RESUMO
OBJECTIVE: To determine the effect of folic acid supplementation in Behçet's disease (BD) patients with ocular involvement associated with hyperhomocysteinemia (Hhcys). PATIENTS AND METHODS: 19 BD patients, all with uveitis and/or retinal vasculitis associated with Hhcys (plasma hcy > 15 micromol/l) were prospectively included. Patients were divided into 2 groups. Group 1 consisted of 11 patients that received folic acide (15 mg/d) in addition to their previous standard treatment. Group 2 included 8 patients treated only with their previous standard treatment. Visual acuity and uveitis attacks were assessed initially and monthly at each visit in all groups. Mean Visual acuity and frequency of uveitis attacks were evaluated quarterly. RESULTS: In group 1, the mean plasma hcys level was significantly lower after than before the treatment period (27.7 vs 13.1 micromol/l; p= 0.04) while it did not vary significantly in the same period in Group 2 patients. Frequency of uveitis attacks was significantly lower after than before treatment at each quarter in groupl and mean visual acuity in this group increased from 4.33 to 5.44 decimals. During the treatment period, the mean number of uveitis attacks, converted to frequency per 12 months were significantly lower in group 1 than in group 2. During this period, the VA slightly increased in group 1 and decreased in group 2 but the difference was not significant. CONCLUSION: Our results indicate that folates supplementation is useful for BD patients with Hhcys.
Assuntos
Síndrome de Behçet/tratamento farmacológico , Ácido Fólico/uso terapêutico , Hiper-Homocisteinemia/tratamento farmacológico , Complexo Vitamínico B/uso terapêutico , Adolescente , Corticosteroides/uso terapêutico , Adulto , Idoso , Ciclofosfamida/uso terapêutico , Feminino , Seguimentos , Homocisteína/sangue , Humanos , Hiper-Homocisteinemia/sangue , Imunossupressores/uso terapêutico , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Estudos Prospectivos , Vasculite Retiniana/tratamento farmacológico , Uveíte/tratamento farmacológico , Acuidade Visual/fisiologiaRESUMO
Chondroma is a benign bone tumour that usually occurs in the in carpal and phalangeal bones. The iliac involvement is very rare and should be differentiated from chondrosarcoma. The authors report a case of iliac chondroma revealed by an acetabular lytic area in a 13-year-old girl. The diagnosis of chondroma was confirmed after surgical biopsy.