The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-ß1 (TGF-ß1)/α-Smooth Muscle Actin (α-SMA) Pathway.

BACKGROUND Pneumoconiosis is a chronic progressive fibrotic interstitial pneumonia for which the pathogenesis and treatment remain unclear. Previous studies showed that sodium ferulate (SF) may have a therapeutic effect, and this study explored the mechanism underlying SF-related improvement. MATERIAL AND METHODS In this study, a silicosis mouse model and primary cultured mouse lung fibroblasts were established. Hematoxylin-eosin staining, western blot analysis, quantitative real-time polymerase chain reaction, and Masson staining were used to observe the lung injury, expression of vimentin, and the degree of pulmonary fibrosis. The extracted lung fibroblasts were identified by immunofluorescence. The expression of fibrosis-related genes encoding transforming growth factor-ß1 (TGF-ß1), neutrophil alkaline phosphatase 3 (NALP3), collagen-1, alpha-smooth muscle actin (alpha-SMA), and phosphorylated p38 (p-p38) and p38 proteins were detected by western blot. The effects of SF and the TGF-ß pathway agonist SRI-011381 on cell proliferation and the expression of fibrosis-related protein in mouse lung fibroblasts were measured by Cell Counting Kit-8, immunofluorescence, and western blot as needed. RESULTS SF reduced the lung lesions in silicosis mice and inhibited the expression of vimentin and fibrosis-related genes, while having no effect on body weight. Vimentin expression was positive in the extracted cells. In vitro experiments showed that SF inhibited the proliferation of lung fibroblasts and the expression of fibrosis-related proteins. In addition, SF partly reversed the opposite regulatory effect of SRI-011381 on lung fibroblasts. CONCLUSIONS SF inhibited lung injury and fibrosis in silicosis mice through the NALP3/TGF-ß1/alpha-SMA pathway.

N-Doped Mesoporous In2 O3 for Photocatalytic Oxygen Evolution from the In-based Metal-Organic Frameworks.

As an excellent n-type semiconductor, indium oxide (In2 O3 ) is also a good candidate for photocatalysis such as light-induced water splitting. However, the efficiency of the oxygen evolution reaction (OER) underperforms in view of the wide band gap (BG) and fast charge recombination in In2 O3 . N-doping provides a sound method to narrow the BG and to prohibit the charge recombination by forming new energy levels between the valence band (VB) and the conduction band (CB). In this work, an In-based organic framework sod-ZMOF was used as a precursor to prepare the N-doped In2 O3 . After calcination, sod-ZMOF is transformed into N-doped In2 O3 nanocrystalline, in which the ligand within sod-ZMOF serves as the nitrogen source. In addition, sod-ZMOF acts as self-template during calcination to generate abundant nanopores within the In2 O3 frameworks, providing large specific surface area and active sites for OER. The BG is narrowed to 2.9 from 3.7 eV of the pure In2 O3 on account of the N-doping. N species are doped in both the substitutional and interstitial fashion, and the interstitial doping is believed to improve the photo-induced carrier separation by the formation of oxygen vacancies. As a consequence, the overpotential for OER is effectively decreased from the pure In2 O3 , and the electrocatalytic experiment proves superior catalytic activity with a high current density and long-term durability compared to the In2 O3 nanoparticles obtained from In(OH)3 .

How do landscape patterns in urban parks affect multiple cultural ecosystem services perceived by residents?

Cultural ecosystem services (CES) provided by urban parks are crucial for encouraging residents to engage with nature and enhance their physical and mental well-being. Measuring these services from the residents' perception perspective is essential. Previous studies often focus on a specific type of CES, lacking explicit links between the landscape composition and configuration of urban parks and residents' perceptions of various CES. The main objective of this study, therefore, was to explore the effects of urban park landscape patterns on residents' CES perceptions. We took 12 urban parks in Chengdu, China, and assessed residents' CES perceptions through content analysis of social media texts. Spatial patterns of the parks were analyzed using remote sensing interpretation and field surveys. Correlation analysis examined the relationship between landscape patterns and residents' perceptions, with further verification through questionnaires and face-to-face interviews. Findings revealed that at the landscape level, landscape aggregation of parks was negatively correlated with aesthetic perceptions but positively correlated with recreational perceptions. Landscape diversity negatively impacted perceptions of sports and health (S&H). At the class level, natural elements significantly influenced residents' perceptions of aesthetic and S&H. Specifically, aesthetic perceptions were minimized when the landscape shape index of water bodies reached 6.36 or when the proportion of green space was 56.5 %. Road edge density negatively affected perceptions of S&H and influenced the distribution of water bodies and green spaces. These findings are crucial for optimizing park structures to deliver efficient CES and provide strategies for integrating ecosystem services into environmental management from a public perception perspective.

Estimating the effects of driving forces on ecosystem services and their responses to environmental conditions.

