Speech Perception Performance in Cochlear Implant Recipients Correlates to the Number and Synchrony of Excited Auditory Nerve Fibers Derived From Electrically Evoked Compound Action Potentials.

OBJECTIVES: Many studies have assessed the performance of individuals with cochlear implants (CIs) with electrically evoked compound action potentials (eCAPs). These eCAP-based studies have focused on the amplitude information of the response, without considering the temporal firing properties of the excited auditory nerve fibers (ANFs), such as neural latency and synchrony. These temporal features have been associated with neural health in animal studies and, consequently, could be of importance to clinical CI outcomes. With a deconvolution method, combined with a unitary response, the eCAP can be mathematically unraveled into the compound discharge latency distribution (CDLD). The CDLD reflects both the number and the temporal firing properties of excited ANFs. The present study aimed to determine to what extent the CDLD derived from intraoperatively recorded eCAPs is related to speech perception in individuals with CIs. DESIGN: This retrospective study acquired data on monosyllabic word recognition scores and intraoperative eCAP amplitude growth functions from 124 adult patients with postlingual deafness that received the Advanced Bionics HiRes 90K device. The CDLD was determined for each recorded eCAP waveform by deconvolution. Each of the two Gaussian components of the CDLD was described by three parameters: the amplitude, the firing latency (the average latency of each component of the CDLD), and the variance of the CDLD components (an indication of the synchronicity of excited ANFs). Apart from these six CDLD parameters, the area under the CDLD curve (AUCD) and the slope of the AUCD growth function were determined as well. The AUCD was indicative of the total number of excited ANFs over time. The slope of the AUCD growth function indicated the increases in the number of excited ANFs with stimulus level. Associations between speech perception and each of these eight CDLD-related parameters were investigated with linear mixed modeling. RESULTS: In individuals with CIs, larger amplitudes of the two CDLD components, greater AUCD, and steeper slopes of the AUCD growth function were all significantly associated with better speech perception. In addition, a smaller latency variance in the early CDLD component, but not in the late, was significantly associated with better speech recognition scores. Speech recognition was not significantly dependent on CDLD latencies. The AUCD and the slope of the AUCD growth function provided a similar explanation of the variance in speech perception (R 2 ) as the eCAP amplitude, the slope of the amplitude growth function, the amplitude, and variance of the first CDLD component. CONCLUSION: The results demonstrate that both the number and the neural synchrony of excited ANFs, as revealed by CDLDs, are indicative of postimplantation speech perception in individuals with a CI. Because the CDLD-based parameters yielded a higher significance than the eCAP amplitude or the AGF slope, the authors conclude that CDLDs can serve as a clinical predictor of the survival of ANFs and that they have predictive value for postoperative speech perception performance. Thus, it would be worthwhile to incorporate the CDLD into eCAP measures in future clinical applications.

Full-array channel discrimination in cochlear implants: validation and clinical application.

OBJECTIVE: We sought to validate our proposed tool for estimating channel discrimination of cochlear implant (CI) users along the full electrode array and to assess associations between place-pitch discrimination and speech perception. DESIGN: In two tests, participants identified one stimulus (probe) as the odd-one-out compared with two reference stimuli. Probe stimuli were evoked using dual electrode stimulation characterised by the current steering coefficient α. The first test measured psychometric functions (PFs) on pre-defined contacts, with just a noticeable difference (JNDα) as the outcome variable. The second test estimated channel discrimination on the full electrode array, yielding a discrimination score of Dα. We measured speech perception as free-field consonant-vowel-consonant phoneme recognition scores. STUDY SAMPLE: We included 25 adults with at least 6 months of CI experience. RESULTS: JNDα and Dα scores measured on the same contact correlated significantly (rs = 0.64, p < 0.001). Mean JNDα and speech perception scores showed significant relationships in quiet and in noise. CONCLUSIONS: Dα correlated strongly with JNDα scores obtained with the PFs. For poor performers, the full-array test may underestimate JNDα. The full-array pitch discrimination test could be a helpful clinical tool, such as for fitting regions of lesser pitch discrimination ability.

Diagnostic value of preoperative measures in selecting post-lingually deafened candidates for cochlear implantation - a different approach.

OBJECTIVES: We examined which preoperative diagnostic measure is most suited to serve as a selection criterion to determine adult cochlear implantation (CI) candidacy. DESIGN: Preoperative diagnostic measures included pure tone audiometry (PTA; 0.5, 1, 2, 4 kHz), speech perception tests (SPT) unaided with headphones and with best-aided hearing aids (in quiet and in noise). Gain in speech perception was used as outcome measure. Performance of preoperative measures was analysed using the area under the curve (AUC) of receiver operating characteristic (ROC) curves. STUDY SAMPLE: This retrospective longitudinal cohort study included 552 post-lingually deafened adults with CI in a tertiary referral centre in the Netherlands. RESULTS: Best-aided SPT in quiet was the most accurate in defining which CI candidates improved their speech perception in quiet postoperatively. For an improvement in speech perception in noise, the best-aided SPT in noise was the most accurate in defining which adult would benefit from CI. PTA measures performed lower compared to the SPT measures. CONCLUSIONS: SPT is better than PTA for selecting CI candidates who will benefit in terms of speech perception. Best-aided SPT in noise was the most accurate for indicating an improvement of speech perception in noise but was only evaluated in high performers with residual hearing. These insights will assist in formulating more effective selection criteria for CI.

