Detalhe da pesquisa
1.
Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors.
J Biol Chem
; 298(10): 102375, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35970392
2.
Pioneering first-in-class FAAH-HDAC inhibitors as potential multitarget neuroprotective agents.
Arch Pharm (Weinheim)
; 356(12): e2300410, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37750286
3.
Development of Quinazolinone Derivatives as Modulators of Virulence Factors of Pseudomonas aeruginosa Cystic Fibrosis Strains.
Molecules
; 28(18)2023 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37764311
4.
A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors.
Int J Mol Sci
; 23(17)2022 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36077415
5.
Covalent Reversible Inhibitors of Cysteine Proteases Containing the Nitrile Warhead: Recent Advancement in the Field of Viral and Parasitic Diseases.
Molecules
; 27(8)2022 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35458759
6.
Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity.
Molecules
; 27(2)2022 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35056779
7.
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eµ-TCL1 mice through the JNK/STAT4/p66Shc axis.
Pharmacol Res
; 174: 105965, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34732370
8.
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas.
Med Res Rev
; 40(3): 1002-1060, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31742748
9.
(+)-(R)- and (-)-(S)-Perhexiline maleate: Enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages.
Bioorg Chem
; 102: 104067, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32663671
10.
Structure-Based Design of Biologically Active Compounds.
Molecules
; 25(14)2020 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32650470
11.
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II).
Bioorg Chem
; 89: 103020, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31185392
12.
A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles.
Molecules
; 24(23)2019 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31795400
13.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5.
Molecules
; 24(13)2019 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31262039
14.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.
Molecules
; 25(1)2019 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31905602
15.
Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis.
J Nat Prod
; 79(5): 1459-63, 2016 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27096224
16.
Targeting clinically-relevant metallo-ß-lactamases: from high-throughput docking to broad-spectrum inhibitors.
J Enzyme Inhib Med Chem
; 31(sup1): 98-109, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27121013
17.
Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents.
Bioorg Med Chem Lett
; 25(22): 5412-8, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26428874
18.
Rational design of the first difluorostatone-based PfSUB1 inhibitors.
Bioorg Med Chem Lett
; 24(15): 3582-6, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24909083
19.
Metalloenzyme Inhibitors against Zoonotic Infections: Focus on Leishmania and Schistosoma.
ACS Infect Dis
; 10(5): 1520-1535, 2024 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38669567
20.
Effects of structurally distinct human HDAC6 and HDAC6/HDAC8 inhibitors against S. mansoni larval and adult worm stages.
PLoS Negl Trop Dis
; 18(2): e0011992, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38416775