RESUMO
BACKGROUND: HLA matching in kidney transplantation is a major factor in long-term survival of the graft. In Saudi Arabia, most deceased donors are non-Saudi, making it difficult to achieve minimal HLA mismatches between donor and recipient. OBJECTIVE: To analyze HLA types of 200 deceased donors and compare them with the Saudi population's HLA types. MATERIALS AND METHODS: In a retrospective study analyzing HLA types of the last 398 deceased donors processed in a tertiary hospital in Riyadh, Saudi Arabia, HLA types of all donors were compared with HLA types from a control group of healthy Saudi persons. RESULTS: HLA types were significantly different between the deceased donor group and the Saudi population. In all deceased donors, zero mismatches was never achieved. The major differences in HLA types were in HLA-A*02, HLA-B*15, B*40, B*50, HLA-DRB1*14, DRB1*15, and DRB1*04. CONCLUSIONS: As most of our deceased donors are non-Saudis, it is difficult to match for HLA-A, HLA-B, and HLA-DR. HLA matching should be attempted nationwide by adopting different strategies, including typing donors centrally and distributing results to all centers, agreeing on a national point system for allocating organs from deceased donors, and making HLA matching a priority, especially for highly sensitized patients.
Assuntos
Antígenos HLA/sangue , Teste de Histocompatibilidade/métodos , Transplante de Rim , Obtenção de Tecidos e Órgãos/organização & administração , Humanos , Estudos Retrospectivos , Arábia SauditaRESUMO
HLA-C*04:01:01:31 differs from HLA-C*04:01:01:01 by a single nucleotide substitution (G â T) at position 72.
Assuntos
Alelos , Antígenos HLA-C/genética , Sequência de Bases , Éxons/genética , Teste de Histocompatibilidade , Humanos , Arábia SauditaRESUMO
HLA-A*30:02:01:04 differs from HLA-A*30:02:01:01 by a single nucleotide substitution (G â C) at position 3222.
Assuntos
Alelos , Antígenos HLA-A/genética , Bases de Dados Genéticas , Genoma Humano , Antígenos HLA-A/sangue , Teste de Histocompatibilidade , Humanos , Arábia SauditaRESUMO
HLA-B*18:01:01:17 differs from HLA-B*18:01:01:01 by a single nucleotide substitution (AâT) at position 3956.
Assuntos
Alelos , Antígenos HLA-B/genética , Regiões 3' não Traduzidas/genética , Genoma Humano , Teste de Histocompatibilidade , Humanos , Arábia SauditaRESUMO
HLA-DRB5*02:21 differs from HLA-DRB5*02:02 by a single-nucleotide substitution (A â G) at position 3785.
Assuntos
Alelos , Cadeias HLA-DRB5/genética , Éxons , Sequenciamento de Nucleotídeos em Larga Escala , Teste de Histocompatibilidade , Humanos , Isoleucina , Polimorfismo de Nucleotídeo Único , Arábia Saudita , ValinaRESUMO
HLA-A*23:91N differs from HLA-A*23:01:01 by a single-nucleotide substitution (G â A) at position 369.