Residual Hearing Affects Contralateral Routing of Signals in Cochlear Implant Users.

INTRODUCTION: Contralateral routing of signals (CROS) can be used to eliminate the head shadow effect. In unilateral cochlear implant (CI) users, CROS can be achieved with placement of a microphone on the contralateral ear, with the signal streamed to the CI ear. CROS was originally developed for unilateral CI users without any residual hearing in the nonimplanted ear. However, the criteria for implantation are becoming progressively looser, and the nonimplanted ear can have substantial residual hearing. In this study, we assessed how residual hearing in the contralateral ear influences CROS effectiveness in unilateral CI users. METHODS: In a group of unilateral CI users (N = 17) with varying amounts of residual hearing, we deployed free-field speech tests to determine the effects of CROS on the speech reception threshold (SRT) in amplitude-modulated noise. We compared 2 spatial configurations: (1) speech presented to the CROS ear and noise to the CI ear (SCROSNCI) and (2) the reverse (SCINCROS). RESULTS: Compared with the use of CI only, CROS improved the SRT by 6.4 dB on average in the SCROSNCI configuration. In the SCINCROS configuration, however, CROS deteriorated the SRT by 8.4 dB. The benefit and disadvantage of CROS both decreased significantly with the amount of residual hearing. CONCLUSION: CROS users need careful instructions about the potential disadvantage when listening in conditions where the CROS ear mainly receives noise, especially if they have residual hearing in the contralateral ear. The CROS device should be turned off when it is on the noise side (SCINCROS). CI users with residual hearing in the CROS ear also should understand that contralateral amplification (i.e., a bimodal hearing solution) will yield better results than a CROS device. Unilateral CI users with no functional contralateral hearing should be considered the primary target population for a CROS device.

Hearing Status Affects Children's Emotion Understanding in Dynamic Social Situations: An Eye-Tracking Study.

OBJECTIVES: For children to understand the emotional behavior of others, the first two steps involve emotion encoding and emotion interpreting, according to the Social Information Processing model. Access to daily social interactions is prerequisite to a child acquiring these skills, and barriers to communication such as hearing loss impede this access. Therefore, it could be challenging for children with hearing loss to develop these two skills. The present study aimed to understand the effect of prelingual hearing loss on children's emotion understanding, by examining how they encode and interpret nonverbal emotional cues in dynamic social situations. DESIGN: Sixty deaf or hard-of-hearing (DHH) children and 71 typically hearing (TH) children (3-10 years old, mean age 6.2 years, 54% girls) watched videos of prototypical social interactions between a target person and an interaction partner. At the end of each video, the target person did not face the camera, rendering their facial expressions out of view to participants. Afterward, participants were asked to interpret the emotion they thought the target person felt at the end of the video. As participants watched the videos, their encoding patterns were examined by an eye tracker, which measured the amount of time participants spent looking at the target person's head and body and at the interaction partner's head and body. These regions were preselected for analyses because they had been found to provide cues for interpreting people's emotions and intentions. RESULTS: When encoding emotional cues, both the DHH and TH children spent more time looking at the head of the target person and at the head of the interaction partner than they spent looking at the body or actions of either person. Yet, compared with the TH children, the DHH children looked at the target person's head for a shorter time (b = -0.03, p = 0.030), and at the target person's body (b = 0.04, p = 0.006) and at the interaction partner's head (b = 0.03, p = 0.048) for a longer time. The DHH children were also less accurate when interpreting emotions than their TH peers (b = -0.13, p = 0.005), and their lower scores were associated with their distinctive encoding pattern. CONCLUSIONS: The findings suggest that children with limited auditory access to the social environment tend to collect visually observable information to compensate for ambiguous emotional cues in social situations. These children may have developed this strategy to support their daily communication. Yet, to fully benefit from such a strategy, these children may need extra support for gaining better social-emotional knowledge.

Detection of Translocation of Cochlear Implant Electrode Arrays by Intracochlear Impedance Measurements.