Understanding the factors driving ecosystem service (ES) change is essential for maintaining ES functions and achieving sustainable development. Although research on the spatial variations in the effects of driving forces on ESs provides guidance for regional ecological management, the responses of driving forces to environmental conditions have not been adequately investigated, especially in regions with high spatial heterogeneity. By using remote sensing images and socioeconomic data, this paper aims to fill this gap by estimating the spatial distribution characteristics of the effects of driving forces on ESs and their responses to different environmental conditions in Sichuan Province, China. First, the biophysical values of soil conservation (SC) and water yield (WY) were evaluated using ecological simulation models. Second, the spatial distribution of the effects of four driving forces on two services was explored using the geographically weighted regression (GWR) model. Finally, the responses of driving forces to environmental conditions were quantified by using scatter plots. The results revealed that the spatial patterns of SC and WY showed spatial heterogeneity. The effects of driving forces on ESs varied with space. Both positive and negative effects of driving forces were observed in Sichuan Province. Under different biophysical and socioeconomic conditions, the effects of driving forces on ESs showed different change trends, characterized by fluctuating trends and obvious thresholds. In our study area, urban sprawl, impervious surfaces, agricultural expansion, intensive human activities, and complex topographic features contributed to the variations in the effects of driving forces. Our results suggest that the responses of driving forces to different land-use coverage, topographical, NDVI, and socioeconomic conditions should be considered in ecological decision-making. Such research results are expected to manage the driving forces of ESs and serve as a practical reference for local management in order to maintain the functions of ESs and attain sustainable development.

Impact of urbanization on the food-water-land-ecosystem nexus: A study of Shenzhen, China.

The food-water-land-ecosystem (FWLE) nexus is fundamental for achieving sustainable development. This study examines the influence of urbanization on the FWLE nexus. Toward this end, land was deemed as an entry point. Therefore, the impact of urbanization on the nexus was explored based on changes in land use. We selected Shenzhen, a city in China, as the study area. First, a land change modeler was employed to analyze historical land-use changes from 2000 to 2010, to build transition potential submodels, and to project future land-use patterns for 2030 under a business-as-usual scenario. Second, based on land-use maps, we assessed habitat quality, water yield, and water supply from 2000 to 2030 using Integrated Valuation of Ecosystem Services and Tradeoffs. Moreover, crop production was estimated according to statistical materials. Finally, the study presents the analyses and discussion of the impacts of urbanization on ecosystem services related to the FWLE nexus. The results of land-use changes indicated that a significant expansion of artificial surfaces occurred in Shenzhen with varying degrees of decrease in cultivated land, forest, and grassland. Furthermore, habitat quality, water supply, and crop production decreased evidently due to rapid urbanization. In contrast, the total water yield indicated an upward trend owing to the increased water yield from increasing artificial surfaces, whereas water yield from other land-use areas declined, such as the forest and grassland. The results demonstrated a significant positive correlation between artificial surfaces and total water yield. However, negative correlations were observed in the interaction among habitat quality, water supply, and crop production. The study presented temporal and spatial assessments to provide an effective and convenient means of exploring the interactions and tradeoffs within the FWLE nexus, which, thus, contributed to the sustainable transformation of urbanization.

Integrating the effects of driving forces on ecosystem services into ecological management: A case study from Sichuan Province, China.

Driving forces are the factors that lead to the observed changes in the quantity and quality of ecosystem services (ESs). The relationship between driving forces and ESs involves considerable scale-related information. Place-based ecological management requires this information to support local sustainable development. Despite the importance of scale in ES research, most studies have only examined the association between ESs and their drivers at a single level, and few studies have examined this relationship at various scales or analyzed spatial heterogeneity. The purpose of this paper is to explore the significance of the scale-dependent effects of drivers on ESs for localized ecological management. The biophysical values of ESs were calculated using several ecological simulation models. The effects of driving forces on ESs were explored using the geographically weighted regression (GWR) model. Variations in the effects of driving forces on ESs were examined at three scales: provincial, ecoregional, and subecoregional scales. Finally, canonical correlation analysis was used to identify the major environmental factors associated with these variations in each ecoregion. Our results show that (1) the distribution of soil conservation and water yield is highly heterogeneous; (2) four driving forces have significant positive and negative impacts on soil conservation and water yield, and their effects on the two services vary spatially (p < 0.05); (3) the impacts of drivers on ESs vary across different spatial scales, with a corresponding shift in the related environmental factors; and (4) in the study area, at the provincial scale, physical, topographical, and biophysical factors were key factors associated with the variations in the relationship between ESs and drivers, and at the ecoregional and subecoregional scales, physical, socioeconomic, topographical, and biophysical factors all contributed to these changes. Our results suggest that significant differences in topographical conditions (e.g., altitude, slope) can be incorporated for exploring the relationship between drivers and ESs and optimizing ecological management at the provincial scale, whereas significant differences in physical and socioeconomic conditions (e.g., urbanization levels, human activity, vegetation coverage) are more meaningful for localized ecological management at the ecoregional and subecological scales. These findings provide a basis for understanding the relationship between drivers and ESs at multiple scales as well as guidelines for improving localized ecological management and achieving sustainable development.

Effect of supersaturation on hillock of directional Growth of KDP crystals.

KDP single crystals were grown in aqueous solution by using "point seeds" with a defined crystallographic direction of 59° to the Z axis. When hillock slopes on the (100) face of KDP crystals were measured within the supersaturation (σ) range of 0 < σ ≤ 0.06, the slope of hillocks with hollow cores depended nonlinearly on supersaturation. Below σ = 0.02, the hillock slope depended on supersaturation, but when σ was ≥ 0.02, the hillock slope increased more gradually and was less dependent on supersaturation. Hollow funnel-shaped growth dislocation on the (100) face of KDP crystals was observed at σ = 0.04, characterized by large holes with micro-steps and step bunching inside, the formation of which were analyzed. The result verified that the reversed growth appears to occur within hollow channels found on growth hillocks.