Multilevel analysis of ADHD, anxiety and depression symptoms aggregation in families.

A strong genetic role in the etiology of attention-deficit hyperactivity disorder (ADHD) has been demonstrated by several studies using different methodologies. Shortcomings of genetic studies often include the lack of golden standard practices for diagnosis for ADHD, the use of categorical instead of a dimensional approach, and the disregard for assortative mating phenomenon in parents. The current study aimed to overcome these shortcomings and analyze data through a novel statistical approach, using multilevel analyses with Bayesian procedures and a specific mathematical model, which takes into account data with an elevated number of zero responses (expected in samples with few or no ADHD symptoms). Correlations of parental clinical variables (ADHD, anxiety and depression) to offspring psychopathology may vary according to gender and type of symptoms. We aimed to investigate how those variables interact within each other. One hundred families, comprising a proband child or adolescent with ADHD or a typically developing child or adolescent were included and all family members (both biological parents, the proband child or adolescent and their sibling) were examined through semi-structured interviews using DSM-IV criteria. Results indicated that: (a) maternal clinical variables (ADHD, anxiety and depression) were more correlated with offspring variables than paternal ones; (b) maternal inattention (but not hyperactivity) was correlated with both inattention and hyperactivity in the offspring; (c) maternal anxiety was correlated with offspring inattention; on the other hand, maternal inattention was correlated with anxiety in the offspring. Although a family study design limits the possibility of revealing causality and cannot disentangle genetic and environmental factors, our findings suggest that ADHD, anxiety and depression are variables that correlate in families and should be addressed together. Maternal variables significantly correlated with offspring variables, but the paternal variables did not.

Use of the Brazilian version of the Interpersonal Negotiation Strategies Interview (INSI) in a child and adolescent sample: a pilot study.

INTRODUCTION: Interpersonal negotiation skills (INS) comprise actions used to solve social situations between interacting individuals involving different needs or desires. These abilities are part of one's social competence and may be impaired in some psychiatric conditions. There are few validated psychometric tools for measuring INS in the literature. This pilot study aimed to investigate some basic psychometric properties of the Brazilian version of the Interpersonal Negotiation Strategies Interview (INSI) in children and adolescents. METHODS: We developed a new version of the INSI adapted to the Brazilian culture using eight different dilemmas in dyadic situations (with peers and adults), presented visually as drawings on cards. A group of psychologists and psychiatrists chose and adapted the dilemmas formerly proposed by the original version. The same scoring criteria as for the original instrument were used. A total of 20 children and adolescents were included in this pilot study. We investigated test reliability using measures of interrater reliability, test-retest, and internal consistency. The content validity of the INSI was also evaluated by comparison with scores from the Child Behavior Checklist-Revised (CBCL). RESULTS: Internal consistency and test-retest evaluations were acceptable (rater 1: α = 0.77; rater 2: α = 0.72); the reliability of the instrument was excellent (K = 0.078; intraclass correlation coefficient = 0.98; 95% confidence interval 0.97-0.99); and content validity was strongly significant (p < 0.001). CONCLUSIONS: Preliminary results suggest that this version of the INSI has good interrater reliability and internal consistency and constitutes a promising tool to assess social competence.

Disregarding Impairment in ADHD Diagnosis Inflates Its Prevalence.

Diagnostic and Statistical Manual of Mental Disorders-fifth edition (DSM-V) diagnostic criteria for attention-deficit hyperactivity disorder (ADHD) has reemphasized impairment although many studies have demonstrated that such approach may inflate prevalence rates. However, there is no consensus on how impairment should be measured and a myriad of approaches in different studies make comparisons difficult. Objective: To investigate whether impairment measured using a previous validate quantitative measure modifies prevalence rates in a sample of Brazilian children and adolescents. Method: Of 109 children (72 males, 37 females), mean age of 12.4 years, 68 were with ADHD (according to DSM criteria, except for impairment) and 41 were typically developing children. All were evaluated with semi-structured interviews and completed the Functional Impairment Scale (FIS). Results: Thirty-five percent of ADHD cases had impairment in one single domain or no impairment at all (among school performance, social life, family life, and self-perception) in the FIS. Conclusion: Disregarding impairment clearly inflates ADHD diagnosis.

Impulsivity as an Endophenotype in ADHD: Negative Findings.

