Detalhe da pesquisa
1.
Repurposing of rabeprazole as an anti-Trypanosoma cruzi drug that targets cellular triosephosphate isomerase.
J Enzyme Inhib Med Chem
; 38(1): 2231169, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37401012
2.
Human Triosephosphate Isomerase Is a Potential Target in Cancer Due to Commonly Occurring Post-Translational Modifications.
Molecules
; 28(16)2023 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37630415
3.
Improved yield, stability, and cleavage reaction of a novel tobacco etch virus protease mutant.
Appl Microbiol Biotechnol
; 106(4): 1475-1492, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-35092453
4.
The Giardial Arginine Deiminase Participates in Giardia-Host Immunomodulation in a Structure-Dependent Fashion via Toll-like Receptors.
Int J Mol Sci
; 23(19)2022 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36232855
5.
Multilevel Approach for the Treatment of Giardiasis by Targeting Arginine Deiminase.
Int J Mol Sci
; 22(17)2021 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34502400
6.
Rabeprazole inhibits several functions of Entamoeba histolytica related with its virulence.
Parasitol Res
; 119(10): 3491-3502, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32886229
7.
Differential effects on enzyme stability and kinetic parameters of mutants related to human triosephosphate isomerase deficiency.
Biochim Biophys Acta Gen Subj
; 1862(6): 1401-1409, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29571745
8.
Proton pump inhibitors drastically modify triosephosphate isomerase from Giardia lamblia at functional and structural levels, providing molecular leads in the design of new antigiardiasic drugs.
Biochim Biophys Acta
; 1860(1 Pt A): 97-107, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26518348
9.
Mutations of Glucose-6-Phosphate Dehydrogenase Durham, Santa-Maria and A+ Variants Are Associated with Loss Functional and Structural Stability of the Protein.
Int J Mol Sci
; 16(12): 28657-68, 2015 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26633385
10.
The oxidative fermentation of ethanol in Gluconacetobacter diazotrophicus is a two-step pathway catalyzed by a single enzyme: alcohol-aldehyde Dehydrogenase (ADHa).
Int J Mol Sci
; 16(1): 1293-311, 2015 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25574602
11.
The E104D mutation increases the susceptibility of human triosephosphate isomerase to proteolysis. Asymmetric cleavage of the two monomers of the homodimeric enzyme.
Biochim Biophys Acta
; 1834(12): 2702-11, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24056040
12.
Giardial triosephosphate isomerase as possible target of the cytotoxic effect of omeprazole in Giardia lamblia.
Antimicrob Agents Chemother
; 58(12): 7072-82, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25223993
13.
The stability of G6PD is affected by mutations with different clinical phenotypes.
Int J Mol Sci
; 15(11): 21179-201, 2014 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25407525
14.
Naturally occurring deamidated triosephosphate isomerase is a promising target for cell-selective therapy in cancer.
Sci Rep
; 12(1): 4028, 2022 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35256749
15.
Determining the molecular mechanism of inactivation by chemical modification of triosephosphate isomerase from the human parasite Giardia lamblia: a study for antiparasitic drug design.
Proteins
; 79(9): 2711-24, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21786322
16.
Deamidated Human Triosephosphate Isomerase is a Promising Druggable Target.
Biomolecules
; 10(7)2020 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32679775
17.
Delivery mode-associated gut microbiota in the first 3 months of life in a country with high obesity rates: A descriptive study.
Medicine (Baltimore)
; 99(40): e22442, 2020 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33019428
18.
Characterization of proteolytic activities of Giardia lamblia with the ability to cleave His-tagged N-terminal sequences.
Mol Biochem Parasitol
; 228: 16-26, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30658179
19.
On the molecular and cellular effects of omeprazole to further support its effectiveness as an antigiardial drug.
Sci Rep
; 9(1): 8922, 2019 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31222100
20.
First characterization of a microsporidial triosephosphate isomerase and the biochemical mechanisms of its inactivation to propose a new druggable target.
Sci Rep
; 8(1): 8591, 2018 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29872223