações , Transtornos Cognitivos/epidemiologia , Síndromes da Apneia do Sono/complicações , Síndromes da Apneia do Sono/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Doenças Cardiovasculares/mortalidade , Transtornos Cognitivos/mortalidade , Havaí/epidemiologia , Humanos , Japão/etnologia , Estudos Longitudinais , Masculino , Prevalência , Síndromes da Apneia do Sono/mortalidade
19.
J Gerontol A Biol Sci Med Sci ; 50(5): M280-4, 1995 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-7671031

RESUMO

BACKGROUND: Sleep complaints have been reported in epidemiologic studies to be more frequent in late life, among females, among the physically impaired, and among persons experiencing psychiatric disorders. To date, however, no studies have reported a racial difference in sleep complaints among older persons in the United States. METHOD: The Duke EPESE (Established Populations for Epidemiologic Studies of the Elderly) assessed 3,976 community-dwelling elders age 65+ for sleep complaints and relevant control variables. RESULTS: In bivariate analyses, sleep complaints were associated with female gender, White race, older age, cognitive impairment, lower education, presence of chronic health conditions, poor self-rated health, and higher scores on a self-rated depression scale (the CES-D). In logistic regression analysis, the association of White race and more sleep complaints persisted (p < .001) when the above variables were simultaneously controlled. CONCLUSIONS: Fewer reported sleep complaints in community-dwelling Black elders compared to White elders remains unexplained, though it may be secondary to a higher threshold for Black elders reporting complaints.


Assuntos
Envelhecimento/fisiologia , Grupos Raciais , Transtornos do Sono-Vigília/etnologia , Transtornos do Sono-Vigília/epidemiologia , Idoso , Feminino , Inquéritos Epidemiológicos , Humanos , Incidência , Masculino , Análise de Regressão
20.
Gerontologist ; 35(1): 119-21, 1995 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-7890197

RESUMO

Circumstances in the last 3 days of life were examined for a sample of 1,227 elderly decedents in Fairfield County, Connecticut, in 1985. Interviews were with a surviving next-of-kin or a nonrelative about 3 months after the event of death. Most decedents were in a hospital or a nursing home the night before death (45% and 24%, respectively). In the days preceding death, about 34% of the decedents knew that death was impending and about 40% had difficulty recognizing family members. These and other findings support the need for elderly people to complete advance directives.


Assuntos
Atitude Frente a Morte , Morte , Família , Participação do Paciente/legislação & jurisprudência , Diretivas Antecipadas/legislação & jurisprudência , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Inquéritos e Questionários , Estados Unidos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA