RESUMO
The propyphenazone, a drug with pronounced anti-inflammatory, anti-fever, analgesic properties, is recommended in acute situations which require therapeutic blood levels in short time after administration. The review presented has the purpose of obtaining an oral lyophilizate, compared with the common tablets. Also, the specific parameters for oral solid dosage forms were determined. The procedure for the oral lyophilizate's preparation promotes the liquid form's mobility and activity, being designed as a solid product which disperses readily in small quantities of water. The presence of a solubilizing agent, included in formulation, will increase propyphenazone's dissolution and so, the analgesic, antiinflammatory effect will appear rapidly. The lyophilization of the selected formulation with a usifroid apparatus was conducted following the classic steps. The tablets were compared with compressed tablets having the same content in propyphenazone (0,250 g), being observed concerning the aspect, the diameter, the dissolution time and the percentage of dissolved substance in one hour. In comparison with compressed tablets, the substances associated in oral lyophilizate and the specific lyophilization technique determine propyphenazone's release in a shorter time interval.