Impulsivity has a strong genetic component and is considered an endophenotype in many psychiatric disorders. Impulsivity in adult ADHD has become a focus of interest more recently because of its suggested prominence in this age. Objective: This study aimed to access self-reported impulsivity levels in biological parents of ADHD offspring, according to their status: non-ADHD (controls), remitted, nonremitted. Method: Impulsivity levels of 155 parents of ADHD children were compared according to their status using the Barratt Impulsiveness Scale (BIS-11). Results: The ADHD group presented the highest levels of impulsivity compared with all other groups. The remitted ADHD and control groups showed no significant differences in impulsivity levels. Conclusion: Impulsivity tended to remit alongside ADHD symptoms in remitters and to persist in those presenting with the residual form of adult ADHD suggesting it should not be considered as an endophenotype. Only the attentional dimension was impaired, cautioning against Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) impulsivity proposed criteria.

Mind-wandering, depression, anxiety and ADHD: Disentangling the relationship.

BACKGROUND: Mind Wandering (MW) has been associated with ADHD in a very small number of studies with adults and children. However, anxiety and depression have also been associated with MW and both are often comorbid with ADHD. The aim of this study was to investigate the role of anxiety and depression in MW in patients with ADHD. METHODS: The Mind Excessively Wandering Scale (MEWS) compared the levels of MW controlling for the presence of anxiety and depression symptoms in 78 adolescents (53 males and 25 females) comprising ADHD, clinical controls and typically developing individuals. Correlational analysis between MEWS score, demographic variables, ADHD, anxiety and depressive symptoms was performed using simple and multiple linear regression analysis demonstrating that only anxiety predicted MW scores. On a second analysis, we compared Anxiety and Non-Anxiety as well as ADHD and non-ADHD groups. RESULTS: Levels of MW were significantly correlated with anxiety symptoms, but not with depression. In addition, there were no differences in ADHD and non-ADHD groups regarding MW levels. CONCLUSIONS: Our results suggest MW is associated with anxiety levels, independently of an ADHD diagnosis.

Transcultural adaptation to Portuguese of the Mind Excessively Wandering Scale (MEWS) for evaluation of thought activity.

INTRODUCTION: The concept of mind wandering refers to periods during which attention and content of thoughts depart from the original idea or activity being performed. The phenomenon occurs commonly in the general population and the Mind Wandering Excessively Scale (MEWS) evaluates its frequency, intensity and related negative outcomes. OBJECTIVE: To describe the cross-cultural adaptation of the MEWS. METHODS: Cross-cultural adaptation of the original scale followed five consecutive steps: translation, backtranslation, appreciation of semantic equivalence and administration to a convenience sample to 20 adults with attention deficit hyperactivity disorder (ADHD) and 20 normal controls. RESULTS: Results indicated a satisfactory equivalence between the original and translated versions. A synthesis version for Brazilian Portuguese is presented. CONCLUSIONS: MEWS provides information on thought activity, which is particularly important in ADHD cases. The Brazilian Portuguese version would be welcome to address specific treatment responses and obtain new outcome measures.

Use of the Brazilian version of the Interpersonal Negotiation Strategies Interview (INSI) in a child and adolescent sample: a pilot study

Abstract Introduction Interpersonal negotiation skills (INS) comprise actions used to solve social situations between interacting individuals involving different needs or desires. These abilities are part of one's social competence and may be impaired in some psychiatric conditions. There are few validated psychometric tools for measuring INS in the literature. This pilot study aimed to investigate some basic psychometric properties of the Brazilian version of the Interpersonal Negotiation Strategies Interview (INSI) in children and adolescents. Methods We developed a new version of the INSI adapted to the Brazilian culture using eight different dilemmas in dyadic situations (with peers and adults), presented visually as drawings on cards. A group of psychologists and psychiatrists chose and adapted the dilemmas formerly proposed by the original version. The same scoring criteria as for the original instrument were used. A total of 20 children and adolescents were included in this pilot study. We investigated test reliability using measures of interrater reliability, test-retest, and internal consistency. The content validity of the INSI was also evaluated by comparison with scores from the Child Behavior Checklist-Revised (CBCL). Results Internal consistency and test-retest evaluations were acceptable (rater 1: α = 0.77; rater 2: α = 0.72); the reliability of the instrument was excellent (K = 0.078; intraclass correlation coefficient = 0.98; 95% confidence interval 0.97-0.99); and content validity was strongly significant (p < 0.001). Conclusions Preliminary results suggest that this version of the INSI has good interrater reliability and internal consistency and constitutes a promising tool to assess social competence.

