Metal-free hydroalkoxylation of ynesulfonamides with esters.

An efficient metal-free hydroalkoxylation reaction of ynesulfonamides with esters under mild conditions is described. Under the catalysis of TMSOTf, various ynesulfonamides are transformed into the corresponding alkoxy-substituted enamides in high yields with complete regioselectivity and high to excellent stereoselectivity.

Metal-Free Formal Inverse-Electron-Demand Diels-Alder Reaction of 1,2-Diazines with Ynamides.

A highly effective metal-free formal inverse-electron-demand Diels-Alder reaction of 1,2-diazines with ynamides has been developed. This catalytic protocol is more environmentally friendly and allows for the construction of 2-aminonaphthalenes and 2-aminoanthracenes from 1,2-diazines and ynamides in good to high yields with wide diversity and functional group tolerance.