Detalhe da pesquisa
1.
Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.
J Med Chem
; 54(12): 4092-108, 2011 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21608528
2.
Design and total synthesis of a superior family of epothilone analogues, which eliminate xenograft tumors to a nonrelapsable state.
Angew Chem Int Ed Engl
; 42(39): 4762-7, 2003 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-14562342
3.
Synthesis and conformational analysis of (E)-9,10-dehydroepothilone B: a suggestive link between the chemistry and biology of epothilones.
Angew Chem Int Ed Engl
; 42(22): 2518-21, 2003 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12800175
4.
Total synthesis of reblastatin.
J Am Chem Soc
; 127(43): 15026-7, 2005 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-16248632
5.
Application of ring-closing metathesis reactions in the synthesis of epothilones.
J Nat Prod
; 67(2): 139-43, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-14987048
6.
Complex target-oriented total synthesis in the drug discovery process: the discovery of a highly promising family of second generation epothilones.
J Am Chem Soc
; 125(10): 2899-901, 2003 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-12617656
7.
Discovery of (E)-9,10-dehydroepothilones through chemical synthesis: on the emergence of 26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B as a promising anticancer drug candidate.
J Am Chem Soc
; 126(35): 10913-22, 2004 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15339176