Detalhe da pesquisa
1.
Machine learning-based phenotypic imaging to characterise the targetable biology of Plasmodium falciparum male gametocytes for the development of transmission-blocking antimalarials.
PLoS Pathog
; 19(10): e1011711, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37801466
2.
Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites.
PLoS Pathog
; 18(10): e1010887, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36223427
3.
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34548400
4.
G6PD distribution in sub-Saharan Africa and potential risks of using chloroquine/hydroxychloroquine based treatments for COVID-19.
Pharmacogenomics J
; 21(6): 649-656, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34302047
5.
Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity.
Bioorg Chem
; 115: 105244, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34452759
6.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 522(7556): 315-20, 2015 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085270
7.
Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones.
J Comput Aided Mol Des
; 34(11): 1117-1132, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32833084
8.
Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria.
Antimicrob Agents Chemother
; 63(3)2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30559138
9.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
10.
A human microdose study of the antimalarial drug GSK3191607 in healthy volunteers.
Br J Clin Pharmacol
; 84(3): 482-489, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29168205
11.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
12.
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.
Proc Natl Acad Sci U S A
; 111(50): E5455-62, 2014 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453091
13.
Development of a Novel High-Density [3H]Hypoxanthine Scintillation Proximity Assay To Assess Plasmodium falciparum Growth.
Antimicrob Agents Chemother
; 60(10): 5949-56, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27458216
14.
A high-throughput fluorescence-based assay for Plasmodium dihydroorotate dehydrogenase inhibitor screening.
Anal Biochem
; 506: 13-21, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27133204
15.
A novel validated assay to support the discovery of new anti-malarial gametocytocidal agents.
Malar J
; 15(1): 385, 2016 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27448565
16.
Thousands of chemical starting points for antimalarial lead identification.
Nature
; 465(7296): 305-10, 2010 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20485427
17.
In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.
J Biol Chem
; 289(26): 17980-95, 2014 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24782313
18.
Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans.
Antimicrob Agents Chemother
; 59(2): 950-9, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25421480
19.
Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay.
Malar J
; 14: 441, 2015 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26542470
20.
Antimalarial drug resistance: new treatments options for Plasmodium.
Drug Discov Today Technol
; 11: 81-88, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24847657