Detalhe da pesquisa
1.
NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts.
Blood
; 141(13): 1584-1596, 2023 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36375120
2.
Structure and mechanism of the phage T4 recombination mediator protein UvsY.
Proc Natl Acad Sci U S A
; 113(12): 3275-80, 2016 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26951671
3.
Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies.
J Med Chem
; 67(4): 2321-2336, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38300987
4.
Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Science
; 383(6682): eadi5798, 2024 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38301010
5.
The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Staphylococcus aureus Dihydropteroate Synthase.
Front Microbiol
; 9: 1369, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30065703
6.
A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer.
Nat Struct Mol Biol
; 24(8): 666-671, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28714993
7.
Analysis of the active-site mechanism of tyrosyl-DNA phosphodiesterase I: a member of the phospholipase D superfamily.
J Mol Biol
; 415(4): 741-58, 2012 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22155078
8.
Crystal structure of the phage T4 recombinase UvsX and its functional interaction with the T4 SF2 helicase UvsW.
J Mol Biol
; 405(1): 65-76, 2011 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21035462