The functional state of thymus cells following microwave exposure of endocrine glands.

Following local microwave exposure (460 MHz, 120 mW/cm2) of rabbits using fluorescent probes and chemiluminescent analysis, conformational rearrangements in nuclear and cytoplasmic membranes and in thymus cell chromatin of the animals as well as changes in the intensity of the lipid free radical peroxidation were seen. The character of the changes observed depended both on the localization of the exposure and on the number of exposures.

[Immunosuppressive effect of the decimeter-band electromagnetic field]. / Immunodepressivnoe deistvie élektromagnitnogo polia detsimetrovogo diadazona.

The action of ultrahigh frequency (UHF) waves on the projection zone of the adrenal glands has been found to suppress both primary and secondary immune response, which is probably due to an increase in the glucocorticoid function of the adrenal cortex. The synthesis of nonspecific immunoglobulins has proved to be more resistant to the suppressive action of UHF than the synthesis of specific immunoglobulins.

[The immunomodulating action of microwaves in the induction of an immune response to Vi antigen]. / Immunomoduliruiushchee deistvie mikrovoln pri induktsii immunnogo otveta na Vi-antigen.

In this work the possibility of using microwaves for immunomodulation in the immunization of animals with thymus-independent antigen was studied. The projection zones of the thymus and adrenal glands of the test animals were subjected to the action of decimeter, or ultrahigh frequency (UHF), waves, while the corresponding zones of the control animals were subjected to imitation UHF irradiation. Vi-antigen was shown to be a thymus-independent antigen for rabbits (according to the results of the evaluation of the functional state of thymocytes, as manifested by the adsorption of acridine orange by the chromatin of thymocyte nuclei and by the content of RNA and DNA in the thymus). The action of UHF waves on the projection zone of the thymus was accompanied by a decrease in the glucocorticoid activity of the adrenal cortex, observed simultaneously with a pronounced immunostimulating effect. The UHF irradiation of the zone of the adrenal glands was accompanied by immunosuppression in combination with enhanced glucocorticoid activity of the adrenal cortex.

[Changes in binding of corticosteroids by transcortin in blood and in oxidative processes in rabbit liver mitochondria under the effect of decimeter waves]. / Izmenenie suiazyvaniia lortikosteroidov transkottinom v krovi i okislitel'nykh protsessov v mitokhondriiakh pecheni krolikov pod vliianiem detsimetrovykh voln

Irradiation of rabbits with decimetre waves (regions of adrenal glands, liver and lower part of thigh) was accompanied by an increased content of free, biologically active corticosteroids in blood plasma due to liberation of the substances from a complex with transcortine. This phenomenon correlated with activation of the electron transport in respiratory chain of liver tissue mitochondria. The irradiation of the liver region caused distinct alteration in mitochondrial functions apparently due to intensified effect of the decimetre waves directly on the liver tissue.

[The action of decimeter waves and merkazolil on myocardial metabolism in the rabbit and its hormonal regulation]. / Deistvie detsimetrovykh voln i merkazolila na metabolizm miokarda krolika i ego gormonal'nuiu reguliatsiiu.

Oxidative and biosynthetic processes in the myocardium, blood serum thyroid hormones, thyroid and adrenal morphometric characteristics were investigated in rabbits upon the exposure of their thyroid projection zone to decimeter waves (460 MHz, 10 mW/cm2), administration of mercazolil (150 mg) given in courses and upon combined use of these modalities. Mercazolil was found to modulate the responses of the studied systems to the waves. This may be explained by feasible regulatory effect of the waves on mercazolil-induced changes in rabbit functions.

[The effect of decimeter waves on the metabolism of the myocardium and its hormonal regulation in rabbits with experimental ischemia]. / Vliianie detsimetrovykh voln na metabolizm miokarda i ego gormonal'nuiu reguliatsiiu u krolikov s éksperimental'noi ishemiei.

Biochemical and morphometric methods were employed to study the effect of decimetric waves (460 MHz, 10 and 120 mW/cm2) in cardiac and thyroid exposure on oxygen metabolism, myocardial microcirculation and contractility, thyroid and adrenal hormonal activity, kallikrein-kinin system activity in rabbits with experimental myocardial ischemia. Hypoxia discontinued in all the treatment regimens, but the exposure of the heart (field density 10 mW/sm2) had the additional effect on lipid peroxidation which reduced in the serum and normalized in the myocardium, on myocardial contractility, kallikrein-kinin system and on the adrenal and thyroid hormones.

[The immunological and hormonal effects of combined exposure to a bitemporal ultrahigh-frequency electrical field and to decimeter waves at different sites]. / Immunologicheskie i gormonal'nye éffekty sochetannogo vozdeistviia élektricheskogo polia ul'travysokoi chastoty bitemporal'no i detsimetrovykh voln razlichnoi lokalizatsii.

Bitemporal UHF electric field is shown to enhance glucocorticoid adrenal function unlike inhibition of the thyroid function suppressing a primary immune response (PIR) in the productive phase. The combined exposure to bitemporal UHF electric field and decimeter waves of the adrenals doubles glucocorticoid synthesis abolishing the inhibitory action of the UHF therapy on thyroid function resultant in much more suppressed PIR. Both modalities inhibit thymic production. Decimeter waves alone are less effective. The exposure of the thyroid to decimeter waves initiated PIR by 2.5-fold activation of medullar lymphocytes and by a 80% increase in the thymic function. No response was achieved in combined action on the thyroid of the electric field and decimeter waves.

[The immune and hormonal effects of the local action of microwaves of different intensities]. / Immunnye i gormonal'nye éffekty lokal'nogo vozdeistviia mikrovoln razlichnoi intensivnosti.

The trend in immune and hormonal parameters in thyroid, adrenal and transcerebral exposure to microwaves with intensity of 120, 240 and 480 mW/cm2 was studied in rabbits. The thyroid exposure to 120 and 240 mW/cm2 microwaves lead to immunostimulation, while adrenal and transcerebral one induced immunosuppression. The exposure to 240 mW/cm2 and 480 mW/cm2 microwaves resulted in damage to the tissues in 56 and 100% of the animals, respectively. The latter irradiation appeared lethal for 25% of the rabbits. 120 mW/cm2 MV proved safe as there were no signs of edema and necrosis seen with more intensive microwaves. The authors suggest to employ microwaves of 120 mW/cm2 intensity for endocrine glands irradiation to produce an immunomodulating effect.

[The dynamics of the immunobiological effects in transcerebral microwave exposures]. / Dinamika immunobiologicheskikh éffektov pri transtserebral'nykh mikrovolnovykh vozdeistviiakh.

The trend in immunobiological responses to transcerebral action of decimeter microwaves was studied in intact rabbits. Transcerebral microwaves (120 mW/cm2) can alter functional activity of certain links of endocrine system due to possible activation of hypothalamus and hypophysis exposed to microwave electromagnetic field. Such exposure given in courses at early stages leads to an increase in the number of antibody-forming cells in the spleen, whereas total number of splenocytes is on the decrease.