Transcultural adaptation to Portuguese of the Mind Excessively Wandering Scale (MEWS) for evaluation of thought activity / Adaptação transcultural da Mind Excessively Wandering Scale para avaliação de atividade mental

Abstract Introduction: The concept of mind wandering refers to periods during which attention and content of thoughts depart from the original idea or activity being performed. The phenomenon occurs commonly in the general population and the Mind Wandering Excessively Scale (MEWS) evaluates its frequency, intensity and related negative outcomes. Objective: To describe the cross-cultural adaptation of the MEWS. Methods: Cross-cultural adaptation of the original scale followed five consecutive steps: translation, backtranslation, appreciation of semantic equivalence and administration to a convenience sample to 20 adults with attention deficit hyperactivity disorder (ADHD) and 20 normal controls. Results: Results indicated a satisfactory equivalence between the original and translated versions. A synthesis version for Brazilian Portuguese is presented. Conclusions: MEWS provides information on thought activity, which is particularly important in ADHD cases. The Brazilian Portuguese version would be welcome to address specific treatment responses and obtain new outcome measures

Resumo Introdução: O conceito de devaneio se refere a períodos nos quais a atenção e o conteúdo do pensamento de distanciam da ideia original ou da atividade que estava sendo realizada. O fenômeno ocorre na população em geral, e a Escala Mind Excessively Wandering Scale (MEWS) avalia sua frequência, intensidade e desfechos negativos associados. Objetivos: Descrever a adaptação transcultural da MEWS. Métodos: A adaptação transcultural envolveu cinco etapas: tradução, retrotradução, apreciação da equivalência semântica e administração em amostra de conveniência composta de 20 adultos com transtorno do déficit de atenção com hiperatividade (TDAH) e 20 controles normais. Resultados: Os resultados demonstraram equivalência satisfatória entre as versões original e traduzida. Uma versão síntese para o português brasileiro é apresentada. Conclusão: A MEWS fornece informações importantes sobre atividade mental, algo particularmente importante em casos de TDAH. A versão em português brasileiro deverá ser bem acolhida, permitindo investigar respostas específicas ao tratamento e obter novas medidas de desfechos.

Is ADHD a risk factor independent of conduct disorder for illicit substance use? A meta-analysis and metaregression investigation.

OBJECTIVE: To investigate meta-analytically if the association between ADHD and illicit substance use (ISU) is maintained when controlling for conduct disorder/oppositional-defiant disorder (CD/ODD). METHOD: A systematic literature review was conducted through Medline from 1980 to 2008. Data extracted and selections made by one author were reviewed by another. RESULTS: Fifteen articles presented odds ratios (ORs) for the development of ISU in individuals with ADHD controlling for CD/ODD. In total, the study covered results for more than 1,000 individuals. The combined OR for studies that included in their analysis exclusively ISU was 1.35 (0.90-2.03), p = .15, heterogeneity = 55%. Lack of control for socioeconomic status was related with a weaker association between ADHD and ISU. CONCLUSION: The existing data do not indicate that ADHD increases the risk of ISU beyond the effects of CD/ODD. However, the combination of all existing data is limited in power to detect a small increase in chance.

Quantitative measurement of impairment in ADHD: perspectives for research and clinical practice

BACKGROUND Functional impairment is needed to make an attention deficit hyperactivity disorder (ADHD) diagnosis, but there is a paucity of instruments addressing this issue. OBJECTIVE Perform psychometric analysis of a functional impairment scale (FIE). METHODS A sample of 320 individuals, including ADHD probands, their siblings and parents, filled the FIE. We analyzed psychometric properties for the entire sample and age groups. Factor structure was determined by a principal component factor analysis, using oblique rotation with Kaiser normalization and Eigenvalues higher than 1. Cronbach’s alpha and Spearman-Brown were calculated. RESULTS Family analysis revealed four components: a) “family life”, b) “self-perception”, c) “performance” and d) “social life”. Adults’ analysis revealed two components: a) “family life, social life and self-perception” and b) “performance”. Children showed the domains: a) “performance and social life”, b) “self-perception” and c) “family life” components. Cronbach’s alpha were above 0.9 in all components. DISCUSSION Results revealed up to four domains depending on the group considered. Different life demands might explain the variability of domains on the groups. .