OBJECTIVES: Misplacement of the electrode array is associated with impaired speech perception in patients with cochlear implants (CIs). Translocation of the electrode array is the most common misplacement. When a CI is translocated, it crosses the basilar membrane from the scala tympani into the scala vestibuli. The position of the implant can be determined on a postoperative CT scan. However, such a scan is not obtained routinely after CI insertion in many hospitals, due to radiation exposure and processing time. Previous studies have shown that impedance measures might provide information on the placement of the electrode arrays. The electrode impedance was measured by dividing the plateau voltage at the end of the first phase of the pulse by the injected current. The access resistance was calculated using the so-called access voltage at the first sampled time point after the start of the pulse divided by the injected current. In our study, we obtained the electrode impedance and the access resistance to detect electrode translocations using electrical field imaging. We have investigated how reliably these two measurements can detect electrode translocation, and which method performed best. DESIGN: We calculated the electrode impedances and access resistances using electrical field imaging recordings from 100 HiFocus Mid-Scala CI (Advanced Bionics, Sylmar, CA) recipients. We estimated the normal values of these two measurements as the baselines of the implant placed in the cochlea without translocation. Next, we calculated the maximal electrode impedance deviation and the maximal access-resistance deviation from the respective baselines as predictors of translocation. We classified these two predictors as translocations or nontranslocations based on the bootstrap sampling method and receiver operating characteristics curves analysis. The accuracy could be calculated by comparing those predictive results to a gold standard, namely the clinical CT scans. To determine which measurement more accurately detected translocation, the difference between the accuracies of the two measurements was calculated. RESULTS: Using the bootstrap sampling method and receiver operating characteristics-based optimized threshold criteria, the 95% confidence intervals of the accuracies of translocation detections ranged from 77.8% to 82.1% and from 89.5% to 91.2% for the electrode impedance and access resistance, respectively. The accuracies of the maximal access-resistance deviations were significantly larger than that of the maximal electrode impedance deviations. The location of the translocation as predicted by the access resistance was significantly correlated with the result derived from the CT scans. In contrast, no significant correlation was observed for the electrode impedance. CONCLUSIONS: Both the electrode impedance and access resistance proved reliable metrics to detect translocations for HiFocus Mid-Scala electrode arrays. The access resistance had, however, significantly better accuracy and it also reliably detected the electrode-location of translocations. The electrode impedance did not correlate significantly with the location of translocation. Measuring the access resistance is, therefore, the recommended method to detect electrode-array translocations. These measures can provide prompt feedback for surgeons after insertion, improving their surgical skills, and ultimately reducing the number of translocations. In the future, such measurements may allow near-real-time monitoring of the electrode array during insertion, helping to avoid translocations.

Personalizing Transient Noise Reduction Algorithm Settings for Cochlear Implant Users.

OBJECTIVES: Speech understanding in noise is difficult for patients with a cochlear implant. One common and disruptive type of noise is transient noise. We have tested transient noise reduction (TNR) algorithms in cochlear implant users to investigate the merits of personalizing the noise reduction settings based on a subject's own preference. DESIGN: The effect of personalizing two parameters of a broadband and a multiband TNR algorithm (TNRbb and TNRmb, respectively) on speech recognition was tested in a group of 15 unilaterally implanted subjects in cafeteria noise. The noise consisted of a combination of clattering dishes and babble noise. Each participant could individually vary two parameters, namely the scaling factor of the attenuation and the release time (τ). The parameter τ represents the duration of the attenuation applied after a transient is detected. As a reference, the current clinical standard TNR "SoundRelax" from Advanced Bionics was tested (TNRbb-std). Effectiveness of the algorithms on speech recognition was evaluated adaptively by determining the speech reception threshold (SRT). Possible subjective benefits of the algorithms were assessed using a rating task at a fixed signal-to-noise ratio (SNR) of SRT + 3 dB. Rating was performed on four items, namely speech intelligibility, speech naturalness, listening effort, and annoyance of the noise. Word correct scores were determined at these fixed speech levels as well. RESULTS: The personalized TNRmb improved the SRT statistically significantly with 1.3 dB, while the personalized TNRbb degraded it significantly by 1.7 dB. For TNRmb, we attempted to further optimize its settings by determining a group-based setting, leaving out those subjects that did not experience a benefit from it. Using these group-based settings, however, TNRmb did not have a significant effect on the SRT any longer. TNRbb-std did not affect speech recognition significantly. No significant effects on subjective ratings were found for any of the items investigated. In addition, at a constant speech level of SRT + 3 dB, no effect of any of the algorithms was found on word correct scores, including TNRmb with personalized settings. CONCLUSIONS: Our study results indicate that personalizing noise reduction settings of a multiband TNR algorithm can significantly improve speech intelligibility in transient noise, but only under challenging listening conditions around the SRT. At more favorable SNRs (SRT + 3 dB), this benefit was lost. We hypothesize that TNRmb was beneficial at lower SNRs, because of more effective artifact detection under those conditions. Group-averaged settings of the multiband algorithm did not significantly affect speech recognition. TNRbb decreased speech recognition significantly using personalized parameter settings. Rating scores were not significantly affected by the algorithms under any condition tested. The currently available TNR algorithm for Advanced Bionics systems (SoundRelax) is a broadband filter that does not support personalization of its settings. Future iterations of this algorithm might benefit from upgrading it to a multiband variant with the option to personalize its parameter settings.

