Detalhe da pesquisa
1.
Successive cleavage of ß-amyloid precursor protein by γ-secretase.
Semin Cell Dev Biol
; 105: 64-74, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32354467
2.
A nontoxigenic form of Shiga toxin 2 suppresses the production of amyloid ß by altering the intracellular transport of amyloid precursor protein through its receptor-binding B-subunit.
Biochem Biophys Res Commun
; 557: 247-253, 2021 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33894410
3.
A potential defense mechanism against amyloid deposition in cerebellum.
Biochem Biophys Res Commun
; 535: 25-32, 2021 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33340762
4.
γ-Secretase Activity Is Associated with Braak Senile Plaque Stages.
Am J Pathol
; 190(6): 1323-1331, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32201261
5.
Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy.
Genes Cells
; 23(1): 22-34, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29205725
6.
Glycosylation status of nicastrin influences catalytic activity and substrate preference of γ-secretase.
Biochem Biophys Res Commun
; 502(1): 98-103, 2018 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29787759
7.
Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization.
J Neurochem
; 140(6): 955-962, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28032911
8.
Affinity-Based Screening of Tetravalent Peptides Identifies Subtype-Selective Neutralizers of Shiga Toxin 2d, a Highly Virulent Subtype, by Targeting a Unique Amino Acid Involved in Its Receptor Recognition.
Infect Immun
; 84(9): 2653-61, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27382021
9.
γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of ß-carboxyl-terminal fragment.
J Biol Chem
; 289(8): 5109-21, 2014 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24375443
10.
Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3.
J Biol Chem
; 288(29): 20868-20882, 2013 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23723072
11.
The senile plaque: Morphological differences in APP knock-in mice brains by fixatives.
Brain Behav
; 13(4): e2953, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36879381
12.
A tailored tetravalent peptide displays dual functions to inhibit amyloid ß production and aggregation.
Commun Biol
; 6(1): 383, 2023 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37031306
13.
gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.
J Neurosci
; 29(41): 13042-52, 2009 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19828817
14.
The production ratios of AICDε51 and Aß42 by intramembrane proteolysis of ßAPP do not always change in parallel.
Psychogeriatrics
; 10(3): 117-23, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20860566
15.
Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation.
Cells
; 9(2)2020 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32028683
16.
Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells.
Mol Biol Cell
; 14(5): 1913-22, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12802064
17.
Dictyostelium PAKc is required for proper chemotaxis.
Mol Biol Cell
; 15(12): 5456-69, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15483055
18.
The A673T mutation in the amyloid precursor protein reduces the production of ß-amyloid protein from its ß-carboxyl terminal fragment in cells.
Acta Neuropathol Commun
; 3: 66, 2015 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26531305
19.
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.
Nat Commun
; 4: 2529, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24108142
20.
γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid ß-Protein Production.
Int J Alzheimers Dis
; 2012: 591392, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23346458