Detalhe da pesquisa
1.
Structural Characterization of 5-Substituted Pyrrolo[3,2-d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Biochemistry
; 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38324671
2.
The evolving biology of the proton-coupled folate transporter: New insights into regulation, structure, and mechanism.
FASEB J
; 36(2): e22164, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35061292
3.
Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site.
Bioorg Med Chem
; 82: 117217, 2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36889150
4.
Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents.
Molecules
; 27(1)2022 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35011550
5.
Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents.
Bioorg Med Chem Lett
; 41: 127923, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33705908
6.
Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.
Bioorg Med Chem
; 35: 116061, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33647840
7.
The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity.
Bioorg Med Chem
; 29: 115887, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33310545
8.
Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.
Bioorg Med Chem
; 37: 116093, 2021 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33773393
9.
Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
Mol Pharmacol
; 97(1): 9-22, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31707355
10.
Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier.
Bioorg Med Chem
; 28(12): 115544, 2020 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32503687
11.
Regulation of differential proton-coupled folate transporter gene expression in human tumors: transactivation by KLF15 with NRF-1 and the role of Sp1.
Biochem J
; 476(8): 1247-1266, 2019 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30914440
12.
Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection.
Bioorg Med Chem Lett
; 29(15): 1874-1880, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31176699
13.
Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.
Bioorg Med Chem
; 27(23): 115125, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31679978
14.
Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential.
Bioorg Med Chem Lett
; 28(18): 3085-3093, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30098869
15.
Structure based drug design and in vitro metabolism study: Discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent.
Bioorg Med Chem
; 26(9): 2437-2451, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29655610
16.
Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents.
Bioorg Med Chem
; 26(9): 2640-2650, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29691153
17.
Sterically induced conformational restriction: Discovery and preclinical evaluation of novel pyrrolo[3,2-d]pyrimidines as microtubule targeting agents.
Bioorg Med Chem
; 26(20): 5470-5478, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30297118
18.
Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
Bioorg Med Chem Lett
; 27(7): 1602-1607, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28258797
19.
Design, synthesis, and structure-activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells.
Bioorg Med Chem Lett
; 27(15): 3423-3430, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28610978
20.
Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.
Bioorg Med Chem
; 25(2): 545-556, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27894589