Detalhe da pesquisa
1.
Molecular dynamics-based identification of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91.
Mol Cell
; 84(5): 955-966.e4, 2024 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38325379
2.
Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast.
Nat Chem Biol
; 19(12): 1551-1560, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37932529
3.
Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors.
J Biol Chem
; 299(12): 105438, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37944618
4.
Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1.
Proc Natl Acad Sci U S A
; 116(14): 7123-7128, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30872479
5.
The Zinc-Sensing Receptor GPR39 in Physiology and as a Pharmacological Target.
Int J Mol Sci
; 22(8)2021 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33918078
6.
Preassociation between the 5-HT7 serotonin receptor and G protein Gs: molecular determinants and association with low potency activation of adenylyl cyclase.
FASEB J
; 33(3): 3870-3886, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30508496
7.
Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures.
Biophys J
; 116(10): 1823-1835, 2019 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31003762
8.
Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine.
Gastroenterology
; 155(4): 1164-1176.e2, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29935151
9.
Structural changes at the myrtenol backbone reverse its positive allosteric potential into inhibitory GABAA receptor modulation.
Biol Chem
; 399(6): 549-563, 2018 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29408795
10.
Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding.
J Biol Chem
; 291(31): 16208-20, 2016 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226537
11.
Biased Gs versus Gq proteins and ß-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond network.
J Biol Chem
; 290(40): 24495-508, 2015 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26269596
12.
Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists.
Bioorg Med Chem Lett
; 25(4): 887-92, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25599839
13.
Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7.
J Biol Chem
; 288(18): 12511-21, 2013 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-23493400
14.
Structural biology: Full monty of family B GPCRs.
Nat Chem Biol
; 13(8): 819-821, 2017 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28853739
15.
Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop.
J Biol Chem
; 287(40): 33488-502, 2012 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22846991
16.
PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation.
J Biol Chem
; 287(52): 43516-26, 2012 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23135271
17.
The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the ß2-adrenergic receptor.
J Biol Chem
; 287(38): 31973-82, 2012 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22843684
18.
Structure-activity relationships and identification of optmized CC-chemokine receptor CCR1, 5, and 8 metal-ion chelators.
J Chem Inf Model
; 53(11): 2863-73, 2013 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24083637
19.
Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach.
J Biol Chem
; 286(43): 37543-54, 2011 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21878623
20.
Unique interaction pattern for a functionally biased ghrelin receptor agonist.
J Biol Chem
; 286(23): 20845-60, 2011 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21402696