Effect of ticagrelor on acute kidney injury in septic rats and its underlying mechanism.

The aim of the present study was to determine whether the effects and underlying mechanisms of ticagrelor in a rat model of sepsis-induced acute kidney injury (AKI) were mediated via the CD62P pathway. A total of 15 rats were randomly assigned to the following groups: Normal, sham, cecal ligation and puncture (CLP), CLP + clinical dose of ticagrelor (CCD) and CLP + loading dose of ticagrelor (CLD). Ticagrelor was administered 12 h before modeling, immediately after modeling, and 12 h after modeling at a dose of 8.6 and 46.42 mg/kg in the CCD and CLD groups, respectively. Rats in the normal, sham and CLP groups were treated with the same volume of distilled water. Serum creatinine (SCr), CD62P and interleukin-1ß (IL-1ß) levels, myeloperoxidase (MPO) activity in the renal tissue and the apoptosis rate of renal cells were increased in the CLP group, compared with in the normal and sham groups (P<0.05). In addition, ticagrelor treatment reduced SCr, CD62P and IL-1ß expression levels, renal tissue MPO activity and renal cell apoptosis in rats with sepsis-induced AKI (P<0.05). CD62P expression was closely associated with the occurrence of sepsis-induced AKI. The mechanism of ticagrelor-mediated reductions in inflammation, renal neutrophil infiltration and renal cell apoptosis is possibly associated with reductions in CD62P expression.

A case report of giant hamartoma of both kidneys with spontaneous rupture and hemorrhage in a pregnant woman: A case report.

The aim of the present study was to describe a case of renal angiomyolipoma (RAML) in a 31-year-old woman who presented with massive hemorrhage, shock, severe anemia (Hb 63 g-l) and multiple lesions, prior to delivery of a dead fetus. A 31-year-old woman was admitted due to left flank and abdominal pain at 20 weeks of gestation age, and diagnosed with RAML complicated with spontaneous rupture and hemorrhage of the left kidney, for which emergency exploratory laparotomy, left kidney resection and splenectomy were performed. The patient delivered a dead fetus 3 days following surgery and recovered well postoperatively. Hemorrhagic RAML during pregnancy is a rare and complex vascular surgical emergency, and should be managed in a multidisciplinary manner. Spontaneous rupture is a serious threat to the life and health of pregnant women and fetuses. The present case is a typical example of RAML in a pregnant woman complicated by spontaneous rupture and hemorrhage, which highlights the importance of determining the risk of acute hemorrhage in early stages of pregnancy, and the significance of time and proper management. However, in cases of shock caused by spontaneous rupture and hemorrhage, the only way to save the life of the patient is to resect the lesion without delay.