SoftVoice Improves Speech Recognition and Reduces Listening Effort in Cochlear Implant Users.

OBJECTIVES: The ability to perceive soft speech by cochlear implant (CI) users is restricted in part by the inherent system noise produced by the speech processor, and in particular by the microphone(s). The algorithm "SoftVoice" (SV) was developed by Advanced Bionics to enhance the perception of soft speech by reducing the system noise in speech processors. The aim of this study was to examine the effects of SV on speech recognition and listening effort. DESIGN: Seventeen adult Advanced Bionics CI recipients were recruited and tested in two sessions. The effect of SV on speech recognition was tested by determining the SRT in quiet using the Matrix test. Based on the individual subjects' SRTs, we investigated speech-recognition scores at fixed speech levels, namely SRT -5 dB, SRT +0 dB, SRT +5 dB, and SRT +10 dB, again in quiet and using the Matrix test. Listening effort was measured at each of these speech levels subjectively by using a rating scale, and objectively by determining pupil dilation with pupillometry. To verify whether SoftVoice had any negative effects on speech perception in noise, we determined the SRT in steady state, speech-weighted noise of 60 dBA. RESULTS: Our results revealed a significant improvement of 2.0 dB on the SRT in quiet with SoftVoice. The average SRT in quiet without SoftVoice was 38 dBA. SoftVoice did not affect the SRT in steady state, speech-weighted noise of 60 dB. At an average speech level of 33 dBA (SRT -5 dB) and 38 dBA (SRT +0 dB) in quiet, significant improvements of 17% and 9% on speech-recognition scores were found with SoftVoice, respectively. At higher speech levels, SoftVoice did not significantly affect speech recognition. Pupillometry did not show significant effects of SoftVoice at any speech level. However, subjective ratings of listening effort indicated a decrease of listening effort with SoftVoice at a speech level of 33 dBA. CONCLUSIONS: We conclude that SoftVoice substantially improves recognition of soft speech and lowers subjective listening effort at low speech levels in quiet. However, no significant effect of SoftVoice was found on pupil dilation. As SRTs in noise were not statistically significantly affected by SoftVoice, we conclude that SoftVoice can be used in noisy listening conditions with little negative impact on speech recognition, if any. The increased power demands of the algorithm are considered to be negligible. It is expected that SoftVoice will reduce power consumption at low ambient sound levels. These results support the use of SoftVoice as a standard feature of Advanced Bionics CI fittings for everyday use.

Selection Criteria for Cochlear Implantation in the United Kingdom and Flanders: Toward a Less Restrictive Standard.

OBJECTIVES: The impact of the newly introduced cochlear implantation criteria of the United Kingdom and Flanders (Dutch speaking part of Belgium) was examined in the patient population of a tertiary referral center in the Netherlands. We compared the patients who would be included/excluded under the new versus old criteria in relation to the actual improvement in speech understanding after implantation in our center. We also performed a sensitivity analysis to examine the effectiveness of the different preoperative assessment approaches used in the United Kingdom and Flanders. DESIGN: The selection criteria were based on preoperative pure-tone audiometry at 0.5, 1, 2, and 4 kHz and a speech perception test (SPT) with and without best-aided hearing aids. Postoperatively, the same SPT was conducted to assess the benefit in speech understanding. RESULTS: The newly introduced criteria in Flanders and the United Kingdom were less restrictive, resulting in greater percentages of patients implanted with CI (increase of 30%), and sensitivity increase of 31%. The preoperative best-aided SPT, used by both countries, had the highest diagnostic ability to indicate a postoperative improvement of speech understanding. We observed that patient selection was previously dominated by the pure-tone audiometry criteria in both countries, whereas speech understanding became more important in their new criteria. Among patients excluded by the new criteria, seven of eight (the United Kingdom and Flanders) did exhibit improved postoperative speech understanding. CONCLUSIONS: The new selection criteria of the United Kingdom and Flanders led to increased numbers of postlingually deafened adults benefitting from CI. The new British and Flemish criteria depended on the best-aided SPT with the highest diagnostic ability. Notably, the new criteria still led to the rejection of candidates who would be expected to gain considerably in speech understanding after implantation.

Factors Influencing Speech Perception in Adults With a Cochlear Implant.

