RESUMO
Se estudia el comportamiento informativo de alumnos y docentes de la Facultad de Estudios Superiores Zaragoza (FESZ), de la Universidad Nacional Autónoma de México (UNAM), durante la pandemia ocasionada por el SARS-CoV-2, en la Biblioteca Digital UNAM ante el cierre total de las bibliotecas, lo que limitó la consulta presencial de libros y revistas impresas. Se llevó a cabo una investigación cuantitativa con la técnica de análisis de datos estadísticos a partir de las bitácoras de acceso a la Biblioteca Digital (BIDI UNAM) que en suma contempló 15,597 accesos, en comparación a dos periodos, antes y durante la pandemia, obteniendo como resultado un incremento en los accesos, sumado al impulso de estrategias de alfabetización informacional para el uso y aprovechamiento de los recursos de información, mismos que pueden ser integrados en los procesos de enseñanza y aprendizaje, fortaleciendo el modelo educativo de la FESZ.
The informational behavior of students and professors of the Facultad de Estudios Superiores Zaragoza (FESZ) of the Universidad Nacional Autónoma de México (UNAM) during the pandemic caused by SARS-CoV-2, is studied in the Biblioteca Digital UNAM (BIDI UNAM) before the total closure of libraries, which limited the consultation of printed books and journals. A quantitative research was carried out with the statistical data analysis technique from the access logs to the BIDI UNAM, wich in total included 15,597 accesses, compared to two periods, before and during the pandemic, obtaining as a result an increase in accesses, in addition to the promotion of information literacy strategies for the use and exploitation of information resources, which can be integrated into the teaching and learning processes, strengthening the educational model of the FESZ.
RESUMO
Epidemiological and physiological similarities among Gestational Diabetes Mellitus (GDM) and Type 2 Diabetes (T2D) suggest that both diseases, share a common genetic background. T2D risk variants have been associated to GDM susceptibility. However, the genetic architecture of GDM is not yet completely understood. We analyzed 176 SNPs for 115 loci previously associated to T2D, GDM and body mass index (BMI), as well as a set of 118 Ancestry Informative Markers (AIMs), in 750 pregnant Mexican women. Association with GDM was found for two of the most frequently replicated T2D loci: a TCF7L2 haplotype (CTTC: rs7901695, rs4506565, rs7903146, rs12243326; P=2.16 x 10(-06); OR=2.95) and a KCNQ1 haplotype (TTT: rs2237892, rs163184, rs2237897; P=1.98 x 10(-05); OR=0.55). In addition, we found two loci associated to glycemic traits: CENTD2 (60' OGTT glycemia: rs1552224, P=0.03727) and MTNR1B (HOMA B: rs1387153, P=0.05358). Remarkably, a major susceptibility SLC16A11 locus for T2D in Mexicans was not shown to play a role in GDM risk. The fact that two of the main T2D associated loci also contribute to the risk of developing GDM in Mexicans, confirm that both diseases share a common genetic background. However, lack of association with a Native American contribution T2D risk haplotype, SLC16A11, suggests that other genetic mechanisms may be in play for GDM.
Assuntos
Diabetes Mellitus Tipo 2/genética , Diabetes Gestacional/genética , Polimorfismo de Nucleotídeo Único , Adulto , Proteínas de Transporte/genética , Diabetes Mellitus Tipo 2/epidemiologia , Diabetes Gestacional/epidemiologia , Feminino , Proteínas Ativadoras de GTPase/genética , Estudos de Associação Genética , Predisposição Genética para Doença , Humanos , Canal de Potássio KCNQ1/genética , México/epidemiologia , Transportadores de Ácidos Monocarboxílicos/genética , Gravidez , Receptor MT2 de Melatonina/genética , Proteína 2 Semelhante ao Fator 7 de Transcrição/genética , Adulto JovemRESUMO
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) of the folate metabolism pathway is a candidate gene for neural tube defects (NTDs). Frequency of the second common polymorphism, A1298C, in the MTHFR gene is not well known in Mexico. Conflicting results exist regarding the association of A1298C-MTHFR with NTDs. One explanation for this controversy might be that alleles are differently distributed among various populations. The aim of the study was to determine the frequency of the A1298C-MTHFR polymorphism and its association with NTDs in a population of Yucatan, Mexico. METHODS: Genotyping was performed by use of polymerase chain reaction with restriction fragment length polymorphisms using MbOII endonuclease (PCR-RFLPs MbOII). Allele and genotype frequencies were compared between cases with NTDs, their mothers and fathers with matched controls based on an association analysis using EpiInfo software. RESULTS: A1298C genotypes were distributed according to Hardy-Weinberg expectations for all studied groups. Frequencies of allele C and heterozygous AC genotype were significantly higher in males (p = .006 and p = .011, respectively) in control group. Significant differences were not observed between cases and controls, except in mothers of NTD cases compared with mothers of healthy offspring for both allele C and heterozygous AC genotype (p = .009 and p = .01, respectively). CONCLUSIONS: The polymorphism A1298C-MTHFR is not associated with NTDs, except for mothers, suggesting only a maternal association with having NTD-affected offspring in the Yucatan population. The frequency of allele C in the control population was 10%, which is significantly lower than in other reported control populations worldwide (p < .01).