Imaging and histologic prognostic factors in triple-negative breast cancer and carcinoma in situ as a prognostic factor. / Valoración de los factores pronósticos radiopatológicos del cáncer de mama triple negativo y análisis del carcinoma in situ como factor pronóstico.

OBJECTIVES: To analyze what factors in magnetic resonance imaging (MRI) and histological study of triple-negative breast cancers are related to tumor recurrence and to shorter disease-free survival. To analyze survival and recurrence in function of the presence of an in situ component. MATERIAL AND METHODS: This was a retrospective study of MRI staging examinations in 122 women with triple-negative breast cancer done from 2007 through 2014. In the MRI, we evaluated morphological variables (size, margins, morphology, internal signal in T2-weighted sequences) and dynamic variables (perfusion and diffusion). In the histological study, we evaluated Ki67, p53, CK5/6, nuclear grade, and Scarff-Bloom grade, as well as the presence of an in situ component and tumor grade (high grade or not high grade). We compared the variables between patients with tumor recurrence and those without, and we conducted a survival analysis. RESULTS: Non-nodular enhancement was more common in patients with tumor recurrence (p=0.038) and was associated with shorter disease-free survival (p=0.023). Neither diffusion restriction (p=0.079) nor ki67 (p=0.052) was associated with a worse prognosis. An in situ component was detected in 44% of triple-negative tumors, and a greater proportion of patients in the group with tumor recurrence had an in situ component; however, the presence of an in situ component was not associated with shorter survival (p = 0.185). CONCLUSION: Non-nodular enhancement was associated with a worse prognosis. Diffusion restriction, ki67, and the presence of an in situ component were not associated with shorter disease-free survival.

Magnetic resonance imaging in breast cancer treated with neoadjuvant chemotherapy: radiologic-pathologic correlation of the response and disease-free survival depending on molecular subtype.

OBJECTIVES: To evaluate the radiologic and pathologic responses to neoadjuvant chemotherapy and their correlation in the molecular subtypes of breast cancer and to analyze their impact in disease-free survival. MATERIAL AND METHODS: We included 205 patients with breast cancer treated with neoadjuvant chemotherapy. We evaluated the radiologic response by comparing MRI images acquired before and after chemotherapy. The pathologic response was classified on the Miller and Payne scale. For each subtype (HER2+, TN, luminal A, luminal B HER2-, and luminal B HER2+), we used the χ(2) test, Student's t-test, ANOVA, and Kendall's Tau-b to evaluate the radiologic response and the pathologic response, the radiologic-pathologic correlation, and the disease-free survival. RESULTS: The subtypes HER2+ (62.1%) and TN (45.2%) had higher rates of complete radiologic response. The pathologic response was 65.5% in the HER2+ subtype, 38.1% in the TN subtype, 2.6% in the luminal A subtype, 8.2% in the luminal B HER2- subtype, and 31% in the luminal B HER2+ subtype. The rate of radiologic-pathologic correlation was significant in all subtypes, higher in TN and HER2 (Tau-b coefficients 0.805 and 0.717, respectively). Disease-free survival was higher in HER2+ (91.9±3.3 months) and lower in TN (69.5±6.3 months), with significant differences between the cases with poor and good radiologic responses (P=.040). Survival was greater in cases with good radiologic response, except in cases with luminal A subtype. CONCLUSION: MRI can be a useful tool that provides information about the evolution of breast cancer treated with neoadjuvant chemotherapy, which varies with the immunohistochemical subtype.

Papillary endothelial hyperplasia (Masson's tumor) of the breast: A diagnostic challenge.

Papillary endothelial hyperplasia (PEH) or Masson's tumor is a rare benign vascular tumor that usually appears in the soft tissues of the head and neck, trunk and extremities, being extremely rare in the breast. Its diagnosis can be a challenge, especially in the follow-up of patients with previous disease of breast carcinoma. We present the case of a 65-year-old patient, with a history of bilateral breast cancer and reconstruction with implants, who presented a Masson's tumor during follow-up. An ultrasound scan was performed, showing a well-circumscribed mass in the left breast, located in the posterior contour of the implant. Subsequently, magnetic resonance imaging (MR) depicted an enhancing tumor, without infiltration of adjacent structures. Finally, the definitive anatomopathological diagnosis was obtained after surgical excision.

