Detalhe da pesquisa
1.
An ALK2 inhibitor, BLU-782, prevents heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva.
Sci Transl Med
; 16(749): eabp8334, 2024 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38809966
2.
The discovery of benzanilides as c-Met receptor tyrosine kinase inhibitors by a directed screening approach.
Bioorg Med Chem Lett
; 21(18): 5224-9, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21835616
3.
Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations.
Biochem J
; 415(2): 197-206, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18588508
4.
The conditional kinase DeltaMEKK1:ER* selectively activates the JNK pathway and protects against serum withdrawal-induced cell death.
Cell Signal
; 17(11): 1412-22, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15893455
5.
Tumour invasion and metastasis: challenges facing drug discovery.
Curr Opin Pharmacol
; 5(4): 374-81, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15955738
6.
Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint.
Oncogene
; 21(53): 8089-104, 2002 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12444545
7.
ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest.
Oncogene
; 23(19): 3284-95, 2004 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-14981547
8.
Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.
Clin Cancer Res
; 20(22): 5745-5755, 2014 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25239608
9.
An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin.
Cancer Res
; 73(19): 6024-35, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23928993
10.
Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase.
J Med Chem
; 55(11): 5003-12, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22612866
11.
PAK1 and PAK2 have different roles in HGF-induced morphological responses.
Cell Signal
; 21(12): 1738-47, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19628037
12.
ROCK1 and LIMK2 interact in spread but not blebbing cancer cells.
PLoS One
; 3(10): e3398, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18852895