Detalhe da pesquisa
1.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 522(7556): 315-20, 2015 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085270
2.
Screening a protein kinase inhibitor library against Plasmodium falciparum.
Malar J
; 16(1): 446, 2017 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29115999
3.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
4.
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
Nature
; 464(7289): 728-32, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20360736
5.
Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.
Antimicrob Agents Chemother
; 57(7): 2913-22, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23571538
6.
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.
J Med Chem
; 66(13): 8896-8916, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37343180
7.
Quinol derivatives as potential trypanocidal agents.
Bioorg Med Chem
; 20(4): 1607-15, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22264753
8.
High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules.
Biochem J
; 432(1): 21-33, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20854259
9.
Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.
J Biol Chem
; 284(52): 36137-36145, 2009 Dec 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19828449
10.
Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase.
Anal Biochem
; 396(2): 194-203, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19748480
11.
Acetazolamide-based fungal chitinase inhibitors.
Bioorg Med Chem
; 18(23): 8334-40, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21044846
12.
Substituted Aminoacetamides as Novel Leads for Malaria Treatment.
ChemMedChem
; 14(14): 1329-1335, 2019 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31188540
13.
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.
J Med Chem
; 61(18): 8374-8389, 2018 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30207721
14.
Target assessment for antiparasitic drug discovery.
Trends Parasitol
; 23(12): 589-95, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17962072
15.
The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines.
Cell Chem Biol
; 24(8): 981-992.e4, 2017 Aug 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28781123
16.
Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.
J Med Chem
; 60(23): 9790-9806, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29125744
17.
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy.
J Med Chem
; 59(21): 9672-9685, 2016 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27631715
18.
Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials.
J Med Chem
; 59(13): 6101-20, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27314305
19.
Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library.
ChemMedChem
; 10(11): 1809-20, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26381210
20.
Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.
ChemMedChem
; 10(11): 1821-36, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26395087