Detalhe da pesquisa
1.
Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals.
J Proteome Res
; 22(10): 3159-3177, 2023 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37634194
2.
The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer.
J Biol Chem
; 297(5): 101335, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34688654
3.
Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells.
J Biol Chem
; 295(8): 2359-2374, 2020 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31896573
4.
Dasatinib Is Preferentially Active in the Activated B-Cell Subtype of Diffuse Large B-Cell Lymphoma.
J Proteome Res
; 18(1): 522-534, 2019 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30540191
5.
Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology.
J Am Chem Soc
; 141(39): 15700-15709, 2019 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31497954
6.
Kinome Profiling Identifies Druggable Targets for Novel Human Cytomegalovirus (HCMV) Antivirals.
Mol Cell Proteomics
; 16(4 suppl 1): S263-S276, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28237943
7.
Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis.
Cancer Res Commun
; 2(10): 1144-1161, 2022 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36388465
8.
Cytomegalovirus US28 regulates cellular EphA2 to maintain viral latency.
Sci Adv
; 8(43): eadd1168, 2022 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36288299
9.
Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK.
PLoS One
; 16(7): e0252048, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34264955
10.
Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition.
Cell Rep
; 35(13): 109291, 2021 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34192548
11.
Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers.
Cell Rep
; 31(11): 107764, 2020 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32553168
12.
Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues.
ACS Chem Biol
; 14(5): 1020-1029, 2019 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31021596
13.
Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer.
Sci Signal
; 12(590)2019 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31311847
14.
EPH receptor signaling as a novel therapeutic target in NF2-deficient meningioma.
Neuro Oncol
; 20(9): 1185-1196, 2018 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29982664
15.
Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth.
SLAS Discov
; 23(8): 850-861, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29742358
16.
KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism.
Cancer Cell
; 34(5): 807-822.e7, 2018 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30423298
17.
Ionizing radiation induces EphA2 S897 phosphorylation in a MEK/ERK/RSK-dependent manner.
Int J Radiat Biol
; 93(9): 929-936, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28705041
18.
BIRC6 mediates imatinib resistance independently of Mcl-1.
PLoS One
; 12(5): e0177871, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28520795
19.
Correction to "Mitochondrial Protease ClpP Is a Target for the Anticancer Compounds ONC201 and Related Analogues".
ACS Chem Biol
; 17(8): 2377-2378, 2022 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35878877