OBJECTIVES: The primary objective of this study is to identify the biographic, audiologic, and electrode position factors that influence speech perception performance in adult cochlear implant (CI) recipients implanted with a device from a single manufacturer. The secondary objective is to investigate the independent association of the type of electrode (precurved or straight) with speech perception. DESIGN: In a cross-sectional study design, speech perception measures and ultrahigh-resolution computed tomography scans were performed in 129 experienced CI recipients with a postlingual onset of hearing loss. Data were collected between December 2016 and January 2018 in the Radboud University Medical Center, Nijmegen, the Netherlands. The participants received either a precurved electrode (N = 85) or a straight electrode (N = 44), all from the same manufacturer. The biographic variables evaluated were age at implantation, level of education, and years of hearing loss. The audiometric factors explored were preoperative and postoperative pure-tone average residual hearing and preoperative speech perception score. The electrode position factors analyzed, as measured from images obtained with the ultrahigh-resolution computed tomography scan, were the scalar location, angular insertion depth of the basal and apical electrode contacts, and the wrapping factor (i.e., electrode-to-modiolus distance), as well as the type of electrode used. These 11 variables were tested for their effect on three speech perception outcomes: consonant-vowel-consonant words in quiet tests at 50 dB SPL (CVC50) and 65 dB SPL (CVC65), and the digits-in-noise test. RESULTS: A lower age at implantation was correlated with a higher CVC50 phoneme score in the straight electrode group. Other biographic variables did not correlate with speech perception. Furthermore, participants implanted with a precurved electrode and who had poor preoperative hearing thresholds performed better in all speech perception outcomes than the participants implanted with a straight electrode and relatively better preoperative hearing thresholds. After correcting for biographic factors, audiometric variables, and scalar location, we showed that the precurved electrode led to an 11.8 percentage points (95% confidence interval: 1.4-20.4%; p = 0.03) higher perception score for the CVC50 phonemes compared with the straight electrode. Furthermore, contrary to our initial expectations, the preservation of residual hearing with the straight electrode was poor, as the median preoperative and the postoperative residual hearing thresholds for the straight electrode were 88 and 122 dB, respectively. CONCLUSIONS: Cochlear implantation with a precurved electrode results in a significantly higher speech perception outcome, independent of biographic factors, audiometric factors, and scalar location.

Cost-benefit Analysis of Cochlear Implants: A Societal Perspective.

OBJECTIVES: While the costs and outcomes of cochlear implantation (CI) have been widely assessed, most of these analyses were solely performed from the perspective of healthcare costs. This study assesses the costs and benefits of CI in the Netherlands from a broader societal perspective, including health outcomes, healthcare cost, educational cost, and productivity losses and gains. DESIGN: The cost and benefits of CI were analyzed in this cost-benefit analysis, in which a monetary value is put on both the resources needed and the outcomes of CI. The costs and benefits were analyzed by prototypical instances of three groups, representing the majority of cochlear implant patients: prelingually deaf children implanted at the age of 1, adults with progressive profound hearing loss implanted at the age of 40 and seniors implanted at the age of 70 with progressive profound hearing loss. Costs and benefits were estimated over the expected lifetimes of the members of each group, using a Markov state transition model. Model parameters and assumptions were based on published literature. Probabilistic and one-way sensitivity analyses were performed. RESULTS: In all three patient groups, the total benefits of CI exceeded the total cost, leading to a net benefit of CI. Prelingually deaf children with a bilateral CI had a lifetime positive outcome net benefit of €433,000. Adults and seniors with progressive profound hearing loss and a unilateral CI had a total net benefit of €275,000 and €76,000, respectively. These results ensue from health outcomes expressed in monetary terms, reduced educational cost, and increased productivity. CONCLUSIONS: Based on estimates from modeling, the increased healthcare costs due to CI were more than compensated by the value of the health benefits and by savings in educational and productivity costs. In particular, for children and working adults, the societal benefit was positive even without taking health benefits into account. Therefore, CI generates an advantage for both patients and society.

Emotions in Deaf and Hard-of-Hearing and Typically Hearing Children.

For deaf and hard-of-hearing (DHH) children living in an environment where their access to linguistic input and social interactions is compromised, learning emotions could be difficult, which may further affect social functioning. To understand the role of emotion in DHH children's social life, this study investigated emotional functioning (i.e., emotion recognition, empathy, emotion expression), and its relation with social functioning (i.e., social competence and externalizing behaviors), in 55 DHH children and 74 children with typical hearing (aged 3-10 years; Mage = 6.04). Parental reports on children's emotional and social functioning and factors related to DHH children's hearing were collected. Results showed similar levels of emotional and social functioning in children with and without hearing loss. Use of auditory intervention and speech perception did not correlate with any measures in DHH children. In both groups, higher levels of empathy related to higher social competence and fewer externalizing behaviors; emotion recognition and positive emotion expression were unrelated to either aspect of social functioning. Higher levels of negative emotion expression related to lower social competence in both groups, but to more externalizing behaviors in DHH children only. DHH children in less linguistically accessible environments may not have adequate knowledge for appropriately expressing negative emotions socially.

The School Career of Children With Hearing Loss in Different Primary Educational Settings-A Large Longitudinal Nationwide Study.