Value of an abbreviated protocol of breast magnetic resonance imaging for screening high-risk patients. / Valor del protocolo abreviado de resonancia magnética mamaria en el cribado de pacientes de alto riesgo.

OBJECTIVE: Value the utility of breast MRI abbreviated protocols for the screening of breast cancer in high-risk patients compared to the full protocol. METHODS: We performed a retrospective review of 157 breast MRI of 82 high-risk patients practiced in our hospital between January 2011 and January 2017. Clinical, radiological and anatomopathological parameters were analyzed. Reading of the different protocols (MIP, abbreviated and full) was made by an expert radiologist. Subsequent statistical analysis was done. RESULTS: A total amount of 12 findings classified as BI-RADS 4 and 5 were identified and performed a biopsy, resulting 11 of them to be malignant (91.67%) and 1 benign (8.33%). The malignant wounds included 4 intraductal carcinoma (33.33%) and 7 infiltrating ductal carcinoma (58.33%). All injuries were detected with the three protocols and no significant differences were found between their respective area under the ROC curve (p=0.0650). CONCLUSIONS: In our study there are no significant differences between the different protocols (MIP, abbreviated and full), which places the abbreviated protocol as a promising tool for breast cancer screening in high-risk patients.

[Why is it preferable to use air in the radiological reduction of intestinal intussusception?]. / Por qué es preferible usar aire en la reducción radiológica de la invaginación intestinal?

OBJECTIVE: We present our experience describing the radiological findings in the treatment of intestinal intussusception. PATIENTS AND METHODS: A retrospective study of the clinical and ultrasound findings and their treatment in 131 intussusceptions diagnosed in 126 patients was performed. RESULTS: In 102 cases, the pneumatic intussusception reduction under radiological control was possible. Twenty-nine patients underwent surgery and amongst these the pathological changes in the intestinal wall indicated resection in 9. CONCLUSIONS: The pneumatic intussusception reduction under fluoroscopic monitoring is now more accepted than hydrostatic reduction with barium. With the proper equipment and experienced staff, this is the most promising method in the management of intestinal intussusception during infancy.

[Epidemiological study of primary brain tumors in the Autonomous Community of Aragon]. / Estudio epidemiológico de los tumores primarios cerebrales en la Comunidad Autónoma de Aragón.

OBJECTIVES: a) To analyse diverse clinical features related to the symptomatology, location and anatomopathological diagnosis of primary tumours of the C.N.S. and b) to improve knowledge of the frequency of cerebral tumours in our field of study. DESIGN: A protocolized and retrospective study of those patients diagnosed as having a primary cerebral Neoplasia. SETTING: The Autonomous Community of Aragon during the decade from 1980 to 1990. PATIENTS AND OTHER PARTICIPANTS: Our total sample consisted of 759 tumours, 412 (54.28%) in men and 347 (45.72%) in women. Our criterion for inclusion was a diagnosis of primary cerebral Neoplasia, excluding Metastasis and vascular tumours. MEASUREMENTS AND MAIN RESULTS: The majority of the cerebral tumours were located in the cerebral hemispheres (56%): migraine was the most common symptom. We confirmed that the occurrence of cerebral tumours was higher in urban than in rural zones. However the age at which these neoplastic intracranial processes present is greater in rural zones. For 67% of patients 4.5 months had to pass before it was possible to establish the diagnosis of expansive intracranial process. CONCLUSIONS: a) Migraine is the most common clinical manifestation (20%), followed by a disturbance of the higher functions (15%). b) There is considerable delay in the time needed to establish the diagnosis of expansive intracranial process, due to the present health-care framework. c) The occurrence of cerebral tumours is higher in urban than in rural zones.