Detalhe da pesquisa
1.
Formation of large oligomers of DOPAL-modified α-synuclein is modulated by the oxidation of methionine residues located at C-terminal domain.
Biochem Biophys Res Commun
; 509(2): 367-372, 2019 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30591215
2.
Exploring the role of methionine residues on the oligomerization and neurotoxic properties of DOPAL-modified α-synuclein.
Biochem Biophys Res Commun
; 505(1): 295-301, 2018 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249394
3.
Conjugation with polyamines enhances the antitumor activity of naphthoquinones against human glioblastoma cells.
Anticancer Drugs
; 29(6): 520-529, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29561308
4.
Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL).
J Biol Chem
; 290(46): 27660-79, 2015 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26381411
5.
Structure-function studies on jaburetox, a recombinant insecticidal peptide derived from jack bean (Canavalia ensiformis) urease.
Biochim Biophys Acta
; 1840(3): 935-44, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24239686
6.
Gut Microbiome Imbalance and Neuroinflammation: Impact of COVID-19 on Parkinson's Disease.
Mov Disord
; 35(9): 1495-1496, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32822087
7.
Pitfalls associated with the use of Thioflavin-T to monitor anti-fibrillogenic activity.
Bioorg Med Chem Lett
; 24(14): 3194-8, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24835632
8.
Fibrillation of α-synuclein triggered by bacterial endotoxin and lipid vesicles is modulated by N-terminal acetylation and familial Parkinson's disease mutations.
FEBS J
; 291(6): 1151-1167, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38069536
9.
Alpha-synuclein in Parkinson's disease: a villain or tragic hero? A critical view of the formation of α-synuclein aggregates induced by dopamine metabolites and viral infection.
Expert Rev Neurother
; 23(4): 321-330, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37016954
10.
Glycation modulates superoxide dismutase 1 aggregation and toxicity in models of sporadic amyotrophic lateral sclerosis.
Biochim Biophys Acta Mol Basis Dis
; 1869(8): 166835, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37558009
11.
Could the Urease of the Gut Bacterium Proteus mirabilis Play a Role in the Altered Gut-Brain Talk Associated with Parkinson's Disease?
Microorganisms
; 11(8)2023 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37630602
12.
The dopamine receptor agonist apomorphine stabilizes neurotoxic α-synuclein oligomers.
FEBS Lett
; 596(3): 309-322, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34928512
13.
The Role of Membrane Affinity and Binding Modes in Alpha-Synuclein Regulation of Vesicle Release and Trafficking.
Biomolecules
; 12(12)2022 12 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36551244
14.
Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO.
Bioorg Med Chem
; 19(24): 7416-24, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22071524
15.
Membrane-disruptive properties of the bioinsecticide Jaburetox-2Ec: implications to the mechanism of the action of insecticidal peptides derived from ureases.
Biochim Biophys Acta
; 1794(12): 1848-54, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19751848
16.
Viral Infection-Induced Gut Dysbiosis, Neuroinflammation, and α-Synuclein Aggregation: Updates and Perspectives on COVID-19 and Neurodegenerative Disorders.
ACS Chem Neurosci
; 11(24): 4012-4016, 2020 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33244974
17.
In Vitro Protective Action of Monomeric and Fibrillar α-Synuclein on Neuronal Cells Exposed to the Dopaminergic Toxins Salsolinol and DOPAL.
ACS Chem Neurosci
; 11(21): 3541-3548, 2020 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33080132
18.
Role of Parkinson's Disease-Linked Mutations and N-Terminal Acetylation on the Oligomerization of α-Synuclein Induced by 3,4-Dihydroxyphenylacetaldehyde.
ACS Chem Neurosci
; 10(1): 690-703, 2019 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30352158
19.
Insights into the role and structure of plant ureases.
Phytochemistry
; 69(1): 18-28, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17706733
20.
In vitro neurotoxicity of salsolinol is attenuated by the presynaptic protein α-synuclein.
Biochim Biophys Acta Gen Subj
; 1862(12): 2835-2845, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30251672