Children with hearing loss (HL) are at risk for a lower educational achievement. This longitudinal study compared the school career of a nationwide Dutch cohort with and without HL based on descriptive data of the governmental authority Statistics Netherlands. From 2008 to 2018, 3,367,129 children, of whom 1,193 used cochlear implants (CIs) and 8,874 used hearing aids (HAs), were attending primary and/or secondary education. Sixty-one percent of children with HL attended mainstream and 31% special primary education. Compared to mainstreamed pupils without HL, mainstreamed pupils with HL achieved lower levels for language and mathematics in primary education but eventually attended comparable types of secondary education. Children with HL attending special primary education attained lower types of secondary education compared to mainstreamed peers with and without HL. These findings suggest that future educational (and as a result professional) attainment of a child with HL depends on the type of primary educational setting.

Multimodal imaging of hair follicle bulge-derived stem cells in a mouse model of traumatic brain injury.

Traumatic brain injury (TBI) is a devastating event for which current therapies are limited. Stem cell transplantation may lead to recovery of function via different mechanisms, such as cell replacement through differentiation, stimulation of angiogenesis and support to the microenvironment. Adult hair follicle bulge-derived stem cells (HFBSCs) possess neuronal differentiation capacity, are easy to harvest and are relatively immune-privileged, which makes them potential candidates for autologous stem cell-based therapy. In this study, we apply in vivo multimodal, optical and magnetic resonance imaging techniques to investigate the behavior of mouse HFBSCs in a mouse model of TBI. HFBSCs expressed Luc2 and copGFP and were examined for their differentiation capacity in vitro. Subsequently, transduced HFBSCs, preloaded with ferumoxytol, were transplanted next to the TBI lesion (cortical region) in nude mice, 2 days after injury. Brains were fixed for immunohistochemistry 58 days after transplantation. Luc2- and copGFP-expressing, ferumoxytol-loaded HFBSCs showed adequate neuronal differentiation potential in vitro. Bioluminescence of the lesioned brain revealed survival of HFBSCs and magnetic resonance imaging identified their localization in the area of transplantation. Immunohistochemistry showed that transplanted cells stained for nestin and neurofilament protein (NF-Pan). Cells also expressed laminin and fibronectin but extracellular matrix masses were not detected. After 58 days, ferumoxytol could be detected in HFBSCs in brain tissue sections. These results show that HFBSCs are able to survive after brain transplantation and suggest that cells may undergo differentiation towards a neuronal cell lineage, which supports their potential use for cell-based therapy for TBI.

Effectiveness of Phantom Stimulation in Shifting the Pitch Percept in Cochlear Implant Users.

OBJECTIVES: Phantom electrode stimulation was developed for cochlear implant (CI) systems to provide a lower pitch percept by stimulating more apical regions of the cochlea, without inserting the electrode array deeper into the cochlea. Phantom stimulation involves simultaneously stimulating a primary and a compensating electrode with opposite polarity, thereby shifting the electrical field toward the apex and eliciting a lower pitch percept. The current study compared the effect sizes (in shifts of place of excitation) of multiple phantom configurations by matching the perceived pitch with phantom stimulation to that perceived with monopolar stimulation. Additionally, the effects of electrode location, type of electrode array, and stimulus level on the perceived pitch were investigated. DESIGN: Fifteen adult advanced bionics CI users participated in this study, which included four experiments to eventually measure the shifts in place of excitation with five different phantom configurations. The proportions of current delivered to the compensating electrode, expressed as σ, were 0.5, 0.6, 0.7, and 0.8 for the symmetrical biphasic pulses (SBC0.5, SBC0.6, SBC0.7, and SBC0.8) and 0.75 for the pseudomonophasic pulse shape (PSA0.75). A pitch discrimination experiment was first completed to determine which basal and apical electrode contacts should be used for the subsequent experiments. An extensive loudness balancing experiment followed where both the threshold level (T-level) and most comfortable level (M-level) were determined to enable testing at multiple levels of the dynamic range. A pitch matching experiment was then performed to estimate the shift in place of excitation at the chosen electrode contacts. These rough shifts were then used in the subsequent experiment, where the shifts in place of excitation were determined more accurately. RESULTS: Reliable data were obtained from 20 electrode contacts. The average shifts were 0.39, 0.53, 0.64, 0.76, and 0.53 electrode contacts toward the apex for SBC0.5, SBC0.6, SBC0.7, SBC0.8, and PSA0.75, respectively. When only the best configurations per electrode contact were included, the average shift in place of excitation was 0.92 electrode contacts (range: 0.25 to 2.0). While PSA0.75 leads to equal results as the SBC configurations in the apex, it did not result in a significant shift at the base. The shift in place of excitation was significantly larger at the apex and with lateral wall electrode contacts. The stimulus level did not affect the shift. CONCLUSIONS: Phantom stimulation results in significant shifts in place of excitation, especially at the apical part of the electrode array. The phantom configuration that leads to the largest shift in place of excitation differs between subjects. Therefore, the settings of the phantom electrode should be individualized so that the phantom stimulation is optimized for each CI user. The real added value to the sound quality needs to be established in a take-home trial.

