RESUMO
BACKGROUND: Erycibe paniculata Roxb. (Family-Convolvulaceae) has been reported for its potential ethno medicinal value. Leaf, stem, bark, and root of this plant are being used either single or in the mixture of the whole part in different disease conditions by different tribes. AIMS AND OBJECTIVES: The aim and objective of this study is to assess the antioxidant activity of methanolic extracts of different parts (leaf, stem, bark, and root) of Erycibe paniculata Roxb (E. paniculata). MATERIALS AND METHODS: Different in-vitro assay such as free radical-scavenging assay by 2,2-diphenyl-1-picryl-hydrazyl-hydrate method, reducing power, super oxide radical scavenging, nitric oxide, and hydrogen peroxide scavenging assays were used to determine the antioxidant activity of different parts of E. paniculata. Ascorbic acid, sodium nitrite, and gallic acid were used as the standards for antioxidant activity. RESULTS: The percentage inhibition for all methods were plotted against different concentration and suggested that the obtained activities were concentration and dose depended. Inhibitory concentration (IC50) value of methanolic extract of leaf, stem, bark, and root of E. paniculata in different in vitro activities exhibited significant antioxidant activity. Methanolic extract of bark showed higher IC50 value in all antioxidant assays than other parts of E. paniculata. CONCLUSION: Methanolic extract of leaf, stem, bark, and root of E. paniculata has potential antioxidant activity.