Concordância entre relato de pais e professores para sintomas de TDAH: resultados de uma amostra clínica brasileira / Agreement rates between parents' and teachers' reports on ADHD symptomatology: findings from a Brazilian clinical sample

CONTEXTO: O diagnóstico de TDAH em crianças e adolescentes, segundo os critérios do DSM-IV, requer que os sintomas estejam presentes em, ao menos, dois ambientes distintos (principalmente escola e casa). Apesar da importância do relato de pais e professores, esse tema tem sido pouco investigado no Brasil. OBJETIVO: Investigar a concordância entre os relatos de pais e professores de uma amostra clínica de crianças e adolescentes com diagnóstico de TDAH. MÉTODOS: A amostra era composta por 44 crianças e adolescentes com idades variando entre 6 e 16 anos (40 meninos e 4 meninas), com diagnóstico clínico de TDAH. Foram comparadas as respostas de pais e professores no questionário SNAP-IV, visando a calcular taxas de concordância entre diferentes fontes de informação para sintomas de TDAH. RESULTADOS: Concordância para o diagnóstico de TDAH ocorreu em aproximadamente metade dos casos; pais relataram mais sintomas de TDAH que professores. CONCLUSÃO: Os achados aqui apresentados podem mostrar que informações acerca da sintomatologia de TDAH não são bem divulgadas para professores brasileiros, indicando a necessidade de se investir em sessões educacionais sobre o transtorno, tendo em vista a importância do relato de profissionais de educação para o diagnóstico de TDAH.

BACKGROUND: ADHD diagnosis in children and adolescents according to DSM-IV criteria demands symptoms to be present in at least two different settings (mainly school and home). Despite the importance in obtaining parents' and teachers' reports, this issue is seldom investigated in Brazil. OBJECTIVE: We set to evaluate agreement rates between parents' and teachers' reports from a Brazilian clinical sample of children and adolescents with ADHD. METHODS: The sample comprised 44 children and adolescents with age range between 6 and 16 years old (boys: 40; girls: 4) with a clinical diagnosis of ADHD. We compared parents' and teachers' responses in SNAP-IV questionnaire in order to calculate agreement rates among different information sources on ADHD symptomatology. RESULTS: Agreement for ADHD diagnosis occurred in nearly half of the sample, with parents' reporting more ADHD symptomatology than teachers. CONCLUSION: Our findings might suggest that recognition of ADHD symptomatology is less clear-cut among school teachers in Brazil, indicating that some educational sessions about this condition should be conducted in schools, taking into consideration the importance of education professionals' reports to diagnose ADHD.

ADHD: the impact when not diagnosed / TDAH: o impacto da ausência do diagnóstico

ADHD is a highly prevalent disorder in childhood with social, academic and familial difficulties when not diagnosed and treated correctly. The aim of this case report is to demonstrate the impairment of ADHD among generations of the same family.

O TDAH é uma doença de alta prevalência na infância, ocasionando dificuldades sociais, acadêmicas e familiares quando não diagnosticado e tratado adequadamente. O objetivo desse estudo de caso é demonstrar o grave prejuízo causado pelo TDAH em três gerações de uma mesma família.

Dificuldades no diagnóstico de TDAH em crianças / Challenges in diagnosing ADHD in children

O transtorno do déficit de atenção e/ou hiperatividade (TDAH) é uma doença de alta prevalência em crianças em idade escolar. Erroneamente entendido anteriormente como um diagnóstico de baixa morbidade, o TDAH é reconhecido atualmente como uma condição importante, não só pelo forte impacto funcional e social como também pela alta prevalência de comorbidades psiquißtricas. Déficits cognitivos globais e transtornos invasivos do desenvolvimento assim como transtornos do aprendizado são condições complexas que, quando estão associadas aos sintomas de TDAH, têm seus quadros agravados, requerendo maior atenção e estratégias de tratamento mais individualizadas. O objetivo deste artigo é uma discussão sobre esses diagnósticos diferenciais que representam um desafio na prática clínica.

Attention deficit/hyperactivity disorder (ADHD) is a highly prevalent disorder among school age children. Once understood as a common and mild disorder restricted to childhood, ADHD is now recognized as an important condition because of its poor outcome and strong association with comorbidities. Pervasive disorders and cognitive deficits, as well as learning disorders, are complex conditions and their co-ocurrence with ADHD is commonly associated with marked impairments and disabilities. These patients need more attention and personalized treatment strategies. The aim of this article is to establish a discussion about these differential diagnoses, which are a challenge in clinical practice.