Simulating intracochlear electrocochleography with a combined model of acoustic hearing and electric current spread in the cochlea.

Intracochlear electrocochleography (ECochG) is a potential tool for the assessment of residual hearing in cochlear implant users during implantation and acoustical tuning postoperatively. It is, however, unclear how these ECochG recordings from different locations in the cochlea depend on the stimulus parameters, cochlear morphology, implant design, or hair cell degeneration. In this paper, a model is presented that simulates intracochlear ECochG recordings by combining two existing models, namely a peripheral one that simulates hair cell activation and a three-dimensional (3D) volume-conduction model of the current spread in the cochlea. The outcomes were compared to actual ECochG recordings from subjects with a cochlear implant (CI). The 3D volume conduction simulations showed that the intracochlear ECochG is a local measure of activation. Simulations showed that increasing stimulus frequency resulted in a basal shift of the peak cochlear microphonic (CM) amplitude. Increasing the stimulus level resulted in wider tuning curves as recorded along the array. Simulations with hair cell degeneration resulted in ECochG responses that resembled the recordings from the two subjects in terms of CM onset responses, higher harmonics, and the width of the tuning curve. It was concluded that the model reproduced the patterns seen in intracochlear hair cell responses recorded from CI-subjects.

Dynamic Current Focusing: A Novel Approach to Loudness Coding in Cochlear Implants.

OBJECTIVES: In an attempt to improve spectral resolution and speech intelligibility, several current focusing methods have been proposed to increase spatial selectivity by decreasing intracochlear current spread. For example, tripolar stimulation administers current to a central electrode and uses the two flanking electrodes as the return pathway, creating a narrower intracochlear electrical field and hence increases spectral resolution when compared with monopolar (MP) stimulation. However, more current is required, and in some patients, specifically the ones with high electrode impedances, full loudness growth cannot be supported because of compliance limits. The present study describes and analyses a new loudness encoding approach that uses tripolar stimulation near threshold and gradually broadens the excitation (by decreasing compensation coefficient σ) to increase loudness without the need to increase overall current. It is hypothesized that this dynamic current focusing (DCF) strategy increases spatial selectivity, especially at lower loudness levels, while maintaining maximum selectivity at higher loudness levels, without reaching compliance limits. DESIGN: Eleven adult cochlear implant recipients with postlingual hearing loss, with at least 9 months of experience with their HiRes90K implant, were selected to participate in this study. Baseline performance regarding speech intelligibility in noise (Dutch matrix sentence test), spectral ripple discrimination at 45 and 65 dB, and temporal modulation detection thresholds were assessed using their own clinical program, fitted on a Harmony processor. Subsequently, the DCF strategy was fitted on a research Harmony processor. Threshold levels were determined with σ = 0.8, which means 80% of current is returned to the flanking electrodes and the remaining 20% to the extracochlear ground electrode. Instead of increasing overall pulse magnitude, σ was decreased to determine most comfortable loudness. After 2 to 3 hr of adaptation to the research strategy, the same psychophysical measures were taken. RESULTS: At 45 dB, average spectral ripple scores improved significantly from 2.4 ripples per octave with their clinical program to 3.74 ripples per octave with the DCF strategy (p = 0.016). Eight out of 11 participants had an improved spectral resolution at 65 dB. Nevertheless, no significant difference between DCF and MP was observed at higher presentation levels. Both speech-in-noise and temporal modulation detection thresholds were equal for MP and DCF strategies. Subjectively, 2 participants preferred the DCF strategy over their own clinical program, 2 preferred their own strategy, while the majority of the participants had no preference. Battery life was decreased and ranged from 1.5 to 4 hr. CONCLUSIONS: The DCF strategy gives better spectral resolution, at lower loudness levels, but equal performance on speech tests. These outcomes warrant for a longer adaptation period to study long-term outcomes and evaluate if the outcomes in the ripple tests transfer to the speech scores. Further research, for example, with respect to fitting rules and reduction of power consumption, is necessary to make the DCF strategy suitable for routine clinical application.

Test/Retest Variability of the eCAP Threshold in Advanced Bionics Cochlear Implant Users.

OBJECTIVE: The reliability of the electrically evoked compound action potential (eCAP) threshold depends on its precision and accuracy. The precision of the eCAP threshold reflects its variability, while the accuracy of the threshold shows how close it is to the actual value. The objective of this study was to determine the test/retest variability of the eCAP threshold in Advanced Bionics cochlear implant users, which has never been reported before. We hypothesized that the test/retest variability is dependent on the presence of random noise in the recorded eCAP waveforms. If this holds true, the recorded error should be reduced by approximately the square-root of the number of averages. As secondary objectives, we assessed the effects of the slope of the amplitude growth function (AGF), cochlear location, and eCAP threshold on eCAP threshold precision. We hypothesized that steeper slopes should result in better precision of the linearly extrapolated eCAP threshold. As other studies have shown that apical regions have steeper slopes and larger eCAPs, we recorded eCAPs in three different cochlear locations. The difference of the precision between two commonly applied stimulus-artifact reduction paradigms on eCAP threshold precision was compared, namely averaging of alternating stimulus polarities (AP averaging) and forward masking (FM). FM requires the addition of more waveforms than AP averaging, and hence we expected FM to have lower precision than AP. DESIGN: This was an unmasked, descriptive, and observational study with a cross-over (repeated measures) design that included 13 subjects. We recorded eCAPs on three electrode contacts: in the base, middle, and apex of the cochlea at 10 stimulus intensities. Per stimulus level, 256 eCAP waveforms were recorded. eCAP thresholds were determined by constructing AGFs and linear extrapolation to zero-amplitude. The precision of the eCAP threshold was calculated as the SD using a Monte Carlo simulation, as a function of the number of waveform averages. RESULTS: The SD of the eCAP threshold was reduced by approximately the square root of two when the number of averages in the eCAP waveforms was doubled. The precision was significantly better when the slope of the AGF was steeper and was more favorable in the cochlear base than in the apex. Precision was better when AP averaging was used. Absolute eCAP threshold did not significantly affect precision. At the default number of 32 waveform averages in the Advanced Bionics system, we report a median SD of the eCAP threshold of 2 to 3 µA, with a range of 1 to 11 µA across the cochlea. Previous studies have shown that the total error, based on the 95% confidence bounds of the linear extrapolation, can be as high as -260 to +120 µA. CONCLUSIONS: The median variability in the eCAP threshold proved to be small compared with the total variability introduced by the linear extrapolation method. Yet there was substantial intersubject variability. Therefore, we recommend monitoring the SD during eCAP recording to facilitate informed decisions when to terminate waveform collection. From a precision perspective, AP averaging is preferable over FM as it has better precision, while fewer recordings are needed, making it the more time-efficient method of the two.

Channel discrimination along all contacts of the cochlear implant electrode array and its relation to speech perception.

OBJECTIVE: To test the channel discrimination of cochlear implant (CI) users along all contacts of the electrode array and assess whether this is related to speech perception. DESIGN: CI recipients were tested with a custom-made channel discrimination test. They were asked to distinguish a target stimulus from two reference stimuli in a three-alternative forced choice (3AFC) task. The target stimulus was evoked using current steering, with current steering coefficients (α) of 1, 0.5 and 0.25. The test provided a discrimination score (Dα) for each electrode contact along the array. STUDY SAMPLE: Thirty adults implanted with a CI from Advanced Bionics. RESULTS: Large variations in Dα scores were observed, both across the electrode array and between subjects. Statistical analysis revealed a significant channel-to-channel variability in Dα score (p < 0.01). Further, there was a significant relationship between subjects' Dα scores and their speech perception in quiet (p < 0.001). CONCLUSIONS: The large variations in Dα score emphasise the importance of testing pitch discrimination across the complete electrode array. The relationship between Dα score and speech perception indicates that pitch discrimination might be a contributing factor to the performance of individual implant users.

Dynamic current focusing for loudness encoding in cochlear implants: a take-home trial.

Objective: This study aimed to evaluate a more energy-efficient dynamic current focussing (DCF) speech-processing strategy after long-term listening experience. In DCF, tripolar stimulation is used near the threshold and loudness is controlled by the compensation coefficient σ. A recent acute pilot study showed improved spectral-temporally modulated ripple test (SMRT) scores at low loudness levels, but battery life was reduced to 1.5-4 hours. Design: Within-subject comparisons were made for the clinical versus. DCF strategy after 5 weeks of at-home usage. Speech intelligibility in noise, spectral ripple discrimination, temporal modulation detection, loudness growth, and subjective ratings were assessed. Study sample: Twenty HiRes90K (Advanced Bionics, Valencia, USA) cochlear implant (CI) users. Results: Average battery life was 9 hours with the newly implemented DCF compared to 13.4 hours with the clinical strategy. Compared with measurements made at the beginning of the study, SMRT-scores and speech intelligibility in noise were significantly improved with DCF. However, both measures suffered from unexpected learning effects over time. The improvement disappeared and speech intelligibility in noise declined significantly relative to the final control measurement with the clinical strategy. Conclusion: Most CI users can adapt to the DCF strategy in a take-home setting. Although DCF has the potential to improve performance on the SMRT test, learning effects complicate the interpretation of the current results.